A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model Emilie HĂ©ninMartin BergstrandMats O. Karlsson Research Article 28 January 2012 Pages: 155 - 163
Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory Leslie Z. Benet Commentary 03 February 2012 Pages: 164 - 167
Population Analyses of Efficacy and Safety of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain Sandeep DuttaBalakrishna S. HosmaneWalid M. Awni Research Article 11 February 2012 Pages: 168 - 175
Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models Camille VongMartin BergstrandMats O. Karlsson Research Article 17 February 2012 Pages: 176 - 186
Cutaneous Microdialysis: Cytokine Evidence for Altered Innate Reactivity in the Skin of Psoriasis Patients? Florence SjögrenKarin DavidssonChris D. Anderson Research Article 29 February 2012 Pages: 187 - 195
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs Paul A. DickinsonRagheb Abu RmailehMohammed Yasin Research Paper 29 February 2012 Pages: 196 - 205
Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting Caroline WatsonJoshua S. Sharp Research Article 02 March 2012 Pages: 206 - 217
Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits Yanjun ZhaoMarc B. BrownStuart A. Jones Research Article 01 March 2012 Pages: 218 - 224
Design and Characterization of Novel Peptide-Coated Lipid Nanoparticles for Targeting Anti-HIV Drug to CD4 Expressing Cells Aaron N. EndsleyRodney J. Y. Ho Research Article 06 March 2012 Pages: 225 - 235
Issues and Challenges of Subvisible and Submicron Particulate Analysis in Protein Solutions Thomas M. SchererStephenie LeungSteven J. Shire Research Article 06 March 2012 Pages: 236 - 243
The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs Arik DahanJonathan M. Miller Research Article 06 March 2012 Pages: 244 - 251
Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice Fang WuMitalee TamhaneMarilyn E. Morris Research Article 06 March 2012 Pages: 252 - 261
Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation Peng ZouYanke YuDuxin Sun Review Article 10 March 2012 Pages: 262 - 281
Challenges in Development of Nanoparticle-Based Therapeutics Neil Desai Review Article Open access 10 March 2012 Pages: 282 - 295
Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy Narendra ChirmuleVibha JawaBernd Meibohm Review Article 10 March 2012 Pages: 296 - 302
Challenges in Development of Targeted Liposomal Therapeutics Rupa R. SawantVladimir P. Torchilin Review Article 14 March 2012 Pages: 303 - 315
Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents Denise M. O’HaraValerie TheobaldJeannine Keefe White Paper 14 March 2012 Pages: 316 - 328
Role of Metabolism in the Effects of Genistein and Its Phase II Conjugates on the Growth of Human Breast Cell Lines Bo YuanLinglan WangHaiyan Xu Research Article 14 March 2012 Pages: 329 - 344
Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters Min ZhangJin YangJohn Paul Fawcett Research Article 15 March 2012 Pages: 345 - 351
A Physiologically Based Pharmacokinetic Model of Mitoxantrone in Mice and Scale-up to Humans: a Semi-Mechanistic Model Incorporating DNA and Protein Binding Guohua AnMarilyn E. Morris Research Article 27 March 2012 Pages: 352 - 364
Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Rat Prefrontal Cortical Dopamine Response to Dual Acting Norepinephrine Reuptake Inhibitor and 5-HT1A Partial Agonist Cheryl Shuang-wu LiLiming ZhangBrian Campbell Research Article 28 March 2012 Pages: 365 - 376