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Mouse Models of Virus-Induced Type 1 Diabetes

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Animal Models of Diabetes

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2128))

Abstract

Virus infections have been linked to the induction of autoimmunity and disease development in human type 1 diabetes. Experimental models have been instrumental in deciphering processes leading to break of immunological tolerance and type 1 diabetes development. Animal models have also been useful for proof-of-concept studies and for preclinical testing of new therapeutic interventions. This chapter describes two robust and clinically relevant mouse models for virus-induced type 1 diabetes; acceleration of disease onset in prediabetic nonobese diabetic (NOD) mice following Coxsackievirus infection and diabetes induction by lymphocytic choriomeningitis virus (LCMV) infection of transgenic mice expressing viral neo-antigens under control of the rat insulin promoter (RIP).

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Author information

Authors and Affiliations

  1. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

    Gustaf Christoffersson

  2. The Center for Infectious Medicine (CIM), Department of Medicine Huddinge, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden

    Malin Flodström-Tullberg

Authors
  1. Gustaf Christoffersson
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  2. Malin Flodström-Tullberg
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Corresponding author

Correspondence to Malin Flodström-Tullberg .

Editor information

Editors and Affiliations

  1. Department of Diabetes, School of Life Course Sciences, King’s College London, London, UK

    Aileen J. F. King

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Christoffersson, G., Flodström-Tullberg, M. (2020). Mouse Models of Virus-Induced Type 1 Diabetes. In: King, A. (eds) Animal Models of Diabetes. Methods in Molecular Biology, vol 2128. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0385-7_7

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  • DOI: https://doi.org/10.1007/978-1-0716-0385-7_7

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0384-0

  • Online ISBN: 978-1-0716-0385-7

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