Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints Anders VibergGiovanni MartinoJennifer M. A. Laird Research Article 19 June 2012 Pages: 657 - 663
Statistics on BCS Classification of Generic Drug Products Approved Between 2000 and 2011 in the USA Anil K. NairOm AnandBarbara M. Davit Regulatory Note 21 June 2012 Pages: 664 - 666
Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers Jagdeep ShurSau LeeRobert Price Research Article 22 June 2012 Pages: 667 - 676
Crystalline Nanosuspensions as Potential Toxicology and Clinical Oral Formulations for BCS II/IV Compounds Filippos KesisoglouAmitava Mitra Review Article 27 June 2012 Pages: 677 - 687
Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration? Roudayna DiabChiraz Jaafar-MaalejPhilippe Maincent Review Article 06 July 2012 Pages: 688 - 702
Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs Ping GaoYi Shi Review Article 14 July 2012 Pages: 703 - 713
Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions Yulia VugmeysterJohn HarroldXin Xu Review Article 14 July 2012 Pages: 714 - 727
Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry Robert ErbKatharina LeithnerHerbert Oberacher Research Article Open access 18 July 2012 Pages: 728 - 737
Bioequivalence Requirements in the European Union: Critical Discussion Alfredo García-ArietaJohn Gordon Review Article 24 July 2012 Pages: 738 - 748
Guidelines for the Quality Control of Population Pharmacokinetic–Pharmacodynamic Analyses: an Industry Perspective P. L. BonateA. StrougoS. Tannenbaum Review Article 24 July 2012 Pages: 749 - 758
Drug Repurposing: Far Beyond New Targets for Old Drugs T. I. OpreaJ. Mestres Commentary 24 July 2012 Pages: 759 - 763
Rationalizing Structure and Target Relationships between Current Drugs Ye HuJürgen Bajorath Research Article 24 July 2012 Pages: 764 - 771
A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS Buyun ChenMichael Bartlett Research Article 28 July 2012 Pages: 772 - 780
Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics Xin XuYulia Vugmeyster Review Article 04 August 2012 Pages: 781 - 791
International Veterinary Bioequivalence Guideline Similarities and Differences Between Australia, Canada, Europe, Japan, New Zealand and the United States Chantal Lainesse Review Article 04 August 2012 Pages: 792 - 798
ADME of Antibody–Maytansinoid Conjugates Hans K. EricksonJohn M. Lambert Review Article 09 August 2012 Pages: 799 - 805
Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site Diar MohammedPaul J. MattsMajella E. Lane Research Article 18 August 2012 Pages: 806 - 812
Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations Laszlo EndrenyiLaszlo Tothfalusi Review Article Open access 22 August 2012 Pages: 813 - 819
Monoamine Transporter Structure, Function, Dynamics, and Drug Discovery: A Computational Perspective Sankar ManepalliChristopher K. SurrattTammy L. Nolan Review Article 24 August 2012 Pages: 820 - 831
Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells Aswani Dutt VadlapudiRamya Krishna VadlapatlaAshim K. Mitra Research Article 18 August 2012 Pages: 832 - 842
Universal Immunoassay Applied During Early Development of Large Molecules to Understand Impact of Immunogenicity on Biotherapeutic Exposure Ami C. BautistaHossein Salimi-MoosaviVibha Jawa Research Article 01 September 2012 Pages: 843 - 849
Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn Yang ChenJoseph P. Balthasar Research Article 07 September 2012 Pages: 850 - 859
Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development Nicky ThomasRené HolmAnette Müllertz Review Article 07 September 2012 Pages: 860 - 871
Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice Darlene M. RozewskiSarah E. M. HermanMitch A. Phelps Research Article 07 September 2012 Pages: 872 - 882
Regulatory Pathways for ATP-binding Cassette Transport Proteins in Kidney Proximal Tubules Rosalinde MasereeuwFrans G. M. Russel Review Article 08 September 2012 Pages: 883 - 894
Effective Absorption Modeling in Relative Bioavailability Study Risk Assessment John P. Rose Review Article 11 September 2012 Pages: 895 - 903
Semi-mechanistic Modeling of the Interaction Between the Central and Peripheral Effects in the Antinociceptive Response to Lumiracoxib in Rats Nieves Vélez de MendizábalDalia Vásquez-BahenaIñaki F. Trocóniz Research Article 12 September 2012 Pages: 904 - 914
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Generic Drug Products by the US Food and Drug Administration Barbara M. DavitMei-Ling ChenLawrence X. Yu Review Article 13 September 2012 Pages: 915 - 924
Use of Partial Area under the Curve Metrics to Assess Bioequivalence of Methylphenidate Multiphasic Modified Release Formulations Ethan M. StierBarbara M. DavitDale P. Conner Regulatory Note 14 September 2012 Pages: 925 - 926
Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact Xu Steven XuMin YuanAn Vermeulen Research Article 20 September 2012 Pages: 927 - 936