1. Guest Editorial

   • Gianfabio Giorgioni, Allessandro, Richard A. Glennon

   OriginalPaper Pages: 127 - 130

2. Cardiovascular and Urinary System Receptors: Focus on Endothelin Receptor and α₁-Adrenoceptor Subtypes

   • Rodolfo Testa
   • Amedeo Leonardi

   OriginalPaper Pages: 131 - 133

3. In Vitro and In Vivo Characterization of Alpha-1A Selective Agonists and Their Utility for Stress Incontience

   • William A. Carroll
   • Robert J. Altenbach
   • James P. Sullivan

   OriginalPaper Pages: 134 - 148

4. The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist

   • David J. Rawson
   • Kevin N. Dack
   • Don Walker

   OriginalPaper Pages: 149 - 157

5. Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation

   • Herve Paris
   • Christelle Coattrieux
   • Stephane Schaak

   OriginalPaper Pages: 158 - 169

6. Pharmacophore Development and 3D-QSAR Study of I₁ Imidazoline Binding Site Ligands

   • Orazio Nicolotti
   • Angelo Carotti
   • Monique Dontenwill

   OriginalPaper 01 April 2004 Pages: 170 - 189

7. (+)-Cyclazosin Derivatives as α₁-Adrenoceptor Antagonists

   • Gianni Sagratini
   • Michela Buccioni
   • Dario Giardina

   OriginalPaper Pages: 190 - 199

8. Nuclear Receptors: Some Recent Developments

   • Henk Timmerman

   OriginalPaper Pages: 200 - 201

9. Discovery of a New Family of Membrane Progesterone Receptors in Vertebrates and Detection of the Alpha and Beta Subtypes in Mouse Brain, Testis, and Uterus

   • Peter Thomas

   OriginalPaper Pages: 202 - 209

10. Identification of Ligands for the Orphan Nuclear Receptor GCNF

    • Rogier Buijsman
    • Anja Garritsen
    • Pedro Hermkens

    OriginalPaper Pages: 210 - 215

11. Drug Discovery: Back and Forward

    • G. Gaviraghi
    • R. Pellicciari

    OriginalPaper Pages: 216 - 217

12. Analogue-Based Drug Research: Lead and Drug Optimization

    • Janos Fischer

    OriginalPaper Pages: 218 - 227

13. Regulation of Xenobiotic Detoxification by Nuclear Receptors

    • JM Pascussi
    • S Gerbal-Chaloin
    • P Maurel

    OriginalPaper Pages: 228 - 237

14. Drug Development in the 21st Century: Medicines, Man and Receptors

    • David J Triggle

    OriginalPaper Pages: 238 - 248