1. Editorial

   • Jan Hillert
   • Per Soelberg Sørensen

   OriginalPaper Pages: 1 - 2

2. A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis

   • Howard L. Weiner

   OriginalPaper Pages: 3 - 11

3. Interplay between mechanisms of damage and repair in multiple sclerosis

   • Christine Stadelmann
   • Wolfgang Brück

   OriginalPaper Pages: 12 - 18

4. The biology of CNS remyelination

   • Robin J. M. Franklin
   • Mark R. Kotter

   OriginalPaper Pages: 19 - 25

5. Glatiramer Acetate

   • François Blanchette
   • Oliver Neuhaus

   OriginalPaper Pages: 26 - 36

6. Rationale for early intervention with immunomodulatory treatments

   • Mar Tintoré

   OriginalPaper Pages: 37 - 43

7. Switching algorithms: from one immunomodulatory agent to another

   • Patricia K. Coyle

   OriginalPaper Pages: 44 - 50

8. Combination therapies in multiple sclerosis

   • Ralf Gold

   OriginalPaper Pages: 51 - 60

9. The place of conventional MRI and newly emerging MRI techniques in monitoring different aspects of treatment outcome

   • Robert Zivadinov
   • Milena Stosic
   • Michael G. Dwyer

   OriginalPaper Pages: 61 - 74

10. The search for a balance between short and long-term treatment outcomes in multiple sclerosis

    • Ulf Baumhackl

    OriginalPaper Pages: 75 - 83