1. ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors

   • B. Holm
   • Peter Buhl Jensen
   • Maxwell Sehested

   ORIGINAL ARTICLE Pages: 203 - 209

2. Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues

   • George E. Duran
   • Derick H. M. Lau
   • B. I. Sikic

   ORIGINAL ARTICLE Pages: 210 - 216

3. Pharmacokinetics and pharmacodynamics of the new podophyllotoxin derivative NK 611 A study by the AIO groups PHASE-I and APOH

   • K. Mross
   • A. Hüttmann
   • D. K. Hossfeld

   ORIGINAL ARTICLE Pages: 217 - 224

4. Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay

   • G. W. Aherne
   • Anthea Hardcastle
   • Lloyd R. Kelland

   ORIGINAL ARTICLE Pages: 225 - 232

5. Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs

   • Shinichi Ueno
   • Takashi Aikou
   • Toshikazu Nakamura

   ORIGINAL ARTICLE Pages: 233 - 237

6. Antitumor mechanism of action of a cyclopropyl antiestrogen (compound 7b) on human breast cancer cells in culture

   • P. T. Jain
   • J. T. Pento
   • Robert A. Magarian

   ORIGNAL ARTICLE Pages: 238 - 244

7. Nucleotide excision repair in the human ovarian carcinoma cell line (2008) and its cisplatin-resistant variant (C13*)

   • Roger A. Moorehead
   • Steven G. Armstrong
   • Gurmit Singh

   ORIGINAL ARTICLE Pages: 245 - 253

8. Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure

   • L. J. C. van Warmerdam
   • Geert-Jan Creemers
   • Jos H. Beijnen

   ORIGINAL ARTICLE Pages: 254 - 260

9. The effect of 9-β-D-arabinofuranosyl-2-fluoroadenine and 1-β-D-arabinofuranosylcytosine on the cell cycle phase distribution, topoisomerase II level, mitoxantrone cytotoxicity, and DNA strand break production in K562 human leukemia cells

   • Susan Loughlin
   • Varsha Gandhi
   • L. A. Zwelling

   ORIGINAL ARTICLE Pages: 261 - 268

10. Differentiation of HL-60 cells distinguishes between cytostatic and cytotoxic effects of the alkylphospholipid ET-18-OCH3

    • F. Civoli
    • Susan B. Pauig
    • L. W. Daniel

    ORIGINAL ARTICLE Pages: 269 - 272

11. The formation and persistence of carboplatin-DNA adducts in rats

    • Frank A. Blommaert
    • Charulla Michael
    • A. M. J. Fichtinger-Schepman

    ORIGINAL ARTICLE Pages: 273 - 280

12. Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate

    • Marie-France Pinard
    • Jacques Jolivet
    • G. Jansen

    ORIGINAL ARTICLE Pages: 281 - 288

13. A phase II study of CI-973 [SP-4-3(R)]- [1, 1-cyclobutane-dicarboxylato (2-)] (2-methyl-1,4-butanediamine-N, N′) platinum in patients with refractory advanced breast cancer

    • R. L. Theriault
    • Ronald S. Walters
    • Gabriel N. Hortobagyi

    ORIGINAL ARTICLE Pages: 289 - 291

14. Biochemical modulation of fluorouracil: comparison of methotrexate, folinic acid, and fluorouracil versus folinic acid and fluorouracil in advanced colorectal cancer: a randomized trial

    • A. Polyzos
    • N. Tsavaris
    • P. Kosmidis

    CLINICAL TRIAL REPORT Pages: 292 - 297

15. A combination of ifosfamide and mitoxantrone as salvage therapy in patients with advanced ovarian cancer

    • M. Nardi
    • Marina Della Giulia
    • F. Calabresi

    CLINICAL TRIAL REPORT Pages: 298 - 301