1. The polymerase chain reaction: an improved method for the analysis of nucleic acids

   • Hans-Peter Vosberg

   Review Articles Pages: 1 - 15

2. Prenatal diagnosis of genetic disorders in preimplantation embryos: invasive and non-invasive approaches

   • Matteo Adinolfi
   • Paul E. Polani

   Review Articles Pages: 16 - 19

3. Cystic fibrosis in Finland: a molecular and genealogical study

   • Juha Kere
   • Reijo Norio
   • Albert de la Chapelle

   Original Investigations Pages: 20 - 25

4. How does inactivation change timing of replication in the human X chromosome?

   • Sabine Schwemmle
   • Karl Mehnert
   • Walther Vogel

   Original Investigations Pages: 26 - 32

5. Assignment of human desmin gene to band 2q35 by nonradioactive in situ hybridization

   • Evani Viegas-Péquignot
   • Li Zhen Lin
   • Denise Paulin

   Original Investigations Pages: 33 - 36

6. BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people

   • N. Ghanem
   • M. Bensmana
   • G. Lefranc

   Original Investigations Pages: 37 - 44

7. Fibroblast-specific common fragile sites induced by aphidicolin

   • I. Murano
   • A. Kuwano
   • T. Kajii

   Original Investigations Pages: 45 - 48

8. Partial correction of chromosome instability in Fanconi anemia by desferrioxamine

   • B. Porfirio
   • G. Ambroso
   • B. Dallapiccola

   Original Investigations Pages: 49 - 51

9. Risks of fetal cystic fibrosis based on linkage disequilibrium data

   • Susan Holloway
   • D. J. H. Brock

   Original Investigations Pages: 52 - 54

10. Autosomal dominant polycystic kidney disease and α^−4.2 thalassemia in a Caucasian family

    • Marie Claude Vinet
    • Catherine Dodé
    • Lucien Bachner

    Original Investigations Pages: 55 - 57

11. Selection of human chromosome 21-specific DNA probes for genetic analysis in Alzheimer's dementia and Down syndrome

    • Guy Van Camp
    • Piet Stinissen
    • Christine Van Broeckhoven

    Original Investigations Pages: 58 - 60

12. Assignment of anonymous DNA probes to specific intervals of human chromosomes 16 and X

    • V. J. Hyland
    • K. E. W. Fernandez
    • G. R. Sutherland

    Original Investigations Pages: 61 - 66

13. Multiple mutations underlying familial hypercholesterolemia in the South African population

    • Howard E. Henderson
    • Maritha J. Kotze
    • G. Michael B. Berger

    Original Investigations Pages: 67 - 70

14. Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites

    • Duncan J. Shaw
    • Helen G. Harley
    • Timothy W. McKeithan

    Original Investigations Pages: 71 - 74

15. A novel δ° arising from a frameshift insertion, detected by direct sequencing of enzymatically amplified DNA

    • Monique Losekoot
    • Riccardo Fodde
    • Luigi F. Bernini

    Original Investigations Pages: 75 - 78

16. Cytogenetic investigations in a family with ataxia telangiectasia

    • M. W. Humphreys
    • N. C. Nevin
    • M. A. W. Wooldridge

    Original Investigations Pages: 79 - 82

17. Detection of an unbalanced translocation (4;14) in a mildly retarded father and son by flow cytometry

    • Alexander Cooke
    • John L. Tolmie
    • J. Michael Connor

    Original Investigations Pages: 83 - 87

18. Molecular analysis of 46,XY females and regional assignment of a new Y-chromosome-specific probe

    • Michael A. Cantrell
    • James N. Bicknell
    • Christine M. Disteche

    Original Investigations Pages: 88 - 92

19. Detection of an alteration of the α₂ gene in a patient with chronic lung disease and serum α₂ deficiency

    • W. Poller
    • J. Barth
    • B. Voss

    Short Communications Pages: 93 - 96

20. Linkage analyses of human peptidase C (PEPC), human factor H (HF), and coagulation factor XIIIB (F13B)

    • J. Kömpf
    • C. Luckenbach
    • H. Ritter

    Short Communications Pages: 97 - 98

21. Erratum

    Erratum Pages: 99 - 99

22. Announcements

    Announcement Pages: 100 - 100