Articles

1. Clinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China

   • Huan Yan
   • Lianxi Song
   • Liang Zeng

   Research Open access 07 March 2024 Article: 74

   

2. Oct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis

   • Zhuoqiong Bian
   • Xiaoling Wu
   • Yidong Wang

   Research Open access 02 March 2024 Article: 73

   

3. A phase 2 study of AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer

   • Gerald S. Falchook
   • James Reeves
   • Emerson Lim

   Research Open access 02 March 2024 Article: 72

   

4. Molecular classification reveals the sensitivity of lung adenocarcinoma to radiotherapy and immunotherapy: multi-omics clustering based on similarity network fusion

   • Jianguo Zhang
   • Yangyi Li
   • Conghua Xie

   Research Open access 02 March 2024 Article: 71

   

5. Outcomes in biomarker-selected subgroups from the KESTREL study of durvalumab and tremelimumab in recurrent or metastatic head and neck squamous cell carcinoma

   • Tanguy Y. Seiwert
   • Sophie Wildsmith
   • Amanda Psyrri

   Research Open access 02 March 2024 Article: 70

   

6. Construction of an immune predictive model and identification of TRIP6 as a prognostic marker and therapeutic target of CRC by integration of single-cell and bulk RNA-seq data

   • Wenjun Liu
   • Xitu Luo
   • Hao Liu

   Research Open access 02 March 2024 Article: 69

   

7. Size selection of intrahepatic lesions for cryoablation contributes to abscopal effect and long-term survival in patients with liver metastatic melanoma receiving PD-1 blockade therapy

   • Lujun Shen
   • Hongtong Tan
   • Weijun Fan

   Research Open access 02 March 2024 Article: 68

   

8. Neutrophils seeking new neighbors: radiotherapy affects the cellular framework and the spatial organization in a murine breast cancer model

   • C. M. Reichardt
   • M. Muñoz-Becerra
   • L. E. Muñoz

   Research Open access 02 March 2024 Article: 67

   

9. Integrating molecular subtype and CD8⁺ T cells infiltration to predict treatment response and survival in muscle-invasive bladder cancer

   • Bingyu Li
   • Kaifeng Jin
   • Weijuan Zhang

   Research Open access 02 March 2024 Article: 66

   

10. Combination of IL-33 with PD-1 blockade augment mILC2s-mediated anti-tumor immunity

    • Jiawei Yue
    • Hui Guo
    • Yumin Wu

    Research Open access 02 March 2024 Article: 65

    

11. Clinical immunotherapy in pancreatic cancer

    • Xiaorong Ye
    • Yue Yu
    • Hongdi Ma

    Review Open access 02 March 2024 Article: 64

    

12. Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases

    • Cristiana Soldani
    • Giulia De Simone
    • Laura Brunelli

    Research Open access 02 March 2024 Article: 63

    

13. Mechanism exploration of Zoledronic acid combined with PD-1 in the treatment of hepatocellular carcinoma

    • Xinru Fan
    • Zijun Yan
    • Hui Wang

    Research Open access 02 March 2024 Article: 62

    

14. Ectopic CXCR2 expression cells improve the anti-tumor efficiency of CAR-T cells and remodel the immune microenvironment of pancreatic ductal adenocarcinoma

    • Zhengjie Dai
    • Xuan Lin
    • Chen Liu

    Research Open access 02 March 2024 Article: 61

    

15. Toripalimab, a therapeutic monoclonal anti-PD-1 antibody with high binding affinity to PD-1 and enhanced potency to activate human T cells

    • Narendiran Rajasekaran
    • Xiaoguang Wang
    • Sanjay D Khare

    Research Open access 24 February 2024 Article: 60

    

16. Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer

    • Topias Karjula
    • Hanna Elomaa
    • Juha P. Väyrynen

    Research Open access 22 February 2024 Article: 59

    

17. Granzyme B+ B cells detected by single-cell sequencing are associated with prognosis in patients with intrahepatic cholangiocarcinoma following liver transplantation

    • Ji-Qiao Zhu
    • Ying Zhu
    • Qiang He

    Research Open access 22 February 2024 Article: 58

    

18. Targeting myeloperoxidase limits myeloid cell immunosuppression enhancing immune checkpoint therapy for pancreatic cancer

    • Angisha Basnet
    • Kaitlyn M. Landreth
    • Tracy W. Liu

    Research Open access 17 February 2024 Article: 57

    

19. Chemokine CCL21 determines immunotherapy response in hepatocellular carcinoma by affecting neutrophil polarization

    • Wenxin Xu
    • Jialei Weng
    • Yinghao Shen

    Research Open access 17 February 2024 Article: 56

    

20. Induction immunotherapy plus chemotherapy followed by definitive chemoradiation therapy in locally advanced esophageal squamous cell carcinoma: a propensity-score matched study

    • Hui-min Lian
    • Jia-liang Wu
    • Fang Peng

    Research Open access 16 February 2024 Article: 55

    

21. Retrospective assessment of neoadjuvant camrelizumab combined with induction chemotherapy: efficacy in laryngeal preservation for advanced hypopharyngeal and laryngeal squamous cell carcinoma

    • Jin Peng
    • Guangfeng Luo
    • Xuekui Liu

    Research Open access 15 February 2024 Article: 54

    

22. Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility

    • M. De Silva
    • B. C. Y. Tse
    • M. P. Molloy

    Review Open access 14 February 2024 Article: 53

    

23. Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy

    • Jianying Li
    • Anjun Ma
    • Gang Xin

    Research Open access 13 February 2024 Article: 52

    

24. Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade

    • Sweta Karan
    • Eunkyeong Jung
    • Nicole F. Steinmetz

    Research Open access 13 February 2024 Article: 51

    

