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Cell Tracking pp 141–153Cite as

Stem Cell Tracking with Nanoparticle-Based Ultrasound Contrast Agents

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2126))

Abstract

Cell therapy is revolutionizing modern medicine. To promote this emerging therapy, the ability to image and track therapeutic cells is critical to monitor the progress of the treatment. Ultrasound imaging is promising in tracking therapeutic cells but suffers from poor contrast against local tissues. Therefore, it is critical to increase the ultrasound contrast of therapeutic cells over local tissue at the injection site. Here, we describe a method to increase the ultrasound intensity of therapeutic cells with nanoparticles to make the injected therapeutic cells more visible.

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Acknowledgement

This work was supported by NIH (R00 HL117048 and DP2 HL137187) and the American Cancer Society Institutional Research (grant number 14-250-42). F. Chen also acknowledges Eric Zhao for proofreading the chapter.

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Authors and Affiliations

  1. Department of Nanoengineering, Materials Science and Engineering Program, University of California, San Diego, CA, USA

    Fang Chen & Jesse V. Jokerst

  2. Department of Ophthalmology, Stanford University, Stanford, CA, USA

    Fang Chen

  3. Department of Radiology, University of California, San Diego, CA, USA

    Jesse V. Jokerst

Authors
  1. Fang Chen
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  2. Jesse V. Jokerst
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Corresponding author

Correspondence to Fang Chen .

Editor information

Editors and Affiliations

  1. Kansas State University, Manhattan, KS, USA

    Matthew T Basel

  2. Kansas State University, Manhattan, KS, USA

    Stefan H Bossmann

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Chen, F., Jokerst, J.V. (2020). Stem Cell Tracking with Nanoparticle-Based Ultrasound Contrast Agents. In: Basel, M., Bossmann, S. (eds) Cell Tracking. Methods in Molecular Biology, vol 2126. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0364-2_13

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  • DOI: https://doi.org/10.1007/978-1-0716-0364-2_13

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0363-5

  • Online ISBN: 978-1-0716-0364-2

  • eBook Packages: Springer Protocols

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