Volume 231, Issue 17

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September 2014

Neuroactive Steroids in the CNS in Memory of Robert H. Purdy'

Issue Editors:

A. Leslie Morrow,
Klaus A. Miczek,
Harriet de Wit

35 articles in this issue

Special issue in memory of Robert H. Purdy
A. Leslie Morrow
Editorial 22 April 2014 Pages: 3241 - 3242
Structure-activity relationship studies on neuroactive steroids in memory, alcohol and stress-related functions: a crucial benefit from endogenous level analysis
Monique Vallée
Review 30 April 2014 Pages: 3243 - 3255
Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
Patrizia Porcu
A. Leslie Morrow
Review 26 April 2014 Pages: 3257 - 3272
Effects of different ethanol-administration regimes on mRNA and protein levels of steroid 5α-reductase isozymes in prefrontal cortex of adolescent male rats
Pilar Sánchez
Beatriz Castro
Esperanza Ortega
Original Investigation 09 April 2014 Pages: 3273 - 3280
Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice
Antoniette M. Maldonado-Devincci
Matthew C. Beattie
A. Leslie Morrow
Original Investigation 18 April 2014 Pages: 3281 - 3292
Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ_25–35 peptide-induced toxicity in vitro and in vivo in mice
Fadia El Bitar
Johann Meunier
Yvette Akwa
Original Investigation 31 January 2014 Pages: 3293 - 3312
Progesterone in transient ischemic stroke: a dose–response study
Seema Yousuf
Fahim Atif
Donald G. Stein
Original Investigation 22 April 2014 Pages: 3313 - 3323
Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms
Dorota Zolkowska
Ashish Dhir
Michael A. Rogawski
Original Investigation 05 April 2014 Pages: 3325 - 3332
The role of ovarian hormone-derived neurosteroids on the regulation of GABA_A receptors in affective disorders
Georgina MacKenzie
Jamie Maguire
Review 09 January 2014 Pages: 3333 - 3342
The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test
Miguel Molina-Hernández
N. Patricia Téllez-Alcántara
M. Teresa Jaramillo
Original Investigation 24 August 2013 Pages: 3343 - 3350
Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats
Francesca Santoru
Roberta Berretti
Alessandra Concas
Original Investigation 13 April 2014 Pages: 3351 - 3364
Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats
C. A. Frye
C. J. Koonce
A. A. Walf
Original Investigation 17 January 2014 Pages: 3365 - 3374
Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats
C. A. Frye
C. J. Koonce
A. A. Walf
Original Investigation 01 May 2014 Pages: 3375 - 3390
Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats
Christopher D. Schmoutz
Scott P Runyon
Nicholas E. Goeders
Original Investigation 08 January 2014 Pages: 3391 - 3400
Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal
Christopher Snelling
Michelle A. Tanchuck-Nipper
Deborah A. Finn
Original Investigation 29 May 2014 Pages: 3401 - 3414
Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice
Eric W. Fish
Buddy J. Whitman
C. J. Malanga
Original Investigation 09 May 2014 Pages: 3415 - 3423
Adrenal steroid hormones and ethanol self-administration in male rhesus macaques
Christa M. Helms
Byung Park
Kathleen A. Grant
Original Investigation 01 May 2014 Pages: 3425 - 3436
Allopregnanolone modulation of HPA axis function in the adult rat
Giovanni Biggio
Maria Giuseppina Pisu
Mariangela Serra
Review 22 March 2014 Pages: 3437 - 3444
Dysregulation of vitamin D metabolism in the brain and myocardium of rats following prolonged exposure to dexamethasone
Pei Jiang
Ying Xue
Li-Hong Zhang
Original Investigation 22 January 2014 Pages: 3445 - 3451
Phosphorylation of GABA_A receptors influences receptor trafficking and neurosteroid actions
Eydith Comenencia-Ortiz
Stephen J. Moss
Paul A. Davies
Review 22 May 2014 Pages: 3453 - 3465
Modulation of the human ρ1 GABA_A receptor by inhibitory steroids
Megan M. Eaton
You Bin Lim
Gustav Akk
Review 07 December 2013 Pages: 3467 - 3478
11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABA_A receptors
Zi-Wei Chen
Cunde Wang
Alex S. Evers
Original Investigation 23 April 2014 Pages: 3479 - 3491
Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABA_A receptor function
Steven Mennerick
Amanda A. Taylor
Charles F. Zorumski
Original Investigation 20 February 2014 Pages: 3493 - 3501
Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone
Christine Ayoola
Sung Mi Hwang
Slobodan M. Todorovic
Original Investigation 07 May 2014 Pages: 3503 - 3515
Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid
Derk J. Hogenkamp
Minhtam B. Tran
Kelvin W. Gee
Original Investigation 28 February 2014 Pages: 3517 - 3524
Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABA_A receptors
Qi Hua Gong
Sheryl S. Smith
Original Investigation 17 April 2014 Pages: 3525 - 3535
Pregnenolone sulfate as a modulator of synaptic plasticity
Conor C. Smith
Terrell T. Gibbs
David H. Farb
Review 06 July 2014 Pages: 3537 - 3556
Allopregnanolone as a mediator of affective switching in reproductive mood disorders
Crystal Edler Schiller
Peter J. Schmidt
David R. Rubinow
Review 21 May 2014 Pages: 3557 - 3567
5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients
Roberto Carlos Agis-Balboa
Alessandro Guidotti
Graziano Pinna
Original Investigation 30 April 2014 Pages: 3569 - 3580
Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder
Sabra S. Inslicht
Anne Richards
Thomas C. Neylan
Original Investigation 21 June 2014 Pages: 3581 - 3595
Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol
Verica Milivojevic
Richard Feinn
Jonathan Covault
Original Investigation 17 May 2014 Pages: 3597 - 3608
Dutasteride reduces alcohol’s sedative effects in men in a human laboratory setting and reduces drinking in the natural environment
Jonathan Covault
Timothy Pond
Henry R. Kranzler
Original Investigation 21 February 2014 Pages: 3609 - 3618
Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?
Shannon K. Crowley
Susan S. Girdler
Review 23 April 2014 Pages: 3619 - 3634
Differential responses of two related neurosteroids to methylphenidate based on ADHD subtype and the presence of depressive symptomatology
Antonio Molina-Carballo
Fuensanta Justicia-Martínez
Antonio Muñoz-Hoyos
Original Investigation 06 March 2014 Pages: 3635 - 3645
Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia
Christine E. Marx
Jimmy Lee
Siow Ann Chong
Original Investigation 17 July 2014 Pages: 3647 - 3662

