1. 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome

   • Mei ElGindi
   • Jiranuwat Sapudom
   • Jeremy Teo

   Original Article 05 September 2022 Article: 508

   

2. miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex

   • Yanli Zhang
   • Yingting Pang
   • Ming Xiao

   Original Article 04 September 2022 Article: 507

   

3. Zebrafish: an important model for understanding scoliosis

   • Haibo Xie
   • Mingzhu Li
   • Chengtian Zhao

   Review 04 September 2022 Article: 506

   

4. Small leucine zipper protein functions as a modulator for metabolic reprogramming of colorectal cancer cells by inducing nutrient stress-mediated autophagy

   • Suhyun Kim
   • Minseok Oh
   • Jesang Ko

   Original Article 04 September 2022 Article: 505

   

5. Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer

   • Miguel A. Zaballos
   • Adrián Acuña-Ruiz
   • Pilar Santisteban

   Original Article Open access 03 September 2022 Article: 504

   

6. Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

   • Iwona Maria Pranke
   • Benoit Chevalier
   • Aleksander Edelman

   Original Article 01 September 2022 Article: 503

   

7. Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades

   • Mohamed Noureldein
   • Rashad Nawfal
   • Assaad A. Eid

   OriginalPaper 30 August 2022 Article: 502

   

8. The contribution of proteasomal impairment to autophagy activation by C9orf72 poly-GA aggregates

   • Mei Pu
   • Yusi Tai
   • Jin Ren

   Original Article 29 August 2022 Article: 501

   

9. Misfolded protein oligomers induce an increase of intracellular Ca²⁺ causing an escalation of reactive oxidative species

   • Giulia Fani
   • Chiara Ester La Torre
   • Fabrizio Chiti

   Original Article Open access 27 August 2022 Article: 500

   

10. Functional diversity of apolipoprotein E: from subcellular localization to mitochondrial function

    • Johanna Rueter
    • Gerald Rimbach
    • Patricia Huebbe

    Review Open access 26 August 2022 Article: 499

    

11. Sertoli cell survival and barrier function are regulated by miR-181c/d-Pafah1b1 axis during mammalian spermatogenesis

    • Yue Feng
    • Dake Chen
    • Fenge Li

    Original Article Open access 25 August 2022 Article: 498

    

12. The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA)

    • Nora Tula Detering
    • Tobias Schüning
    • Peter Claus

    Review 25 August 2022 Article: 497

    

13. Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex

    • Jorge Ramirez-Franco
    • Fodil Azzaz
    • Oussama El Far

    Original Article 25 August 2022 Article: 496

    

14. Cdk5 regulates IP3R1-mediated Ca²⁺ dynamics and Ca²⁺-mediated cell proliferation

    • Saranya NavaneethaKrishnan
    • Vincent Law
    • Ki-Young Lee

    Original Article Open access 24 August 2022 Article: 495

    

15. Aging impairs arterial compliance via Klotho-mediated downregulation of B-cell population and IgG levels

    • Jun Fan
    • Shirley Wang
    • Zhongjie Sun

    Original Article 24 August 2022 Article: 494

    

16. Convergent evolutionary counterion displacement of bilaterian opsins in ciliary cells

    • Kazumi Sakai
    • Hiroki Ikeuchi
    • Takahiro Yamashita

    Original Article 24 August 2022 Article: 493

    

17. Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system

    • Lee E. Eiden
    • Vito S. Hernández
    • Limei Zhang

    Review 23 August 2022 Article: 492

    

18. Environmental and intrinsic modulations of venous differentiation

    • Laurence Pibouin-Fragner
    • Anne Eichmann
    • Luc Pardanaud

    Original Article 20 August 2022 Article: 491

    

19. Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs

    • Azman Embarc-Buh
    • Rosario Francisco-Velilla
    • Encarnacion Martinez-Salas

    Original Article Open access 20 August 2022 Article: 490

    

20. Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process

    • Antero Salminen

    Review Open access 20 August 2022 Article: 489

    

21. Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis

    • Yunhui Zhang
    • Wenjie Liu
    • Peng Wang

    Original Article Open access 19 August 2022 Article: 488

    

22. WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose

    • Cristina Carvalho
    • Sónia C. Correia
    • Paula I. Moreira

    Original Article 19 August 2022 Article: 487

    

23. New insights into the bile acid-based regulatory mechanisms and therapeutic perspectives in alcohol-related liver disease

    • Yali Liu
    • Tao Liu
    • Yanhang Gao

    Review 17 August 2022 Article: 486

    

24. Effect of chronic stress on tumorigenesis and development

    • Chen Wang
    • Yumeng Shen
    • Yong Yang

    Review 16 August 2022 Article: 485

    

25. A context-dependent and disordered ubiquitin-binding motif

    • Jesper E. Dreier
    • Andreas Prestel
    • Birthe B. Kragelund

    Original Article Open access 16 August 2022 Article: 484

    

26. Excess intracellular ATP causes neuropathic pain following spinal cord injury

    • Nobuhiko Nakajima
    • Yuichiro Ohnishi
    • Haruhiko Kishima

    Original Article 16 August 2022 Article: 483

    

27. Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance

    • Qijing Li
    • Jianghong Zhong
    • Rikard Holmdahl

    Original Article Open access 14 August 2022 Article: 482

    

28. mRNA m⁵C inhibits adipogenesis and promotes myogenesis by respectively facilitating YBX2 and SMO mRNA export in ALYREF-m⁵C manner

    • Youhua Liu
    • Ying Yang
    • Xinxia Wang

    Original Article 12 August 2022 Article: 481

    

29. Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target

    • Douglas Arneson
    • Guanglin Zhang
    • Xia Yang

    Original Article Open access 11 August 2022 Article: 480

    

30. Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells

    • Lisa Epping
    • Christina B. Schroeter
    • Sven G. Meuth

    Original Article Open access 11 August 2022 Article: 479

    

31. Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis

    • Anwar Shabna
    • Jayesh Antony
    • Ruby John Anto

    Original Article 10 August 2022 Article: 478

    

32. Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells

    • Nicole Koller
    • Philipp Höllthaler
    • Robert Tampé

    Original Article Open access 10 August 2022 Article: 477

    

33. Thyroid hormone signaling in the intestinal stem cells and their niche

    • Maria Virginia Giolito
    • Michelina Plateroti

    Review 10 August 2022 Article: 476

    

34. A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells

    • Lisa Linck-Paulus
    • Tina Meißgeier
    • Anja K. Bosserhoff

    Original Article Open access 09 August 2022 Article: 475

    

35. Emerging role of tumor suppressor p53 in acute and chronic kidney diseases

    • Jessica M. Overstreet
    • Cody C. Gifford
    • Rohan Samarakoon

    Review 09 August 2022 Article: 474

    

36. Mechanisms involved in hematopoietic stem cell aging

    • Takeshi Fujino
    • Shuhei Asada
    • Toshio Kitamura

    Review 08 August 2022 Article: 473

    

37. Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma

    • Mankun Wei
    • Uli Nurjanah
    • Vivi Kasim

    Original Article 06 August 2022 Article: 472

    

38. Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy

    • Vilmos Tóth
    • Henrietta Vadászi
    • József Kardos

    Original Article Open access 06 August 2022 Article: 471

    

39. Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights

    • Bowen Li
    • Bo Yang
    • Wei Chen

    Review 06 August 2022 Article: 470

    

40. BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner

    • Zengli Liu
    • Chunxiao Hu
    • Yunfei Xu

    Original Article 06 August 2022 Article: 469