Metabolism of alcohol ethoxylates (AEs) in rat, hamster, and human hepatocytes and liver S9: a pilot study for metabolic stability, metabolic pathway, and metabolites identification in vitro and in silico Quan ShiStefan MoorsPeter J. Boogaard Toxicokinetics and Metabolism Open access 06 June 2024
Defining the mechanisms behind the hepatoprotective properties of curcumin Farinam YashmiSajad FakhriHaroon Khan Review Article 05 June 2024
A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells Leonie T. D. WuergerHeike SprengerAlbert Braeuning Toxicogenomics and Omics Technologies Open access 04 June 2024
New insights into aflatoxin B1 mechanistic toxicology in cattle liver: an integrated approach using molecular docking and biological evaluation in CYP1A1 and CYP3A74 knockout BFH12 cell lines Silvia IoriMaija Lahtela-KakkonenMery Giantin Organ Toxicity and Mechanisms Open access 04 June 2024
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation Bernhard H. MonienNick BergauKlaus Abraham Toxicokinetics and Metabolism Open access 31 May 2024
Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium Dagmar FaustChristine WenzCornelia Dietrich Molecular Toxicology Open access 30 May 2024
A modular strategy for the testing and assessment of non-genotoxic carcinogens Kimmo LouekariMiriam N. Jacobs Regulatory Toxicology Open access 29 May 2024
Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk Chunmeng JinXiaobo TaoMinjie Chu Toxicogenomics and Omics Technologies 29 May 2024
Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment Marcel LeistAndrea BuettnerJan G. Hengstler Editorial Open access 28 May 2024
Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms Haitao YangShuyan NiuYuying Xue Review Article 28 May 2024
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity Paul A. FitzpatrickJulia JohanssonJorrit J. Hornberg In vitro systems Open access 28 May 2024
Patulin alters alpha-adrenergic receptor signalling and induces epigenetic modifications in the kidneys of C57BL/6 mice Makabongwe MazibukoTerisha GhaziAnil Chuturgoon Molecular Toxicology Open access 28 May 2024
Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review Luka KazenskyKatarina MatkovićGoran Gajski Review Article 28 May 2024
The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods Isisdoris Rodrigues de SouzaMartina IuliniEmanuela Corsini Immunotoxicology Open access 28 May 2024
The Emerging Role of Natural Products in Cancer Treatment Sumit GhoshSanjib Kumar DasParames C. Sil Review Article 25 May 2024
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions Ruiyang MengXingde DuHuizhen Zhang Review Article 25 May 2024
In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods Runze LiuJiří NovákKlára Hilscherová In vitro Systems Open access 25 May 2024
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents Eliska PrchalovaRudolf AndrysDavid Malinak Molecular Toxicology 24 May 2024
Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Gerhard EisenbrandAndrea BuettnerJan G. Hengstler Correction Open access 23 May 2024
Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice Dakota R. RobartsDiego Paine-CabreraUdayan Apte Organ Toxicity and Mechanisms 23 May 2024
Glutathione conjugation of sesquimustard: in vitro investigation of potential biomarkers Muharrem CenkHavva Bekiroğlu AtaşSuna Sabuncuoğlu Analytical Toxicology Open access 23 May 2024
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations Radwa AlmamounPaula PierozanOskar Karlsson Reproductive Toxicology Open access 20 May 2024
Neurotoxicity of crack cocaine exposure: evidence from a systematic review of in vitro and in vivo studies Raphael Caio Tamborelli GarciaLidia Emmanuela Wiazowski SpeltaTania Marcourakis Review Article 20 May 2024
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4 Fabian WagenaarsPeter CenijnTimo Hamers In vitro systems Open access 18 May 2024
A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats Min GiShugo SuzukiHideki Wanibuchi Genotoxicity and Carcinogenicity 18 May 2024
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis Anatoly V. SkalnyMichael AschnerAlexey A. Tinkov Review Article 17 May 2024
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling Véronique M. P. de BruijnIvonne M. C. M. Rietjens Organ Toxicity and Mechanisms Open access 17 May 2024
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition Valentina FogalFilippos MichopoulosMuireann Coen Toxicogenomics and Omics Technologies Open access 17 May 2024
Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics Rui WangWei LangLi Guo Genotoxicity and Carcinogenicity 17 May 2024
Associations among global long interspersed nuclear element-1 DNA methylation, metal exposure, and chronic kidney disease Yu-Mei HsuehMei-Chieh ChenYa-Li Huang Organ Toxicity and Mechanisms 16 May 2024
Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture medium Shinichiro HoriuchiYukie KurodaSeiichi Ishida In vitro systems Open access 16 May 2024
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells Patrícia AlvesCristina AmaralGeorgina Correia-da-Silva Molecular Toxicology Open access 15 May 2024
The role of cellular senescence in neurodegenerative diseases Yating WangKamil KucaKlaudia Jomova Review Article Open access 15 May 2024
The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns Brian A. Baldo Review Article 14 May 2024
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures Milos MihajlovicSybren De BoeverMathieu Vinken Organ Toxicity and Mechanisms Open access 14 May 2024
Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study Madalina Andreea BadeaMihaela BalasAnca Dinischiotu Nanotoxicology Open access 13 May 2024
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs Liesl K. JanssensKatleen Van UytfangheChristophe P. Stove In vitro systems 12 May 2024
Targeting gut microbiota for immunotherapy of diseases Ya-Jie YuXiao-Dong LiuYun Wang Review Article 09 May 2024
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans René GeciDomenico GadaletaStephan Schaller In silico Open access 09 May 2024
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo Julie NillesDirk TheileStephanie Ruez Toxicokinetics and Metabolism 07 May 2024
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors Christopher J. BorgertLyle D. BurgoonJohn C. Matthews Molecular Toxicology Open access 05 May 2024 Pages: 1795 - 1807
Thresholds of adversity for endocrine disrupting substances: a conceptual case study Judy ChoiStefanie RotterAndreas Hensel Regulatory Toxicology Open access 05 May 2024
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome Aizhen XiongLonghui LuLi Yang Toxicogenomics and Omics Technologies 04 May 2024
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes Hanna GruszczynskaRosemary E. BarnettMark R. Viant Toxicogenomics and Omics Technologies Open access 02 May 2024
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs Merve Güdül Bacanlı Review Article Open access 30 April 2024 Pages: 1717 - 1725
Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials Miriam N. JacobsSebastian HoffmannRobert Landsiedel Regulatory Toxicology Open access 30 April 2024
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study Elisabeth EckertThomas JägerThomas Göen Toxicokinetics and Metabolism Open access 26 April 2024 Pages: 1771 - 1780
The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin Iman SalehRanda ZeidanMohammed Abu-Dieyeh Review Article Open access 25 April 2024 Pages: 1659 - 1683
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility Yanping XiaoYang ShenZhengdong Zhang Genotoxicity and Carcinogenicity 25 April 2024
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters Abdulkarim NajjarSebastien GrégoireEstefania Cardamone In vitro systems Open access 24 April 2024