1. Glycemic Variability, Glycated Hemoglobin, and Cardiovascular Complications: Still a Dilemma in Clinical Practice

   • Antonio Ceriello
   • Ali A. Rizvi
   • Manfredi Rizzo

   Editorial 10 November 2021 Pages: 1 - 4

2. Emerging Treatment Modalities for Neovascular Age-Related Macular Degeneration: A Systematic Overview

   • Dionysis D. Balatsoukas
   • Konstantinos T. Tsaousis
   • Fotis Topouzis

   Review 01 November 2021 Pages: 5 - 32

   

3. A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives

   • Marc Evans
   • Ruth D. Lewis
   • W. David Strain

   Review Open access 05 November 2021 Pages: 33 - 43

   

4. A Review of the Totality of Evidence for the Development and Approval of ABP 710 (AVSOLA), an Infliximab Biosimilar

   • Walter Reinisch
   • Stanley Cohen
   • Jean-Frederic Colombel

   Review Open access 10 November 2021 Pages: 44 - 57

   

5. Denosumab in the Treatment of Osteoporosis: 10 Years Later: A Narrative Review

   • David L. Kendler
   • Felicia Cosman
   • Serge Ferrari

   Review Open access 11 November 2021 Pages: 58 - 74

   

6. Value of Remission in Patients with Rheumatoid Arthritis: A Targeted Review

   • Andrew J. Ostor
   • Ruta Sawant
   • Keith A. Betts

   Review Open access 17 November 2021 Pages: 75 - 93

   

7. Effects of High-Intensity Interval Training on Pulmonary Function and Exercise Capacity in Individuals with Chronic Obstructive Pulmonary Disease: A Meta-Analysis and Systematic Review

   • Min Gao
   • Yangxi Huang
   • Guozhen Sun

   Review 18 November 2021 Pages: 94 - 116

   

8. Comparative Effectiveness and Safety of Open-Door Laminoplasty, French-Door Laminoplasty, Laminectomy and Fusion, and Laminectomy Alone for Multilevel Degenerative Cervical Myelopathy: A Bayesian Network Analysis

   • Xian Li
   • Hui Yu
   • Koroush Kabir

   Review 23 November 2021 Pages: 117 - 139

   

9. Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy

   • Tomasz Harężlak
   • Urszula Religioni
   • Piotr Merks

   Review Open access 29 November 2021 Pages: 140 - 147

10. Chronic Kidney Disease and SGLT2 Inhibitors: A Review of the Evolving Treatment Landscape

    • Christian W. Mende

    Review Open access 30 November 2021 Pages: 148 - 164

    

11. Clinical and Molecular Features of Patients with Gliomas Harboring IDH1 Non-canonical Mutations: A Systematic Review and Meta-Analysis

    • Vincenzo Di Nunno
    • Enrico Franceschi
    • Alba Ariela Brandes

    Review 01 December 2021 Pages: 165 - 177

    

12. The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review

    • Michael S. Blaiss
    • Jonathan A. Bernstein
    • Joseph Moellman

    Review Open access 04 December 2021 Pages: 178 - 192

    

13. Treatments for Chronic Kidney Disease: A Systematic Literature Review of Randomized Controlled Trials

    • Juan Jose Garcia Sanchez
    • Juliette Thompson
    • Keith R. Abrams

    Review Open access 08 December 2021 Pages: 193 - 220

    

14. Current Understanding of Narcolepsy 1 and its Comorbidities: What Clinicians Need to Know

    • Lois E. Krahn
    • Phyllis C. Zee
    • Michael J. Thorpy

    Review Open access 11 December 2021 Pages: 221 - 243

    

15. Treatment Persistence in Patients Cycling on Subcutaneous Tumor Necrosis Factor-Alpha Inhibitors in Inflammatory Arthritis: A Retrospective Study

    • Johan Dalén
    • Amy Puenpatom
    • Christopher M. Black

    Original Research 03 September 2021 Pages: 244 - 255

    

16. Correction to: Treatment Persistence in Patients Cycling on Subcutaneous Tumor Necrosis Factor-Alpha Inhibitors in Inflammatory Arthritis: A Retrospective Study

    • Johan Dalén
    • Amy Puenpatom
    • Christopher M. Black

    Correction 08 November 2021 Pages: 256 - 256

17. Nomograms for Predicting Overall Survival and Cancer-Specific Survival of Young Patients with Epithelial Ovarian Cancer: Analysis Based on SEER Program

    • Jian Gao
    • Shengtan Wang
    • Liancheng Zhu

    Original Research 29 October 2021 Pages: 257 - 285

    

18. The Efficacy of High- or Low-Frequency Transcranial Magnetic Stimulation in Alzheimer’s Disease Patients with Behavioral and Psychological Symptoms of Dementia

    • Wei Jiang
    • Zhenxia Wu
    • Yaxing Gui

    Original Research 29 October 2021 Pages: 286 - 295

    

19. Treatment Pattern for Advanced Gastric Cancer in Japan and Factors Associated with Sequential Treatment: A Retrospective Administrative Claims Database Study

