Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment D. GoutyC. C. CaiC. Satterwhite White Paper Open access 28 December 2017 Article: 25
Adaptive Optimal Designs for Dose-Finding Studies with Time-to-Event Outcomes Yevgen RyeznikOleksandr SverdlovAndrew C. Hooker Research Article Open access 28 December 2017 Article: 24
Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling Qianwen WangYufeng ZhangZhong Zuo Research Article 27 December 2017 Article: 23
Calibration Curves in Quantitative Ligand Binding Assays: Recommendations and Best Practices for Preparation, Design, and Editing of Calibration Curves Mitra AzadehBoris GorovitsPerceval Sondag White Paper Open access 27 December 2017 Article: 22
The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution Melanie A. FelmleeBridget L. MorseMarilyn E. Morris Research Article 26 December 2017 Article: 21
Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety Jose Meseguer-RipollesSalman R. KhetaniDavid C. Hay Mini-Review Open access 21 December 2017 Article: 20
In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention Christina N. RamirezWenji LiAh-Ng Kong Review Article 20 December 2017 Article: 19
Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia Dharani ManickavasagamKimberly NovakMoses O. Oyewumi Research Article 14 December 2017 Article: 18
Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research Jonathan P. MochelAlbert E. JergensKarin Allenspach Commentary Open access 12 December 2017 Article: 17
Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [18F]Fluorothymidine Using PET Imaging Laura L. Boles PontoJiangeng HuangMaureen Donovan Research Article 07 December 2017 Article: 16
Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration Laura L. Boles PontoSusan WalshMaureen Donovan Research Article 07 December 2017 Article: 15
Balancing Antibacterial Efficacy and Reduction in Renal Function to Optimise Initial Gentamicin Dosing in Paediatric Oncology Patients Carolina Consuelo Llanos-PaezChristine StaatzStefanie Hennig Research Article 04 December 2017 Article: 14
Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins Takeo NakanishiIkumi Tamai Review Article 04 December 2017 Article: 13
The Na+/Cl−-Coupled, Broad-Specific, Amino Acid Transporter SLC6A14 (ATB0,+): Emerging Roles in Multiple Diseases and Therapeutic Potential for Treatment and Diagnosis Mohd Omar F. SikderShengping YangYangzom D. Bhutia Review Article 04 December 2017 Article: 12
Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling Anna H. C. VlotWilhelmus E. A. de WitteElizabeth C. M. de Lange Research Article Open access 04 December 2017 Article: 11
A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective Allison Given ChunykAlison JoyceDavid Yeung Research Article 01 December 2017 Article: 10
Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level Verena SchneiderSelim ChaibGanna V. Kalayda Research Article 30 November 2017 Article: 9
ABCB6, an ABC Transporter Impacting Drug Response and Disease Rebba C. Boswell-CasteelYu FukudaJohn D. Schuetz Review Article 30 November 2017 Article: 8
A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy Richard S. RogersMichael AbernathyRohini Deshpande Commentary Open access 30 November 2017 Article: 7
Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram Nikunjkumar PatelBarbara WiśniowskaSebastian Polak Research Article Open access 27 November 2017 Article: 6
Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models Sebastiaan C. GouloozePyry A. J. VälitaloElke H. J. Krekels Research Article Open access 27 November 2017 Article: 5
Pharmacogenomic Biomarkers for Improved Drug Therapy—Recent Progress and Future Developments Volker M. LauschkeLili MilaniMagnus Ingelman-Sundberg Review Article Open access 27 November 2017 Article: 4
Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats Xirong ZhengZiyuan ZhouFang Zheng Research Article 27 November 2017 Article: 3
Selection and Qualification of Simplified QSP Models When Using Model Order Reduction Techniques Chihiro HasegawaStephen B. Duffull Research Article 27 November 2017 Article: 2
Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications Anjana JeyaramSteven M. Jay Mini-Review 27 November 2017 Article: 1