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Preclinical MRI pp 189–202Cite as

1H Spectroscopic Imaging of the Rodent Brain

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1718))

Abstract

Proton MR spectroscopic imaging (MRSI) can provide a variety of “molecular images” from animal models of human disease, which are useful for different research purposes. This chapter describes a protocol for in vivo acquisition and analysis of MRSI data from the rodent brain.

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Acknowledgments

This work was sponsored by grants from: La Caixa Foundation; AGAUR 2014 SGR, grant n° 928; RD12/0036/0010, integrated in Plan Nacional de I+D+I and co-funded by ISCIII-Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER) (PI14/00595); Fundació La Marató de TV3 (201441 10); and CERCA Programme/Generalitat de Catalunya. We are indebted to the Experimental MRI 7T Unit of the IDIBAPS, for the technical help.

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Authors and Affiliations

  1. Fetal i+D Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain

    Rui V. Simões

  2. Experimental 7T MRI Unit, IDIBAPS, Barcelona, Spain

    Emma Muñoz-Moreno & Guadalupe Soria

  3. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain

    Raúl Tudela & Guadalupe Soria

  4. Champalimaud Foundation, Lisbon, Portugal

    Rui V. Simões

Authors
  1. Rui V. Simões
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  2. Emma Muñoz-Moreno
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  3. Raúl Tudela
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  4. Guadalupe Soria
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Corresponding author

Correspondence to Rui V. Simões .

Editor information

Editors and Affiliations

  1. BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain

    María Luisa García Martín

  2. Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC/UAM, Madrid, Spain

    Pilar López Larrubia

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Simões, R.V., Muñoz-Moreno, E., Tudela, R., Soria, G. (2018). 1H Spectroscopic Imaging of the Rodent Brain. In: García Martín, M., López Larrubia, P. (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7531-0_12

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  • DOI: https://doi.org/10.1007/978-1-4939-7531-0_12

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7530-3

  • Online ISBN: 978-1-4939-7531-0

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