    • Yoshito Komatsu
    • Shuichi Hironaka
    • Narikazu Boku

    Original Research Open access 29 October 2021 Pages: 296 - 313

    

20. Healthcare Resource Utilization, Cardiovascular Event Rate and Use of Lipid-Lowering Therapies in Secondary Prevention of ASCVD in Hospitalized Patients in Italy

    • Paolo Sciattella
    • Aldo P. Maggioni
    • Francesco S. Mennini

    Original Research Open access 31 October 2021 Pages: 314 - 327

    

21. Utilization of Poly(ADP-Ribose) Polymerase Inhibitors in Ovarian Cancer: A Retrospective Cohort Study of US Healthcare Claims Data

    • Rebecca C. Arend
    • David M. O’Malley
    • Gráinne H. Long

    Original Research Open access 02 November 2021 Pages: 328 - 345

    

22. Prognostic Nomogram for Overall Survival in Small Cell Lung Cancer Patients Treated with Chemotherapy: A SEER-Based Retrospective Cohort Study

    • Min Liang
    • Mafeng Chen
    • Shivank Singh

    Original Research 03 November 2021 Pages: 346 - 359

    

23. Human Epididymis Protein 4 and Lewis y Enhance Chemotherapeutic Resistance in Epithelial Ovarian Cancer Through the p38 MAPK Pathway

    • Jian Gao
    • Liancheng Zhu
    • Bei Lin

    Original Research 05 November 2021 Pages: 360 - 378

    

24. Effects of Lusutrombopag on Post-invasive Procedural Bleeding in Thrombocytopenic Patients with Chronic Liver Disease

    • Manami Yoshida
    • Ryosuke Tateishi
    • Ataru Igarashi

    Original Research Open access 08 November 2021 Pages: 379 - 390

    

25. Concomitant Treatment of Hypertensive Patients with Bisoprolol and Perindopril in Routine Clinical Practice: A Post Hoc Analysis of the CONFIDENCE II, PROTECT I, and PROTECT III Observational Studies

    • Murielle Abeel
    • Anil Gupta
    • Christian Constance

    Original Research Open access 10 November 2021 Pages: 391 - 404

    

26. Treatment of Idiopathic Pulmonary Fibrosis with Capsule or Tablet Formulations of Pirfenidone in the Real-Life French RaDiCo-ILD Cohort

    • Vincent Cottin
    • Sonia Guéguen
    • and the RaDiCo team

    Original Research 10 November 2021 Pages: 405 - 420

    

27. Influence of Fasting Plasma Glucose Targets on Glycemic Variability in Chinese Participants With Type 2 Diabetes: A Post Hoc Analysis of the FPG GOAL Trial (BEYOND III)

    • Ling Li
    • Tao Yang
    • Wenying Yang

    Original Research 10 November 2021 Pages: 421 - 429

28. May Previous Hepatitis B Virus Infection Be Involved in Etiology and Pathogenesis of Autoimmune Liver Diseases?

    • Sergey Batskikh
    • Sergey Morozov
    • Vladimir Chulanov

    Original Research 11 November 2021 Pages: 430 - 440

    

29. Prospective Prescription Review System Promotes Safe Use of Analgesics, Improves Clinical Outcomes, and Saves Medical Costs in Surgical Patients: Insights from Nanjing Drum Tower Hospital

    • Han Xie
    • Haixia Zhang
    • Weihong Ge

    Original Research Open access 13 November 2021 Pages: 441 - 454

    

30. The Economic Impact of Originator-to-Biosimilar Non-medical Switching in the Real-World Setting: A Systematic Literature Review

    • Erin Hillhouse
    • Karine Mathurin
    • Catherine Beauchemin

    Original Research Open access 15 November 2021 Pages: 455 - 487

    

31. Pharmacokinetics, Pharmacodynamics, and Safety of Dulaglutide After Single or Multiple Doses in Chinese Healthy Subjects and Patients with T2DM: A Randomized, Placebo-Controlled, Phase I Study

    • Junyu Xu
    • Yifei Zhang
    • Weiqing Wang

    Original Research 17 November 2021 Pages: 488 - 503

    

32. Effectiveness, Adherence, and Safety of Evolocumab in a Swiss Multicenter Prospective Observational Study

    • David Nanchen
    • David Carballo
    • Isabella Sudano

    Original Research Open access 18 November 2021 Pages: 504 - 517

    

33. Apalutamide Compared with Darolutamide for the Treatment of Non-metastatic Castration-Resistant Prostate Cancer: Efficacy and Tolerability in a Matching-Adjusted Indirect Comparison

    • Simon Chowdhury
    • Stephane Oudard
    • Boris A. Hadaschik

    Original Research Open access 19 November 2021 Pages: 518 - 531

    

34. The Short-Term Efficacy and Safety of Brentuximab Vedotin Plus Cyclophosphamide, Epirubicin and Prednisone in Untreated PTCL: A Real-World, Retrospective Study

    • Xiaomeng Feng
    • Wei Guo
    • Ou Bai

    Original Research Open access 19 November 2021 Pages: 532 - 543

    

35. Long-Term Safety and Clinical Outcomes with Insulin Degludec/Insulin Aspart Treatment in Japanese Patients with Diabetes: A Real-World, Prospective, Observational Study

