1. Introduction

   • Rüdiger Landgraf

   EditorialNotes Pages: S1 - S2

2. Transcription of the insulin gene: towards defining the glucosesensitive cis-element and trans-acting factors

   • D. Melloul
   • E. Cerasi

   OriginalPaper Pages: S3 - S10

3. Glucose induces oscillatory Ca²⁺ signalling and insulin release in human pancreatic beta cells

   • B. Hellman
   • E. Gylfe
   • Z. Ling

   OriginalPaper Pages: S11 - S20

4. Protein phosphorylation and beta-cell function

   • S. J. H. Ashcroft

   OriginalPaper Pages: S21 - S29

5. Regulation of insulin secretion: the role of second messengers

   • S. L. Howell
   • P. M. Jones
   • S. J. Persaud

   OriginalPaper Pages: S30 - S35

6. The beta cell in NIDDM: giving light to the blind

   • W. J. Malaisse

   OriginalPaper Pages: S36 - S42

7. Short-term regulation of glucokinase

   • E. Van Schaftingen

   OriginalPaper Pages: S43 - S47

8. Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases

   • J. C. Hutton

   OriginalPaper Pages: S48 - S56

9. Physiologic relevance of heterogeneity in the pancreatic beta-cell population

   • D. Pipeleers
   • R. Kiekens
   • F. Schuit

   OriginalPaper Pages: S57 - S64

10. Proinsulin processing in the regulated and the constitutive secretory pathway

    • P. A. Halban

    OriginalPaper Pages: S65 - S72

11. Molecular biology of IDDM

    • Å. Lernmark

    OriginalPaper Pages: S73 - S81

12. On the pathogenesis of IDDM

    • J. Nerup
    • T. Mandrap-Poulsen
    • T. Lorenzen

    OriginalPaper Pages: S82 - S89

13. IDDM: an islet or an immune disease?

    • C. Boitard
    • E. Larger
    • J. F. Bach

    OriginalPaper Pages: S90 - S98

14. Does C-peptide have a physiological role?

    • J. Wahren
    • B. -L. Johansson
    • H. Wallberg-Henriksson

    OriginalPaper Pages: S99 - S107

15. Implantable insulin pumps and metabolic control

    • K. D. Hepp

    OriginalPaper Pages: S108 - S111

16. Functional aspects of mouse islets transplanted to the kidney

    • I. -B. Täljedal
    • C. L. Shi
    • P. Rooth

    OriginalPaper Pages: S112 - S116

17. Insulin receptor internalization: molecular mechanisms and physiopathological implications

    • J. -L. Carpentier

    OriginalPaper Pages: S117 - S124

18. Signalling through the insulin receptor and the insulin-like growth factor-I receptor

    • E. Van Obberghen

    OriginalPaper Pages: S125 - S134

19. The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

    • P. De Meyts

    OriginalPaper Pages: S135 - S148

20. Modulation of insulin receptor signalling: significance of altered receptor isoform patterns and mechanism of hyperglycaemia-induced receptor modulation

    • H. U. Häring
    • M. Kellerer
    • L. Mosthaf

    OriginalPaper Pages: S149 - S154

21. Mechanisms modifying glucose oxidation in diabetes mellitus

    • P. J. Randle
    • D. A. Priestman
    • A. Halsall

    OriginalPaper Pages: S155 - S161

22. The pathogenesis of NIDDM

    • C. N. Hales

    OriginalPaper Pages: S162 - S168

23. Central nervous system and peripheral abnormalities: clues to the understanding of obesity and NIDDM

    • B. Jeanrenaud

    OriginalPaper Pages: S169 - S178

24. Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus

    • E. R. Froesch
    • M. Hussain

    OriginalPaper Pages: S179 - S185

25. Summary

    • P. F. Freychet

    Abstract Pages: S186 - S187