1. Alterations in plasma pharmacokinetics of cisplatin in tumor-bearing rats

   • Charles L. Litterst
   • Richard Magin

   Original Articles Pages: 1 - 4

2. Effect of uridine coadministration on 5′-deoxy-5-fluorouridine disposition in rats

   • J. Lai-Sim Au
   • M. Guillaume Wientjes
   • Steven L. Bramer

   Original Articles Pages: 5 - 10

3. The comparative tissues distribution of platinum and ¹⁴C in mice receiving ¹⁴C-labelled carboplatin

   • Sarah E. Dible
   • Zahid H. Siddik
   • Kenneth R. Harrap

   Original Articles Pages: 11 - 16

4. Comparison of glutathione S-transferase activity between drug-resistant and-sensitive human tumor cells: Is glutathione S-transferase associated with multidrug resistance?

   • Keisuke Yusa
   • Hirofumi Hamada
   • Takashi Tsuruo

   Original Articles Pages: 17 - 20

5. Penetration of substances into tumour tissue

   • Thore Nederman
   • Jörgen Carlsson
   • Kerstin Kuoppa

   Original Articles Pages: 21 - 25

6. Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture

   • Craig R. Fairchild
   • Jonathan Maybaum
   • James A. Straw

   Original Articles Pages: 26 - 32

7. Methotrexate administered by 6-h and 24-h infusion: a pharmacokinetic comparison

   • Joseph D. Borsi
   • Dezso Schuler
   • Peter J. Moe

   Original Articles Pages: 33 - 35

8. The growth-inhibitory effect of 4-hydroperoxycyclophosphamide against human non-small cell lung carcinoma is enhanced by low-dose difluoromethylornithine

   • Diane C. Tsai
   • Gordon D. Luk

   Original Articles Pages: 36 - 40

9. Comparison of cellular basis of drug sensitivity of human colon, pancreatic, and renal carcinoma cell lines with that of leukemia cell lines

   • Shogo Ozawa
   • Tetsuya Yasuda
   • Makoto Inaba

   Original Articles Pages: 41 - 46

10. Dose-dependent pharmacokinetics of flavone acetic acid in mice

    • Giovanna Damia
    • Maria Luisa Zanette
    • Maurizio D'Incalci

    Original Articles Pages: 47 - 50

11. Resistance and cross-resistance of the IgM immunocytoma in the LOU/M Wsl rat for cisplatin, carboplatin, and iproplatin

    • P. A. Steerenberg
    • C. P. J. Vendrik
    • J. H. Schornagel

    Original Articles Pages: 51 - 57

12. Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells

    • K. H. Link
    • K. R. Aigner
    • P. V. Danenberg

    Original Articles Pages: 58 - 62

13. Phase II trial of fludarabine phosphate (F-Ara-AMP) in patients with advanced breast cancer

    • A. Mittelman
    • R. Ashikari
    • Z. Arlin

    Original Articles Pages: 63 - 64

14. Salivary concentrations of hexamethylene bisacetamide (HMBA) in patients receiving 5-day continuous infusions

    • Barbara A. Conley
    • Merrill J. Egorin
    • Douglas E. Peterson

    Original Articles Pages: 65 - 68

15. Pharmacokinetics of Anandron in patients with advanced carcinoma of the prostate

    • Lakshmi Pendyala
    • Patrick J. Creaven
    • Christine Bertagna

    Original Articles Pages: 69 - 76

16. High activity of mitoxantrone in previously untreated low-grade lymphomas

    • Steen Werner Hansen
    • Nis I. Nissen
    • Jens Pedersen-Bjergaard

    Original Articles Pages: 77 - 79

17. In vitro chemosensitivity of brain tumors to cisplatin and its analogues, iproplatin and carboplatin

    • Pierre Dodion
    • Charlotte Sanders
    • Yvon Kenis

    Original Articles Pages: 80 - 82

18. Uridine pharmacokinetics in cancer patients

    • Thomas C. K. Chan
    • Maurie Markman
    • Stephen B. Howell

    Original Articles Pages: 83 - 86

19. Lack of effect of cisplatin on i. v. L-PAM plasma pharmacokinetics in ovarian cancer patients

    • M. Zucchetti
    • M. D'Incalci
    • C. Sessa

    Original Articles Pages: 87 - 89

20. Letter to the editors

    • Bridget T. Hill
    • Richard D. H. Whelan

    Letter to the Editors Pages: 90 - 91

21. A physiological function for multidrug-resistant membrane glycoproteins: a hypothesis regarding the renal organic cation-secretory system

    • J. Arly Nelson

    Letter to the Editors Pages: 92 - 93