Abstract
There are now a number of different mouse models for type 1 diabetes. The best known is the nonobese diabetic (NOD) mouse which has a genetic susceptibility to autoimmune diabetes with some features that are similar to human type 1 diabetes. The mice also have a propensity to other autoimmune diatheses, including autoimmune thyroid disease and sialadenitis. In addition, it is well known that environmental factors affect the incidence of disease in these mice. While there are other rodent models, including numerous transgenic and knockout models, as well as those that express human proteins, none of these develop spontaneous diabetes over a period of time, when the natural history can be studied. We focus here on the unmanipulated NOD mouse and discuss features of the husbandry and investigation of the mice that allow for use of these long-studied mice in the pathogenesis of an autoimmune type of diabetes.
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References
Kikutani H, Makino S (1992) The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51:285–322
Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980) Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 29(1):1–13
Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23:447–485. https://doi.org/10.1146/annurev.immunol.23.021704.115643
Pearson JA, Wong FS, Wen L (2016) The importance of the non obese diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun 66:76–88. https://doi.org/10.1016/j.jaut.2015.08.019
Steward CA, Gonzalez JM, Trevanion S, Sheppard D, Kerry G, Gilbert JG, Wicker LS, Rogers J, Harrow JL (2013) The non-obese diabetic mouse sequence, annotation and variation resource: an aid for investigating type 1 diabetes. Database (Oxford) 2013:bat032. https://doi.org/10.1093/database/bat032
Grattan M, Mi QS, Meagher C, Delovitch TL (2002) Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes 51(1):215–223
Pozzilli P, Signore A, Williams AJ, Beales PE (1993) NOD mouse colonies around the world – recent facts and figures. Immunol Today 14(5):193–196. https://doi.org/10.1016/0167-5699(93)90160-M
Schmid S, Koczwara K, Schwinghammer S, Lampasona V, Ziegler AG, Bonifacio E (2004) Delayed exposure to wheat and barley proteins reduces diabetes incidence in non-obese diabetic mice. Clin Immunol 111(1):108–118. https://doi.org/10.1016/j.clim.2003.09.012
Maurano F, Mazzarella G, Luongo D, Stefanile R, D'Arienzo R, Rossi M, Auricchio S, Troncone R (2005) Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat. Diabetologia 48(5):931–937. https://doi.org/10.1007/s00125-005-1718-2
Cooke A, Tonks P, Jones FM, O’Shea H, Hutchings P, Fulford AJ, Dunne DW (1999) Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice. Parasite Immunol 21(4):169–176
Zaccone P, Raine T, Sidobre S, Kronenberg M, Mastroeni P, Cooke A (2004) Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice. Eur J Immunol 34(11):3246–3256. https://doi.org/10.1002/eji.200425285
Drescher KM, Kono K, Bopegamage S, Carson SD, Tracy S (2004) Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection. Virology 329(2):381–394. https://doi.org/10.1016/j.virol.2004.06.049
Gale EA (2002) A missing link in the hygiene hypothesis? Diabetologia 45(4):588–594. https://doi.org/10.1007/s00125-002-0801-1
Wilberz S, Partke HJ, Dagnaes-Hansen F, Herberg L (1991) Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice. Diabetologia 34(1):2–5
FELASA, Mahler Convenor M, Berard M, Feinstein R, Gallagher A, Illgen-Wilcke B, Pritchett-Corning K, Raspa M (2014) FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units. Lab Anim 48(3):178–192. https://doi.org/10.1177/0023677213516312
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Chen, D., Thayer, T.C., Wen, L., Wong, F.S. (2020). Mouse Models of Autoimmune Diabetes: The Nonobese Diabetic (NOD) Mouse. In: King, A. (eds) Animal Models of Diabetes. Methods in Molecular Biology, vol 2128. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0385-7_6
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DOI: https://doi.org/10.1007/978-1-0716-0385-7_6
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