Abstract
Biology has amassed a wealth of information about the function of a multitude of protein-coding genes across species. The challenge now is to understand how all these proteins work together to form a living organism, and a crucial step for gaining this knowledge is a complete description of the molecular “wiring circuits” that underlie cellular processes. In this chapter, we describe a general computational framework for predicting multi-protein assemblies from biochemical co-fractionation data.
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Goebels, F., Hu, L., Bader, G., Emili, A. (2018). Automated Computational Inference of Multi-protein Assemblies from Biochemical Co-purification Data. In: Marsh, J. (eds) Protein Complex Assembly. Methods in Molecular Biology, vol 1764. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7759-8_25
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DOI: https://doi.org/10.1007/978-1-4939-7759-8_25
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