1. A phase I and pharmacology study of an oral platinum complex, JM216: dose-dependent pharmacokinetics with single-dose administration

   • Mark J. McKeage
   • Prakash Mistry
   • Ian R. Judson

   Original Article Pages: 451 - 458

2. Characteristic antitumor activity of cytarabine ocfosfate against human colorectal adenocarcinoma xenografts in nude mice

   • Kunihiko Koga
   • Eri Iizuka
   • Mineaki Okada

   Origical Article Pages: 459 - 462

3. Limited sampling models for simultaneous estimation of the pharmacokinetics of irinotecan and its active metabolite SN-38

   • Guy G. Chabot

   Original Article Pages: 463 - 472

4. Gender affects doxorubicin pharmacokinetics in patients with normal liver biochemistry

   • N. A. Dobbs
   • C. J. Twelves
   • R. D. Rubens

   Original Article Pages: 473 - 476

5. Serotonin metabolism following platinum-based chemotherapy combined with the serotonin type-3 antagonist tropisetron

   • Carolien P. Schröder
   • Winette T. A. van der Graaf
   • Elisabeth G. E. de Vries

   Original Article Pages: 477 - 482

6. Cellular pharmacology ofN ⁴-hexadecyl-1-β-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937

   • Daniel H. Horber
   • Herbert Schott
   • Reto A. Schwendener

   Original Article Pages: 483 - 492

7. Phase I Study of percutaneous 4-hydroxy-tamoxifen with analyses of 4-hydroxy-tamoxifen concentrations in breast cancer and normal breast tissue

   • Henri Pujol
   • Jacques Girault
   • Jean-Louis Pujol

   Original Article Pages: 493 - 498

8. The activity of deoxyspergualin in multidrug-resistant cells

   • Julie A. Holmes
   • Peter R. Twentyman

   Original Article Pages: 499 - 505

9. Etoposide protein binding in cancer patients

   • Bo Liu
   • Helena M. Earl
   • David J. Kerr

   Original Article Pages: 506 - 512

10. Phase I clinical trial of continuous infusion cyclopentenyl cytosine

    • Pedro M. Politi
    • Fuming Xie
    • Jean L. Grem

    Original Article Pages: 513 - 523

11. Interspecies differences in the kinetic properties of deoxycytidine kinase elucidate the poor utility of a phase I pharmacologically directed dose-escalation concept for 2-chloro-2′-deoxyadenosine

    • Viera Reichelová
    • Gunnar Juliusson
    • Jan Liliemark

    Original Article Pages: 524 - 529

12. Retardation of rat sciatic nerve regeneration after local application of minute doses of vincristine

    • Gé S. F. Ruigt
    • Maria H. C. den Brok

    Short Communication Pages: 530 - 535

13. ECCO 8

    Meeting Announcement Pages: 536 - 536