Volume 30, Issue 7

Search all Medicinal Chemistry Research articles

July 2021

Special Issue in Honor of Professor Gary L. Grunewald for His Many Contributions and Years of Service to the Field of Medicinal Chemistry

Issue Editors:

Moorthy S. S Palanki,
Michael S Wolfe

15 articles in this issue

Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald
Moorthy S. S. Palanki
Michael S. Wolfe
Longqin Hu
Editorial 18 June 2021 Pages: 1317 - 1320
Part of 1 collection:

Special Issue in Honor of Professor Gary L. Grunewald
Targeting γ-secretase for familial Alzheimer’s disease
Michael S. Wolfe
Review Article 27 May 2021 Pages: 1321 - 1327
Part of 1 collection:

Special Issue in Honor of Professor Gary L. Grunewald
Modulators of neurolysin: promising agents for the treatment of tumor and neurological diseases
Junhui Qi
Lei Yao
Review Article 18 June 2021 Pages: 1328 - 1333
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Special Issue in Honor of Professor Gary L. Grunewald
Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
Fante Bamba
Jinshan Jin
Binghe Wang
Original Research 12 March 2021 Pages: 1334 - 1340
Part of 1 collection:

Special Issue in Honor of Professor Gary L. Grunewald
Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
Jinshan Jin
Arpana Chaudhary
Phang C. Tai
Original Research 10 June 2021 Pages: 1341 - 1347
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Special Issue in Honor of Professor Gary L. Grunewald
Sulfamate-tethered aza-Wacker approach towards analogs of Bactobolin A
Someshwar Nagamalla
David K. Johnson
Shyam Sathyamoorthi
Original Research 06 April 2021 Pages: 1348 - 1357
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Special Issue in Honor of Professor Gary L. Grunewald
Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)
Ashwini Sadanand Ranade
Joseph R. Bertino
Longqin Hu
Original Research 29 April 2021 Pages: 1358 - 1365
Part of 2 collections:

Special Issue in Honor of Professor Gary L. Grunewald

Prodrugs
Anti-TB evaluation of novel 2,3-dihydroquinazolin-4(1H)-ones and in silico studies of the active compounds
Apurba Dutta
Priyanka Trivedi
Diganta Sarma
Original Research 15 May 2021 Pages: 1366 - 1376
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Special Issue in Honor of Professor Gary L. Grunewald
Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues
Anindya Sarkar
Anushka C. Galasiti Kankanamalage
Dale L. Boger
Original Research 18 May 2021 Pages: 1377 - 1385
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Special Issue in Honor of Professor Gary L. Grunewald
Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists
Kevin J. Frankowski
Tarsis Brust
Jeffrey Aubé
Original Research 09 June 2021 Pages: 1386 - 1396
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Special Issue in Honor of Professor Gary L. Grunewald
Analogs of the κ opioid receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opioid receptor affinity, selectivity and κ opioid receptor antagonism
Wei-Jie Fang
Thomas F. Murray
Jane V. Aldrich
Original Research 17 June 2021 Pages: 1397 - 1407
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Special Issue in Honor of Professor Gary L. Grunewald
Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus
Oxana Kazakova
Liudmila Rubanik
Elmira Khusnutdinova
Original Research 17 May 2021 Pages: 1408 - 1418
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Special Issue in Honor of Professor Gary L. Grunewald
Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives
Li-Qin Qin
Zu-Zhuang Wei
Hong Liang
Original Research 22 May 2021 Pages: 1419 - 1426
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Special Issue in Honor of Professor Gary L. Grunewald
Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives
Qiu-Wan Tan
Li-Ya He
Li-Ping Guan
Original Research 24 May 2021 Pages: 1427 - 1437
Part of 1 collection:

Special Issue in Honor of Professor Gary L. Grunewald
Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting enzyme
Prima Francis
Kajal Chakraborty
Original Research 27 May 2021 Pages: 1438 - 1451
Part of 1 collection:

Special Issue in Honor of Professor Gary L. Grunewald

Volume 30, Issue 7

Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald

Targeting γ-secretase for familial Alzheimer’s disease

Modulators of neurolysin: promising agents for the treatment of tumor and neurological diseases

Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors

Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis

Sulfamate-tethered aza-Wacker approach towards analogs of Bactobolin A

Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)

Anti-TB evaluation of novel 2,3-dihydroquinazolin-4(1H)-ones and in silico studies of the active compounds

Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues

Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists

Analogs of the κ opioid receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opioid receptor affinity, selectivity and κ opioid receptor antagonism

Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus

Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives

Clathrolides A–B: previously undescribed macrocylic lactones from marine demosponge Clathria (Thalysias) vulpina (Lamarck, 1814) as potential antihypertensive leads attenuating angiotensin converting enzyme

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