1. Contribution of biopharmaceutics and pharmacokinetics to improve drug therapy

   • A. Domínguez-Gil

   OriginalPaper Pages: 1 - 5

2. Perspectives of in vitro dissolution tests in establishing in vivo/in vitro correlations

   • M. Siewert

   OriginalPaper Pages: 7 - 18

3. Pharmacokinetic studies in healthy volunteers in the context of in vitro/in vivo correlations

   • B. Oosterhuis
   • J. H. G. Jonkman

   OriginalPaper Pages: 19 - 30

4. Integration of animal pharmacokinetic and pharmacodynamic data in drug safety assessment

   • D. A. Smith

   OriginalPaper Pages: 31 - 39

5. Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives

   • M. Danhof
   • J. W. Mandema
   • R. A. A. Mathôt

   OriginalPaper Pages: 41 - 47

6. Pharmacokinetic-pharmacodynamic relationships in Phase I/Phase II of drug development

   • A. Van Peer
   • E. Snoeck
   • J. Heykants

   OriginalPaper Pages: 49 - 59

7. Pharmacokinetic and pharmacodynamic data and models in clinical trials

   • J. L. Steimer
   • M. E. Ebelin
   • J. Van Bree

   OriginalPaper Pages: 61 - 76

8. Pharmacokinetics of endogenous substances: Some problems and some solutions

   • A. Marzo
   • A. Rescigno

   OriginalPaper Pages: 77 - 88

9. Microdialysis in pharmacokinetics

   • L. Ståhle

   OriginalPaper Pages: 89 - 96

10. Sparse data analysis

    • L. Aarons

    OriginalPaper Pages: 97 - 100

11. Identification of populations at risk in drug testing and therapy: Application to elderly patients

    • W. A. Ritschel

    OriginalPaper Pages: 101 - 111

12. In vitro/in vivo correlations: Scientific implications and standardisation

    • J. M. Cardot
    • E. Beyssac

    OriginalPaper Pages: 113 - 120

13. In vitro/in vivo correlations in biopharmaceutics: scientific and regulatory implications

    • J. P. Skelly
    • G. F. Shiu

    OriginalPaper Pages: 121 - 129