    • Takuyuki Katabami
    • Kirsten T. Eriksen
    • Yasushi Ishigaki

    Original Research Open access 20 November 2021 Pages: 544 - 561

    

36. Cost-Effectiveness of Combination of Baricitinib and Remdesivir in Hospitalized Patients with COVID-19 in the United States: A Modelling Study

    • Kari Kelton
    • Tim Klein
    • Russel Burge

    Original Research Open access 22 November 2021 Pages: 562 - 582

    

37. Efficacy and Safety of HLX03, an Adalimumab Biosimilar, in Patients with Moderate-to-Severe Plaque Psoriasis: A Randomized, Double-Blind, Phase III Study

    • Lin Cai
    • Linfeng Li
    • Jianzhong Zhang

    Original Research Open access 23 November 2021 Pages: 583 - 597

    

38. Population Pharmacokinetics and Exposure–Response Analyses for Venetoclax in Combination with R-CHOP in Relapsed/Refractory and Previously Untreated Patients with Diffuse Large B Cell Lymphoma

    • Divya Samineni
    • Weize Huang
    • Dale Miles

    Original Research Open access 25 November 2021 Pages: 598 - 618

    

39. A Qualitative Study to Characterize the Humanistic Burden of Kabuki Syndrome in the United States and Canada

    • Christina Theodore-Oklota
    • Deborah S. Hartman
    • Hans T. Björnsson

    Original Research Open access 29 November 2021 Pages: 619 - 631

    

40. Efficacy and Safety of Metformin Versus the Other Oral Antidiabetic Drugs in Japanese Type 2 Diabetes Patients: A Network Meta-analysis

    • Rimei Nishimura
    • Mayumi Taniguchi
    • Kosuke Iwasaki

    Original Research Open access 30 November 2021 Pages: 632 - 654

    

41. Clinical Implications of Nicorandil Combined with Trimetazidine in Patients with Coronary Heart Disease: A Real-World Observational Study

    • Lan Shen
    • Lin Qiu
    • Ning Zhou

    Original Research 30 November 2021 Pages: 655 - 673

    

42. Real-World Safety and Effectiveness of Canagliflozin Treatment for Type 2 Diabetes Mellitus in Japan: SAPPHIRE, a Long-Term, Large-Scale Post-Marketing Surveillance

    • Nobuya Inagaki
    • Masaomi Nangaku
    • Koume Hamada

    Original Research Open access 02 December 2021 Pages: 674 - 691

    

43. Ubrogepant Is Safe and Efficacious in Participants Taking Concomitant Preventive Medication for Migraine: A Pooled Analysis of Phase 3 Trials

    • Andrew M. Blumenfeld
    • Kerry Knievel
    • David W. Dodick

    Original Research Open access 07 December 2021 Pages: 692 - 705

    

44. Pharmacology Versus Convenience: A Benefit/Risk Analysis of Regular Maintenance Versus Infrequent or As-Needed Inhaled Corticosteroid Use in Mild Asthma

    • Peter Daley-Yates
    • Bhumika Aggarwal
    • Dave Singh

    Original Research Open access 07 December 2021 Pages: 706 - 726

    

45. An Economic Analysis of Critical Care Nurse Resourcing Following the Uptake of Ready-to-Administer Noradrenaline for Hypotensive Shock in Adults in England

    • Edward Griffin
    • Oliver Tweedie
    • Justin Kirk-Bayley

    Original Research Open access 07 December 2021 Pages: 727 - 737

    

46. Risk of Thromboembolic Events and Associated Healthcare Costs in Patients with Inflammatory Bowel Disease

    • Juliana Setyawan
    • Fan Mu
    • Andres Yarur

    Original Research Open access 07 December 2021 Pages: 738 - 753

    

47. Comparison of Net Clinical Benefit Between Clopidogrel and Ticagrelor Following Percutaneous Coronary Intervention in Patients in China With Acute Coronary Syndrome

    • Dandan Li
    • Yang Sun
    • Daowen Wang

    Original Research 13 December 2021 Pages: 754 - 766

    

48. The Economic Burden of Thromboembolic Events Among Patients with Immune-Mediated Diseases

    • Juliana Setyawan
    • Emma Billmyer
    • Vibeke Strand

    Original Research Open access 14 December 2021 Pages: 767 - 778

    

49. Comparative Effectiveness of Persistent Use of a Name-Brand Levothyroxine (Synthroid®) vs. Persistent Use of Generic Levothyroxine on TSH Goal Achievement: A Retrospective Study Among Patients with Hypothyroidism in a Managed Care Setting

    • Liya Wang
    • Yaozhu J. Chen
    • James V. Hennessey

    Original Research Open access 14 December 2021 Pages: 779 - 795

    

50. Long-Term Survival, Safety and Tolerability with Selexipag in Patients with Pulmonary Arterial Hypertension: Results from GRIPHON and its Open-Label Extension

    • Nazzareno Galiè
    • Sean Gaine
    • Kelly M. Chin

    Brief Report Open access 30 October 2021 Pages: 796 - 810