Volume 231, Issue 17

Special issue in memory of Robert H. Purdy

Structure-activity relationship studies on neuroactive steroids in memory, alcohol and stress-related functions: a crucial benefit from endogenous level analysis

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

Effects of different ethanol-administration regimes on mRNA and protein levels of steroid 5α-reductase isozymes in prefrontal cortex of adolescent male rats

Reduction of circulating and selective limbic brain levels of (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) following forced swim stress in C57BL/6J mice

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ_25–35 peptide-induced toxicity in vitro and in vivo in mice

Progesterone in transient ischemic stroke: a dose–response study

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

The role of ovarian hormone-derived neurosteroids on the regulation of GABA_A receptors in affective disorders

The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test

Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats

Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats

Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats

Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal

Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice

Adrenal steroid hormones and ethanol self-administration in male rhesus macaques

Allopregnanolone modulation of HPA axis function in the adult rat

Dysregulation of vitamin D metabolism in the brain and myocardium of rats following prolonged exposure to dexamethasone

Phosphorylation of GABA_A receptors influences receptor trafficking and neurosteroid actions

Modulation of the human ρ1 GABA_A receptor by inhibitory steroids

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABA_A receptors

Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABA_A receptor function

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid

Characterization of neurosteroid effects on hyperpolarizing current at α4β2δ GABA_A receptors

Pregnenolone sulfate as a modulator of synaptic plasticity

Allopregnanolone as a mediator of affective switching in reproductive mood disorders

5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients

Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder

Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol

Dutasteride reduces alcohol’s sedative effects in men in a human laboratory setting and reduces drinking in the natural environment

Neurosteroid, GABAergic and hypothalamic pituitary adrenal (HPA) axis regulation: what is the current state of knowledge in humans?

Differential responses of two related neurosteroids to methylphenidate based on ADHD subtype and the presence of depressive symptomatology

Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia

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