Correction to: Metabolic Profile of 3-Acetyl-11-Keto-β-Boswellic Acid and 11-Keto-β-Boswellic Acid in Human Preparations In Vitro, Species Differences, and Bioactivity Variation Yonglei CuiXiangge TianXiaochi Ma Correction 14 August 2019 Article: 100
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System Marilyn N. MartinezAyman El-KattanMark Papich Research Article 08 August 2019 Article: 99
Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents Wei JinMays Al-DulaymiAnas El-Aneed Research Article 06 August 2019 Article: 98
Evaluation of Assumptions Underpinning Pharmacometric Models Qing-Xi OoiDaniel F. B. WrightStephen B. Duffull Research Article 05 August 2019 Article: 97
TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity Osman N. YogurtcuZuben E. SaunaHong Yang Research Article 02 August 2019 Article: 96
Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models Theodoros PapathanasiouAnders StratheAndrew C. Hooker Research Article 29 July 2019 Article: 95
Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1 Lora HamuroGiridhar S. TirucheraiCraig J. Thalhauser Research Article 24 July 2019 Article: 94
Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats Ruihong YuDawei SongWilliam J. Jusko Research Article 24 July 2019 Article: 93
A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance Uma KavitaWendy MillerRenuka C. Pillutla Research Article 22 July 2019 Article: 92
Model-Informed Drug Development Approach Supporting Approval of Adalimumab (HUMIRA) in Adolescent Patients with Hidradenitis Suppurativa: a Regulatory Perspective Youwei BiJiang LiuYaning Wang Regulatory Note 19 July 2019 Article: 91
Reduced Systemic and Brain Exposure with Inhibited Liver Metabolism of Carbamazepine After Its Long-Term Combination Treatment with Piperine for Epilepsy Control in Rats Tianjing RenMin XiaoZhong Zuo Research Article 18 July 2019 Article: 90
Quality Controls in Ligand Binding Assays: Recommendations and Best Practices for Preparation, Qualification, Maintenance of Lot to Lot Consistency, and Prevention of Assay Drift Mitra AzadehPerceval SondagJeffrey Sailstad White Paper Open access 11 July 2019 Article: 89
Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples Cindy Yanfei LiChelsea Hosey-CojocariBhagwat Prasad Research Article 11 July 2019 Article: 88
Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar Sandeep K. MisraRon OrlandoJoshua S. Sharp Research Article 11 July 2019 Article: 87
A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation Guor-Jien WeiYen-Hsiang ChaoZheng-Yuan Su Research Article 10 July 2019 Article: 86
Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies Ari BrekkanLuis Lopez-LazaroMats O. Karlsson Research Article Open access 08 July 2019 Article: 85
Characterization and Quantification of an Fc-FGF21 Fusion Protein in Rat Serum Using Immunoaffinity LC-MS Fengping LiYan WengHendrik Neubert Research Article 08 July 2019 Article: 84
Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway Hsiao-Chen Dina KuoRenyi WuAh-Ng Kong Research Article 28 June 2019 Article: 83
Determination of IL-23 Pharmacokinetics by Highly Sensitive Accelerator Mass Spectrometry and Subsequent Modeling to Project IL-23 Suppression in Psoriasis Patients Treated with Anti-IL-23 Antibodies Ting-Ting ZhangJunli MaJ. Cory Kalvass Research Article 27 June 2019 Article: 82
A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children Janneke M. BrusseeElke H. J. KrekelsCatherijne A. J. Knibbe Research Article Open access 27 June 2019 Article: 81
Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation Satoshi UeshimaDaiki HiraToshiya Katsura Research Article 24 June 2019 Article: 80
A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer Mohammad JafarnejadChang GongAleksander S. Popel Research Article Open access 24 June 2019 Article: 79
Guidance for Rifampin and Midazolam Dosing Protocols To Study Intestinal and Hepatic Cytochrome P450 (CYP) 3A4 Induction and De-induction Asha J KapetasMichael J SorichAndrew Rowland Research Article 19 June 2019 Article: 78
Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies Andrea TreyerMohammed UllahPer Artursson Research Article Open access 18 June 2019 Article: 77
Anti-drug Antibody Assay Validation: Improved Reporting of the Assay Selectivity via Simpler Positive Control Recovery Data Analysis Boris GorovitsMarcela Araya RoldanYing Wang Research Article 18 June 2019 Article: 76
