1. Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review

   • Angela Elma Edwina
   • Nada Dia
   • Jos Tournoy

   Review Article 02 March 2023 Pages: 351 - 373

   

2. Alternative Methods for Therapeutic Drug Monitoring and Dose Adjustment of Tuberculosis Treatment in Clinical Settings: A Systematic Review

   • Prakruti S. Rao
   • Nisha Modi
   • Jan-Willem C. Alffenaar

   Systematic Review Open access 04 March 2023 Pages: 375 - 398

   

3. The Pharmacokinetics and Target Attainment of Antimicrobial Drugs Throughout Pregnancy: Part III Non-penicillin and Non-cephalosporin Drugs

   • F. Groen
   • J. R. Prins
   • P. Mian

   Systematic Review Open access 20 March 2023 Pages: 399 - 434

   

4. Integrated Pharmacokinetics/Pharmacodynamics Model and Simulation of the Ticagrelor Effect on Patients with Acute Coronary Syndrome

   • Zhiyan Liu
   • Yaou Liu
   • Yimin Cui

   Original Research Article 03 February 2023 Pages: 435 - 447

   

5. The Effect of BMI on Pharmacokinetic and Pharmacodynamic Parameters of Insulin Degludec: Results from an Euglycemic Glucose Clamp Study

   • Ting Li
   • Hui Liu
   • Yerong Yu

   Original Research Article 04 February 2023 Pages: 449 - 456

   

6. Can Mechanistic Static Models for Drug-Drug Interactions Support Regulatory Filing for Study Waivers and Label Recommendations?

   • Jose David Gomez-Mantilla
   • Fenglei Huang
   • Sheila Annie Peters

   Original Research Article Open access 08 February 2023 Pages: 457 - 480

   

7. Determination of the Optimal Single Dose Treatment for Acoziborole, a Novel Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Study

   • Antoine Tarral
   • Lionel Hovsepian
   • Nathalie Strub-Wourgaft

   Original Research Article Open access 10 February 2023 Pages: 481 - 491

   

8. Justifying Ribociclib Dose in Patients with Advanced Breast Cancer with Renal Impairment Based on PK, Safety, and Efficacy Data: An Innovative Approach Integrating Data from a Dedicated Renal Impairment Study and Oncology Clinical Trials

   • Yan Ji
   • Vitaly Yartsev
   • Michelle Miller

   Original Research Article Open access 17 February 2023 Pages: 493 - 504

   

9. A Model-Informed Approach to Accelerate the Clinical Development of Janagliflozin, an Innovative SGLT2 Inhibitor

   • Ling Song
   • Xiaoxu Wang
   • Dongyang Liu

   Original Research Article 18 February 2023 Pages: 505 - 518

   

10. Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling

    • Krina Mehta
    • Tingjie Guo
    • J. G. Coen van Hasselt

    Original Research Article Open access 19 February 2023 Pages: 519 - 532