1. Guest Editorial

   • Gianfabio Giorgioni
   • Alessandro Piergentili
   • Richard A. Glennon

   EditorialNotes Pages: 1 - 4

2. The Evolution of Drugs

   • Hugo Kubinyi

   OriginalPaper Pages: 5 - 6

3. 25 Years Later: Latest News from the Receptors

   • Fulvio Gualtieri

   OriginalPaper Pages: 7 - 10

4. The Nicotinic Acetylcholine Receptor: 25 Years Thereafter

   • Ferdinand Hucho
   • Christoph Weise

   OriginalPaper Pages: 11 - 17

5. Monitoring Receptor Dimerisation

   • Graeme Milligan
   • Geraldine Pascal
   • Juan J. Carrillo

   OriginalPaper Pages: 18 - 24

6. Heterodimerization of G-Protein-Coupled Receptors Reveals an Unexpected Level of Pharmacological Diversity

   • Roberto Maggio
   • Marco Scarselli
   • Giovanni U. Corsini

   OriginalPaper Pages: 25 - 33

7. Modulation of Recptors and G-Proteins

   • Piero Angeli

   OriginalPaper Pages: 34 - 37

8. The Activation Mechanism of Class-III G-Protein Coupled Receptors

   • J.-P. Pin
   • J. Kniazeff
   • L. Prézeau

   OriginalPaper Pages: 38 - 51

9. Allosteric Regulation of Binding and Function at GCPRS

   • Nigel J.M. Birdsall
   • Christopher Browning
   • Sebastian Lazareno

   OriginalPaper Pages: 52 - 62

10. Polyamines May Modulate Both G Protein-Coupled Receptors and G Proteins

    • Gabriella Marucci
    • Francesca Novi
    • Carlo Melchiorre

    OriginalPaper Pages: 63 - 73

11. Nicotine and Pain

    • Richard A. Glennon

    OriginalPaper Pages: 74 - 77

12. Improgan-like Analgesics: A Family of Compounds Derived From Histamine Anatgonists

    • L.B. Hough
    • J.W. Nalwalk
    • H. Timmerman

    OriginalPaper Pages: 78 - 87

13. Potent, Selective Adenosine A1 Agonists as Potential Analgesics

    • P.J. Beswick
    • C. Bountra
    • D.J. Spalding

    OriginalPaper Pages: 88 - 98

14. Introduction to Receptors in Aging Diseases: GAB_A Receptors

    • Wolfgang Froestl

    OriginalPaper Pages: 99 - 102

15. Receptors in Aging Diseases: Dopamine Receptors

    • Gianfabio Giorgioni

    OriginalPaper Pages: 103 - 104

16. Mechanisms and Issues Relating to the Use of D1-like Dopamine Receptor Agonists for Age-related Illnesses: Parkinson’s Disease and Memory and Cognition

    • David E. Nichols
    • Mechelle M. Lewis

    OriginalPaper Pages: 105 - 114

17. Novel Mechanisms of Drug Action: Functional Selectivity at D₂ Dopamine Receptors

    • Richard B. Mailman
    • Elaine A. Gay

    OriginalPaper Pages: 115 - 126