1. Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations

   • Carmen Walter
   • Claudia Knothe
   • Jörn Lötsch

   Leading Article 30 December 2015 Pages: 751 - 767

2. A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development

   • Puneet Gaitonde
   • Parag Garhyan
   • Stephan Schmidt

   Review Article 21 January 2016 Pages: 769 - 788

   

3. Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics

   • Katherine L. Gill
   • Krishna K. Machavaram
   • Manoranjenni Chetty

   Review Article 27 January 2016 Pages: 789 - 805

   

4. Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome

   • Stephanie E. Reuter
   • Jennifer H. Martin

   Review Article 16 February 2016 Pages: 807 - 812

5. Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection

   • Andreas Krause
   • Jochen Zisowsky
   • Jasper Dingemanse

   Original Research Article 21 December 2015 Pages: 813 - 821

   

6. Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example

   • Sheng Feng
   • Jun Shi
   • Richard Peck

   Original Research Article Open access 29 December 2015 Pages: 823 - 832

   

7. Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

   • Anne van Rongen
   • Pyry A. J. Välitalo
   • Catherijne A. J. Knibbe

   Original Research Article Open access 27 January 2016 Pages: 833 - 847

   

8. Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations

   • Pieter Colin
   • Douglas J. Eleveld
   • Cyrill Hornuss

   Original Research Article 29 December 2015 Pages: 849 - 859

   

9. Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

   • Laura Dickinson
   • Janaki Amin
   • Rebekah Puls

   Original Research Article Open access 29 December 2015 Pages: 861 - 873

   

10. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels

    • Hannah M. Jones
    • Richard P. Butt
    • Kevin Beaumont

    Original Research Article 19 February 2016 Pages: 875 - 887

    

11. Single- and Multiple-Dose Milnacipran Pharmacokinetics in Healthy Han Chinese Volunteers

    • Can-Jun Ruan
    • An-Ning Li
    • Jose de Leon

    Short Communication 10 December 2015 Pages: 889 - 896