Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study Madalina Andreea BadeaMihaela BalasAnca Dinischiotu Nanotoxicology Open access 13 May 2024
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs Liesl K. JanssensKatleen Van UytfangheChristophe P. Stove In vitro systems 12 May 2024
Targeting gut microbiota for immunotherapy of diseases Ya-Jie YuXiao-Dong LiuYun Wang Review Article 09 May 2024
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans René GeciDomenico GadaletaStephan Schaller In silico Open access 09 May 2024
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo Julie NillesDirk TheileStephanie Ruez Toxicokinetics and Metabolism 07 May 2024
Thresholds of adversity for endocrine disrupting substances: a conceptual case study Judy ChoiStefanie RotterAndreas Hensel Regulatory Toxicology Open access 05 May 2024
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors Christopher J. BorgertLyle D. BurgoonJohn C. Matthews Molecular Toxicology Open access 05 May 2024
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome Aizhen XiongLonghui LuLi Yang Toxicogenomics and Omics Technologies 04 May 2024
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes Hanna GruszczynskaRosemary E. BarnettMark R. Viant Toxicogenomics and Omics Technologies Open access 02 May 2024
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs Merve Güdül Bacanlı Review Article Open access 30 April 2024
Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials Miriam N. JacobsSebastian HoffmannRobert Landsiedel Regulatory Toxicology Open access 30 April 2024
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study Elisabeth EckertThomas JägerThomas Göen Toxicokinetics and Metabolism Open access 26 April 2024
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility Yanping XiaoYang ShenZhengdong Zhang Genotoxicity and Carcinogenicity 25 April 2024
The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin Iman SalehRanda ZeidanMohammed Abu-Dieyeh Review Article Open access 25 April 2024
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters Abdulkarim NajjarSebastien GrégoireEstefania Cardamone In vitro systems Open access 24 April 2024
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation Chien-Ying LeeSheng-Wen WuYu-Hsiang Kuan Organ Toxicity and Mechanisms Open access 18 April 2024
Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells Yuxi LiQiangen WuSi Chen Reproductive Toxicology Open access 17 April 2024
Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells Arpamas VachiraarunwongMin GiHideki Wanibuchi Inorganic Compounds 17 April 2024
The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods Xinyi LuXin WangGuohui Sun In silico 16 April 2024
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks Jung Dae LeeJin-Sook BaeKyu-Bong Kim Organ Toxicity and Mechanisms 15 April 2024
Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties Hamza ZahidHilal TayaraKil To Chong In silico 15 April 2024
Tl(I) and Tl(III)-induce genotoxicity, reticulum stress and autophagy in PC12 Adh cells Damiana M. Salvatierra-FréchouSandra V. Verstraeten Inorganic Compounds 15 April 2024
Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults Lydia Johnson-FergusonLilly ShanahanBoris B. Quednow Organ Toxicity and Mechanisms Open access 14 April 2024
Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells Reo MatsuzakaHiroki YamaguchiTomoki Fukuyama Immunotoxicology 14 April 2024
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs Sang-Jin ParkHeeseon ParkYong-Bum Kim Immunotoxicology 12 April 2024
Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications Zhaotian FengMuhua LuanYanfei Jia Review Article 11 April 2024
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review Thiago Guedes PintoThayza Aires DiasDaniel Araki Ribeiro Review Article 10 April 2024
Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT Elisabeth VargaHélène-Christine PrauseDoris Marko Correction Open access 09 April 2024
Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2 Sara Ahmed EltayebJulia M. DresslerGiuliano Ciarimboli Molecular Toxicology Open access 08 April 2024
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing Ji-Eun SeoYuan LeXiaoqing Guo Genotoxicity and Carcinogenicity Open access 07 April 2024
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene Omayema TaoussiDiletta BerardinelliJeremy Carlier Toxicokinetics and Metabolism Open access 06 April 2024
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure Baixiu ZhengYanrong ZhengZhong Chen Review Article 06 April 2024
Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan C. KalischM. ReiterA. Mally Analytical Toxicology Open access 04 April 2024
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller’s fruit fly findings, and Muller fails to cite Snell’s findings Edward J. CalabresePaul B. Selby Letter to the Editor, News and Views 04 April 2024
The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice Yanwei WangJingru QiuHaiyan Lou Molecular Toxicology 04 April 2024
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Gerhard EisenbrandAndrea BuettnerJan G. Hengstler Editorial Open access 04 April 2024
Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish Liao-Chen ChenHwei-Hsien ChenMing-Huan Chan Organ Toxicity and Mechanisms 02 April 2024
Intestinal carcinogenicity screening of environmental pollutants using organoid-based cell transformation assay Ziwei WangShen ChenWen Chen Genotoxicity and Carcinogenicity 02 April 2024
Female offspring of mice perinatally exposed to benzophenone-3 showed early subfertility linked to a poor oocyte stockpile Valentina GallianiJulián Elías AbudHoracio Adolfo Rodríguez Reproductive Toxicology 30 March 2024
A problem formulation framework for the application of in silico toxicology methods in chemical risk assessment Jerry AcharMark T. D. CroninGunilla Öberg Regulatory Toxicology Open access 30 March 2024
Effects of the nerve agent VX on hiPSC-derived motor neurons Catherine SchaefersWolfgang SchmeißerAnnette Schmidt Organ Toxicity and Mechanisms Open access 30 March 2024
Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy Deyuan NingJinfang XueGuobing Chen Review Article 30 March 2024
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice Olamide B. AdelusiJephte Y. AkakpoHartmut Jaeschke Organ Toxicity and Mechanisms 29 March 2024
Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms Youlim SonHyun Jung LeeHwa-Young Kim Biologics 28 March 2024
Review: myogenic and muscle toxicity targets of environmental methylmercury exposure Lok Ming TamMatthew D. Rand Review Article 28 March 2024
Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk Zhenyu LiWendi ZhangMinjie Chu Toxicogenomics and Omics Technologies 27 March 2024
The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review Lei BaoQingping LiuRong Zhang Review Article 27 March 2024
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man Anja LehmannIna GeburekChristoph Hethey Toxicokinetics and Metabolism Open access 25 March 2024
Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy Xiaoqi ZhaoHao XiaoHui Wang Reproductive Toxicology 24 March 2024
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes Slobodan P. RendicF. Peter Guengerich Review Article 23 March 2024