Volume 32, Issue 7

Search all Medicinal Chemistry Research articles

July 2023

Special Issue in Honor of Dr. Nicholas A. Meanwell on the Occasion of His Retirement from Bristol Myers Squibb

Issue Editors:

John F Kadow,
T. G. Murali Dhar,
Kap-Sun Yeung

24 articles in this issue

Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell
John F. Kadow
Kap-Sun Yeung
T. G. Murali Dhar
Editorial 15 June 2023 Pages: 1205 - 1207
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
Reflections on a 40-year career in drug design and discovery
Nicholas A. Meanwell
Featured Biography 03 July 2023 Pages: 1208 - 1230
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Future challenges and opportunities with fluorine in drugs?
David O’Hagan
Robert J. Young
Comment Open access 15 June 2023 Pages: 1231 - 1234
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Toxicology Modernization: Misnomer or Momentum
Lois Lehman-McKeeman
Myrtle Davis
Comment 15 June 2023 Pages: 1235 - 1238
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Successes in antiviral drug discovery: a tribute to Nick Meanwell
David P. Rotella
Review Article 08 June 2023 Pages: 1239 - 1248
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Acyl glucuronides–mediators of drug-induced toxicities?
Thomas A. Baillie
Review Article 24 April 2023 Pages: 1249 - 1262
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes
F. Peter Guengerich
Yasuhiro Tateishi
Kevin D. McCarty
Review Article 27 May 2023 Pages: 1263 - 1277
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
Harnessing the necessary nitrogen atom in chemical biology and drug discovery
Lewis D. Pennington
Philip N. Collier
Eamon Comer
Review Article 27 May 2023 Pages: 1278 - 1293
Part of 2 collections:

Special Issue in Honor of Dr. Nicholas A. Meanwell

Drug Design reviews
The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events
Scott Hollingsworth
Scott Johnson
Veerabahu Shanmugasundaram
Review Article 19 June 2023 Pages: 1294 - 1314
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Special Issue in Honor of Dr. Nicholas A. Meanwell

Drug Design reviews
A guide for the synthesis of key nucleoside scaffolds in drug discovery
Dinithi G. Rajapaksha
Subhojit Mondal
Michael W. Meanwell
Review Article 20 June 2023 Pages: 1315 - 1333
Part of 2 collections:

Special Issue in Honor of Dr. Nicholas A. Meanwell

Drug Design reviews
Targeting MDM2 for the development of a new cancer therapy: progress and challenges
Angelo Aguilar
Junius E. Thomas
Shaomeng Wang
Review Article 23 June 2023 Pages: 1334 - 1344
Part of 2 collections:

Special Issue in Honor of Dr. Nicholas A. Meanwell

Protein-protein interactions
The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents
Nicky Hwang
Jason A. Clement
Yanming Du
Review Article 04 July 2023 Pages: 1345 - 1368
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
Carolyn D. Dzierba
Bireshwar Dasgupta
John E. Macor
Brief Report 03 June 2023 Pages: 1369 - 1375
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Synthetic studies toward a simplified eleuthoside core
Paul M. Scola
John F. Kadow
Dolatrai Vyas
Brief Report 08 July 2023 Pages: 1376 - 1382
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Special Issue in Honor of Dr. Nicholas A. Meanwell
SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole
Alice Hooper
Jonathan D. Macdonald
Shaun R. Stauffer
Brief Report 05 July 2023 Pages: 1383 - 1390
Part of 2 collections:

Special Issue in Honor of Dr. Nicholas A. Meanwell

SARS-CoV-2
Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors
Jeffrey Yang
Haifa Albanyan
Longqin Hu
Brief Report 22 April 2023 Pages: 1391 - 1399
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Novel potent and highly selective DDR1 inhibitors from integrated lead finding
Bernd Kuhn
Martin Ritter
Marco Prunotto
Original Research 15 May 2023 Pages: 1400 - 1425
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Structure-based optimization of aminothiadiazole inhibitors of AKT
Deborah S. Mortensen
Sayee G. Hegde
Rama Krishna Narla
Original Article 25 May 2023 Pages: 1426 - 1435
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Special Issue in Honor of Dr. Nicholas A. Meanwell
Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406
Simon D. P. Baugh
Anna Chaly
Richard W. Scott
Original Article 30 May 2023 Pages: 1436 - 1452
Part of 2 collections:

Special Issue in Honor of Dr. Nicholas A. Meanwell

Antifungal activity
Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis
Jacob J. Swidorski
Brett R. Beno
Alicia Regueiro-Ren
Original Article 08 June 2023 Pages: 1453 - 1480
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Special Issue in Honor of Dr. Nicholas A. Meanwell
A versatile strategy for the synthesis of various lumazine peptides
Wanli Zhang
Andrew R. Mahoney
William M. Wuest
Original Article 10 June 2023 Pages: 1481 - 1496
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env
Monisha Gupta
Gabriela Canziani
Irwin Chaiken
Original Article 27 June 2023 Pages: 1497 - 1509
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an O_lp→π*_Ar interaction
Paul M. Wehn
Song Yang
Eli M. Wallace
Original Research Article 18 July 2023 Pages: 1510 - 1531
Part of 1 collection:

Special Issue in Honor of Dr. Nicholas A. Meanwell
Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendiline and NPS R-467
Yohann J. G. Renault
Jiayin Diao
David O’Hagan
Original Research Open access 24 July 2023 Pages: 1532 - 1542
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Special Issue in Honor of Dr. Nicholas A. Meanwell

Volume 32, Issue 7

Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell

Reflections on a 40-year career in drug design and discovery

Future challenges and opportunities with fluorine in drugs?

Toxicology Modernization: Misnomer or Momentum

Successes in antiviral drug discovery: a tribute to Nick Meanwell

Acyl glucuronides–mediators of drug-induced toxicities?

C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes

Harnessing the necessary nitrogen atom in chemical biology and drug discovery

The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events

A guide for the synthesis of key nucleoside scaffolds in drug discovery

Targeting MDM2 for the development of a new cancer therapy: progress and challenges

The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

Synthetic studies toward a simplified eleuthoside core

SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors

Novel potent and highly selective DDR1 inhibitors from integrated lead finding

Structure-based optimization of aminothiadiazole inhibitors of AKT

Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406

Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis

A versatile strategy for the synthesis of various lumazine peptides

Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an O_lp→π*_Ar interaction

Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendiline and NPS R-467

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