1. Impact of toxicological regulations on modern society Preface

   • G. Zbinden

   EditorialNotes Pages: 1 - 1

2. The no-effect level, an old bone of contention in toxicology

   • Gerhard Zbinden

   OriginalPaper Pages: 3 - 7

3. Constraints of drug regulation on the development of new drugs

   • F. Gross

   OriginalPaper Pages: 9 - 17

4. Governmental toxicology regulations: an encumbrance to drug research?

   • J. Gelzer

   OriginalPaper Pages: 19 - 26

5. Toxicological barriers to providing better drugs

   • Louis Lasagna

   OriginalPaper Pages: 27 - 33

6. United States governmental efforts to improve the regulation of toxic substances

   • Robert L. Dixon

   OriginalPaper Pages: 35 - 45

7. The acute toxic effects of hexachloro-1 : 3-butadiene on the rat kidney

   • Edward A. Lock
   • John Ishmael

   Original Investigations Pages: 47 - 57

8. A role of red cell pyrimidine 5′-nucleotidase in experimental lead poisoning

   • Hisaichi Fujii

   Original Investigations Pages: 59 - 64

9. Endosulfan poisoning and chronic brain syndrome

   • Dov R. Aleksandrowicz

   Original Investigations Pages: 65 - 68

10. Eine tödlich verlaufene Monointoxikation mit Flurazepam (Dalmadorm^®)

    • R. Aderjan
    • R. Mattern

    Original Investigations Pages: 69 - 75

11. Trithion-levels in a fatal case

    • A. Coutselinis
    • L. Poulos
    • S. Qammaz

    Short Communication Pages: 77 - 79

12. The effects of direct renal exposure to metallic cadmium

    • S. R. Greenberg

    Letter to the Editor Pages: 81 - 82

13. Formation of pre-neoplastic hepatocellular foci by vinyl bromide in newborn rats

    • Hermann M. Bolt
    • Reinhold J. Laib
    • Gerhard Stöckle

    Letter to the Editor Pages: 83 - 84