New drug design and development in cancer: present status and future perspectives Paul WorkmanDominique BelpommeJacques Robert Editorial Pages: 83 - 84
Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin P. CalsouB. Salles Review Pages: 85 - 89
Alkylphosphocholines: a new class of membrane-active anticancer agents P. HilgardT. KlennerC. Unger Review Pages: 90 - 95
Suramin: an anticancer drug with unique biological effects Annette Kragh Larsen Review Pages: 96 - 98
Use of pharmacokinetic-pharmacodynamic relationships in the development of new anthracyclines Jacques Robert Review Pages: 99 - 102
DNA topoisomerase I and II in cancer chemotherapy: update and perspectives Yves Pommier Review Pages: 103 - 108
Identification of serum components that inhibit the tumoricidal activity of amphiphilic alpha helical peptides Karen A. Peck-MillerRichard P. DarveauH. Perry Fell OriginalPaper Pages: 109 - 115
Non-glucocorticoid steroid analogues (21-aminosteroids) sensitize multidrug resistant cells to vinblastine Irene AbrahamCindy L. WolfKathleen E. Sampson OriginalPaper Pages: 116 - 122
The antitumor activity of the platinum complex D-17872 is associated with tumor cell differentiation Hans Rainer MaurerChristine EchartiPeter Hilgard OriginalPaper Pages: 123 - 128
L-asparaginase kills lymphoma cells by apoptosis Michael D. StoryDavid W. VoehringerRaymond E. Meyn OriginalPaper Pages: 129 - 133
Phase II study of a 72-h concurrent continuous infusion of cisplatin and etoposide in advanced non-small-cell lung cancer Hiroshi SaitoKaoru ShimokataHidehiko Saito OriginalPaper Pages: 134 - 136
Gas-chromatographic analysis of busulfan for therapeutic drug monitoring Leanne EmbreeRobbin B. BurnsJames H. Goldie OriginalPaper Pages: 137 - 142
Disposition and metabolism of KW-2149, a novel anticancer agent S. KobayashiJ. UshikiT. Hirata OriginalPaper Pages: 143 - 150
Influence of sequential exposure to R-verapamil or B8509-035 on rhodamine 123 accumulation in human lymphoblastoid cell lines Elke RollerBritta KlumppKurt Schumacher OriginalPaper Pages: 151 - 155
The comparative disposition of the pyrolloquinone GR63178A and its 9-hydroxy metabolite GR54374X in sensitive and resistant mouse colon adenocarcinoma Raymond C. FrenchJeffrey CummingsJohn F. Smyth OriginalPaper Pages: 156 - 161
Cisplatin-induced neuropathy in mature rats: Effects of the melanocortin-derived peptide ORG 2766 Frank P. T. HamersChristine PetteWillem-Hendrik Gispen OriginalPaper Pages: 162 - 166