Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms Chris S. PridgeonConstanze SchlottChris E. P. Goldring Review Article Open access 23 January 2018 Pages: 557 - 569
Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons Mitra C. GeierAnna C. ChlebowskiRobert L. Tanguay Regulatory Toxicology 01 November 2017 Pages: 571 - 586
Predicting in vivo effect levels for repeat-dose systemic toxicity using chemical, biological, kinetic and study covariates Lisa TruongGladys OuedraogoMatthew Martin Regulatory Toxicology Open access 27 October 2017 Pages: 587 - 600
The effects of the obesogen tributyltin on the metabolism of Sertoli cells cultured ex vivo Ana M. CardosoMarco G. AlvesLuís Rato Regulatory Toxicology 09 October 2017 Pages: 601 - 610
Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods S. CasatiK. AschbergerValérie Zuang Regulatory Toxicology Open access 10 November 2017 Pages: 611 - 617
Protective effect of cadmium-induced autophagy in rat renal mesangial cells Hitomi FujishiroYing LiuDouglas M. Templeton Inorganic Compounds 07 December 2017 Pages: 619 - 631
Microscopy-based high-throughput assays enable multi-parametric analysis to assess adverse effects of nanomaterials in various cell lines Iris HansjostenJuliane RappCarsten Weiss Nanotoxicology 08 November 2017 Pages: 633 - 649
Toxicokinetic of tris(2-butoxyethyl) phosphate (TBOEP) in humans following single oral administration Wolfgang VölkelVeronika FuchsHermann Fromme Toxicokinetics and Metabolism 27 September 2017 Pages: 651 - 660
Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype Raúl A. Salazar-GonzálezEneida Turiján-EspinozaDiana P. Portales-Pérez Toxicogenomics 17 October 2017 Pages: 661 - 668
Protective effects of the resveratrol analog piceid in dopaminergic SH-SY5Y cells Sneha PotdarMayur S. ParmarJane E. Cavanaugh Molecular Toxicology 04 October 2017 Pages: 669 - 677
P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway Dandan HanJian GaoBo Han Molecular Toxicology 22 September 2017 Pages: 679 - 692
Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 β cells E. N. DoverR. BeckMiroslav Stýblo Molecular Toxicology 27 September 2017 Pages: 693 - 704
PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cells Paula PierozanOskar Karlsson Molecular Toxicology Open access 23 October 2017 Pages: 705 - 716
ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells Zhuhong ZhangZhen RenNan Mei Molecular Toxicology 09 October 2017 Pages: 717 - 728
Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17β-d-glucuronide-induced cholestasis in rats Ismael R. BarossoGisel S. MiszczukEnrique J. Sánchez Pozzi Molecular Toxicology 31 October 2017 Pages: 729 - 744
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain Evica AntonijevicJelena Kotur-StevuljevicBiljana Antonijevic Molecular Toxicology 02 November 2017 Pages: 745 - 757
t-BuOOH induces ferroptosis in human and murine cell lines Christine WenzDagmar FaustCornelia Dietrich Molecular Toxicology 03 October 2017 Pages: 759 - 775
Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-d-glucuronide in rat intestine and Caco-2 cells Guillermo Nicolás TocchettiAgostina AriasAldo Domingo Mottino Molecular Toxicology 20 October 2017 Pages: 777 - 788
Roles of cytosolic phospholipase A2α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice Nozomi FujisawaWataru YoshiokaChiharu Tohyama Molecular Toxicology Open access 17 October 2017 Pages: 789 - 801
Respiratory sensitization: toxicological point of view on the available assays Aline CharyJennifer HennenBrunhilde Blömeke Immunotoxicology 16 October 2017 Pages: 803 - 822
Effects of arsenolipids on in vitro blood-brain barrier model S. M. MüllerF. EbertT. Schwerdtle In vitro systems 20 October 2017 Pages: 823 - 832
GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS Brandon PresslyHai M. NguyenHeike Wulff Organ Toxicity and Mechanisms Open access 16 October 2017 Pages: 833 - 844
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans Dianke YuLeihong WuBaitang Ning Organ Toxicity and Mechanisms 24 October 2017 Pages: 845 - 858
Hepatotoxic combination effects of three azole fungicides in a broad dose range T. HeiseF. SchmidtP. Marx-Stoelting Organ Toxicity and Mechanisms Open access 16 October 2017 Pages: 859 - 872
Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats E. Bloch-ShildermanI. RabinovitzU. Nili Organ Toxicity and Mechanisms 10 November 2017 Pages: 873 - 892
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells Tzutzuy RamirezAlexander StrigunBen van Ravenzwaay Organ Toxicity and Mechanisms Open access 30 September 2017 Pages: 893 - 906
Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by α-naphthoflavone Eric Alejandro Rhon-CalderónCarlos Alejandro ToroAlicia Graciela Faletti Reproductive Toxicology 01 November 2017 Pages: 907 - 919
Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals? Monika WaldherrMiroslav MišíkSiegfried Knasmüller Genotoxicity and Carcinogenicity Open access 07 December 2017 Pages: 921 - 934
A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells Eleanor C. WildeKatherine E. ChapmanGareth J. S. Jenkins Genotoxicity and Carcinogenicity Open access 06 November 2017 Pages: 935 - 951
Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver Marzieh NejabatTeresa RieglerBettina Grasl-Kraupp Genotoxicity and Carcinogenicity Open access 21 December 2017 Pages: 953 - 966
Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene Alexandra S. LongJohn W. WillsPaul A. White Genotoxicity and Carcinogenicity Open access 24 November 2017 Pages: 967 - 982
Intestinal toxicity of deoxynivalenol is limited by Lactobacillus rhamnosus RC007 in pig jejunum explants Gisela Romina GarcíaDelphine PayrosIsabelle P. Oswald Biologics 09 October 2017 Pages: 983 - 993
Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A Elisabeth LimbeckJens T. VanselowAngela Mally Biologics 02 November 2017 Pages: 995 - 1014
Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary C. MahonyR. CurrieB. van de Water Guest Editorial 16 January 2018 Pages: 1015 - 1020