“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy Bart HensMaura CorsettiAlexis Aceituno Meeting Report 06 June 2019 Article: 75
A Bounded Integer Model for Rating and Composite Scale Data Gustaf J. WellhagenMaria C. KjellssonMats O. Karlsson Research Article Open access 06 June 2019 Article: 74
Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART® Alison BettsNahor Haddish-BerhaneXiaoying Chen Correction 04 June 2019 Article: 73
Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices Jane P. F. BaiJustin C. EarpVenkateswaran C. Pillai Review Article 03 June 2019 Article: 72
Anti-drug Antibody Assay Conditions Significantly Impact Assay Screen and Confirmatory Cut-Points Boris GorovitsYing WangChristopher Lepsy Research Article 03 June 2019 Article: 71
Skin Delivery and Irritation Potential of Phenmetrazine as a Candidate Transdermal Formulation for Repurposed Indications Ying JiangKevin S. MurnaneAjay K. Banga Research Article 31 May 2019 Article: 70
Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data Rui Li Research Article 28 May 2019 Article: 69
Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates Wojciech KrzyzanskiSarah F. CookJohn N. van den Anker Research Article 28 May 2019 Article: 68
Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity Jean-Marie NicolasElizabeth C. M. de Lange Review Article 28 May 2019 Article: 67
A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART® Alison BettsNahor Haddish-BerhaneXiaoying Chen Research Article Open access 22 May 2019 Article: 66
Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension Maxime Le MerdyJianghong FanLiang Zhao Research Article 20 May 2019 Article: 65
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy Quoc-Viet LeJuhan SuhYu-Kyoung Oh Review Article 17 May 2019 Article: 64
In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues Anders Bork DavidsenMarie MardalKristian Linnet Research Article 15 May 2019 Article: 63
Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity H. A. Daniel LagasséHartmut HengelZuben E. Sauna Research Article 06 May 2019 Article: 62
Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography Irene Hernández LozanoRudolf KarchOliver Langer Research Article Open access 29 April 2019 Article: 61
A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT® Daily Diary Data from COPD Patients Eva GermovsekClaire AmberyElodie L. Plan Research Article Open access 26 April 2019 Article: 60
Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery Pui Shan ChanJia Wen XianKenneth K. W. To Research Article 24 April 2019 Article: 59
Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol—an Interaction Study in Healthy Volunteers Caroline GjestadKristine HoleEspen Molden Research Article 24 April 2019 Article: 58
Targeting Cancer Via Resveratrol-Loaded Nanoparticles Administration: Focusing on In Vivo Evidence Ana Cláudia SantosIrina PereiraFrancisco Veiga Review Article 23 April 2019 Article: 57
Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials” Jon S. B. de VliegerDaan J. A. CrommelinVinod P. Shah Meeting Report Open access 17 April 2019 Article: 56
Report on the AAPS Immunogenicity Guidance Forum Heather MylerBoris GorovitsVinod P. Shah Meeting Report 16 April 2019 Article: 55
In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate Ahmed Fouad Abdelwahab MohammedTaishi HigashiHidetoshi Arima Research Article 16 April 2019 Article: 54
Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice Syedsaoud ZaidiMong-Jen ChenGünther Hochhaus Research Article 16 April 2019 Article: 53