1. Introduction

   • Jerry Wolinsky
   • Giancarlo Comi

   OriginalPaper Pages: v1 - v2

2. The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage

   • Wolfgang Brück

   OriginalPaper Pages: v3 - v9

3. Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis

   • Wolfgang Brück

   OriginalPaper Pages: v10 - v15

4. MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system

   • Massimo Filippi
   • Maria Assunta Rocca

   OriginalPaper Pages: v16 - v24

5. Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways

   • Douglas L. Arnold

   OriginalPaper Pages: v25 - v29

6. Purely systemically active anti-inflammatory treatments are adequate to control multiple sclerosis

   • Hans-Peter Hartung
   • Bernd C. Kieseier
   • Bernhard Hemmer

   OriginalPaper Pages: v30 - v37

7. Modulating processes within the central nervous system is central to therapeutic control of multiple sclerosis

   • Tjalf Ziemssen

   OriginalPaper Pages: v38 - v45

8. Multiple sclerosis trial designs for the 21^st century: Building on recent lessons

   • Fred Lublin

   OriginalPaper Pages: v46 - v53