25. Low-intensity pulsed ultrasound activated the anti-tumor immunity by irradiating the spleen of mice in 4 T-1 breast cancer

    • Yi Xia
    • Meijie Yang
    • Yan Wang

    Research Open access 13 February 2024 Article: 50

    

26. Atovaquone enhances antitumor efficacy of TCR-T therapy by augmentation of ROS-induced ferroptosis in hepatocellular carcinoma

    • Anan Chen
    • Zhiwu Yu
    • Wei Zhu

    Research Open access 13 February 2024 Article: 49

    

27. Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators

    • Yifan Ma
    • Hanmu Chen
    • Changhong Shi

    Review Open access 13 February 2024 Article: 48

    

28. Longitudinal plasma proteomic analysis identifies biomarkers and combinational targets for anti-PD1-resistant cancer patients

    • Qiaoyun Tan
    • Ruyun Gao
    • Yuankai Shi

    Research Open access 13 February 2024 Article: 47

    

29. Distinct profiles of proliferating CD8+/TCF1+ T cells and CD163+/PD-L1+ macrophages predict risk of relapse differently among treatment-naïve breast cancer subtypes

    • Konstantinos Ntostoglou
    • Sofia D. P. Theodorou
    • Christos Kittas

    Research Open access 13 February 2024 Article: 46

    

30. Treatment of secondary CNS lymphoma using CD19-targeted chimeric antigen receptor (CAR) T cells

    • Kathryn Kline
    • Tim Luetkens
    • Djordje Atanackovic

    Brief Report Open access 13 February 2024 Article: 45

    

31. INDUCE-2: A Phase I/II, open-label, two-part study of feladilimab in combination with tremelimumab in patients with advanced solid tumors

    • John F. Hilton
    • Patrick A. Ott
    • Dan P. Zandberg

    Research Open access 13 February 2024 Article: 44

    

32. Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells

    • Natthaporn Sueangoen
    • Harald Grove
    • Chanitra Thuwajit

    Research Open access 13 February 2024 Article: 43

    

33. Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment

    • Toru Hanamura
    • Kozue Yokoyama
    • Naoki Niikura

    Research Open access 13 February 2024 Article: 42

    

34. Identification macrophage signatures in prostate cancer by single-cell sequencing and machine learning

    • Zhen Kang
    • Yu-Xuan Zhao
    • Yong Wei

    Research Open access 13 February 2024 Article: 41

    

35. Enhanced T cell immune activity mediated by Drp1 promotes the efficacy of PD-1 inhibitors in treating lung cancer

    • Jietao Ma
    • Jun Song
    • Chengbo Han

    Research Open access 10 February 2024 Article: 40

    

36. Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer

    • Qin Zhu
    • Yukun Cao
    • Yu Hu

    Research Open access 31 January 2024 Article: 39

    

37. Updated systematic review and network meta-analysis of first-line treatments for metastatic renal cell carcinoma with extended follow-up data

    • Takafumi Yanagisawa
    • Keiichiro Mori
    • Takahiro Kimura

    Review Open access 30 January 2024 Article: 38

    

38. A comprehensive pan-cancer analysis of prognostic value and potential clinical implications of FTH1 in cancer immunotherapy

    • Yuejun Luo
    • Chengming Liu
    • Jie He

    Research Open access 28 January 2024 Article: 37

    

39. CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors

    • Jianghua Wang
    • Xiaoting Li
    • Baiyong Li

    Research Open access 27 January 2024 Article: 36

    

40. Unraveling T cell exhaustion in the immune microenvironment of osteosarcoma via single-cell RNA transcriptome

    • Debin Cheng
    • Zhao Zhang
    • Hongbin Fan

    Research Open access 27 January 2024 Article: 35

    

41. Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells

    • Mikel Gurrea-Rubio
    • Qi Wu
    • David A. Fox

    Research Open access 27 January 2024 Article: 34

    

42. A CAR-T response prediction model for r/r B-NHL patients based on a T cell subset nomogram

    • Xiaomei Zhang
    • Rui Sun
    • Mingfeng Zhao

    Research Open access 27 January 2024 Article: 33

    

43. The complex role of IL-10 in malignant ascites: a review

    • Yue Huang
    • Kangni Zou
    • Zhengyu Li

    Review Open access 27 January 2024 Article: 32

    

44. Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions

    • Xingchen Li
    • Wenzhi Tian
    • Jifeng Yu

    Review Open access 27 January 2024 Article: 31

45. New CEACAM-targeting 2A3 single-domain antibody-based chimeric antigen receptor T-cells produce anticancer effects in vitro and in vivo

    • Iga Jancewicz
    • Magdalena Śmiech
    • Pawel Wisniewski

    Research Open access 27 January 2024 Article: 30

    

46. Presence of Epstein–Barr virus (EBV) antigens detected by sensitive methods has no influence on local immune environment in diffuse large B cell lymphoma

    • T. Mangiaterra
    • R. Alonso-Alonso
    • P. Chabay

    Research Open access 27 January 2024 Article: 29

    

47. Tumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma

    • J. M. Versluis
    • E. P. Hoefsmit
    • C. U. Blank

    Research Open access 27 January 2024 Article: 28

    

48. Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates

    • Andrea N. Mazzarello
    • Elena Gugiatti
    • Silvia Bruno

    Research Open access 27 January 2024 Article: 27

    

49. Personalized neoantigen vaccine enhances the therapeutic efficacy of bevacizumab and anti-PD-1 antibody in advanced non-small cell lung cancer

    • Xiuhua Lin
    • Shichuan Tang
    • Baosong Xie

    Research Open access 27 January 2024 Article: 26

    

50. Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation

    • Alina D. Nikotina
    • Snezhana A. Vladimirova
    • Irina V. Guzhova

    Research Open access 27 January 2024 Article: 25