1. Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

   • Mitchel J. R. Ruigrok
   • Elizabeth C. M. de Lange

   Review Article Open access 19 February 2015 Pages: 493 - 505

   

2. Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health

   • Jeffrey N. Bryan

   Review Article 19 February 2015 Pages: 506 - 512

3. Does the Recent Growth of Aquaculture Create Antibiotic Resistance Threats Different from those Associated with Land Animal Production in Agriculture?

   • Hansa Y. Done
   • Arjun K. Venkatesan
   • Rolf U. Halden

   Review Article 21 February 2015 Pages: 513 - 524

   

4. Antibody Drug Conjugates: Preclinical Considerations

   • Gadi G. Bornstein

   Review Article 28 February 2015 Pages: 525 - 534

   

5. Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

   • Nilay Thakkar
   • A. Craig Lockhart
   • Wooin Lee

   Review Article 04 March 2015 Pages: 535 - 545

6. International Guidelines for Bioequivalence of Locally Acting Orally Inhaled Drug Products: Similarities and Differences

   • Dongmei Lu
   • Sau L. Lee
   • Bing V. Li

   Review Article 11 March 2015 Pages: 546 - 557

   

7. Human Health Relevance of Pharmaceutically Active Compounds in Drinking Water

   • Usman Khan
   • Jim Nicell

   Research Article 05 March 2015 Pages: 558 - 585

   

8. Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats

   • Jacob Leander
   • Joachim Almquist
   • Mats Jirstrand

   Research Article Open access 19 February 2015 Pages: 586 - 596

   

9. Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

   • Adrien Tessier
   • Julie Bertrand
   • Emmanuelle Comets

   Research Article 20 February 2015 Pages: 597 - 608

   

10. Structural and Activity Profile Relationships Between Drug Scaffolds

    • Ye Hu
    • Jürgen Bajorath

    Research Article 20 February 2015 Pages: 609 - 619

    

11. Mesenchymal Stromal/Stem Cell and Minocycline-Loaded Hydrogels Inhibit the Growth of Staphylococcus aureus that Evades Immunomodulation of Blood-Derived Leukocytes

    • Alberto Daniel Guerra
    • David Antonio Cantu
    • Weiyuan John Kao

    Research Article 26 February 2015 Pages: 620 - 630

    

12. Development of a Novel Oral Cavity Compartmental Absorption and Transit Model for Sublingual Administration: Illustration with Zolpidem

    • Binfeng Xia
    • Zhen Yang
    • Filippos Kesisoglou

    Research Article 26 February 2015 Pages: 631 - 642

    

13. Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control

    • Kui Zeng
    • Ilan Geerlof-Vidavisky
    • Michael T. Boyne II

    Research Article 26 February 2015 Pages: 643 - 651

    

14. Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on ¹⁸F-2-Fluoro-2-Deoxy-d-glucose (¹⁸F-FDG) Brain Kinetics

    • Nicolas Tournier
    • Wadad Saba
    • Salvatore Cisternino

    Research Article 26 February 2015 Pages: 652 - 659

    

15. Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

    • Ariane Wohlfarth
    • Marisol S. Castaneto
    • Marilyn A. Huestis

    Research Article 28 February 2015 Pages: 660 - 677

    

16. Pilot and Repeat Trials as Development Tools Associated with Demonstration of Bioequivalence

    • Anders Fuglsang

    Research Article 04 March 2015 Pages: 678 - 683

    

17. In Silico Evaluation of the Potential Impact of Bioanalytical Bias Difference between Two Therapeutic Protein Formulations for Pharmacokinetic Assessment in a Biocomparability Study

    • Theingi M. Thway
    • Chris Macaraeg
    • Mark Ma

    Research Article 05 March 2015 Pages: 684 - 690

    

18. Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: a Comparison by Simulation of Two-Stage and Joint Approaches

    • Solène Desmée
    • France Mentré
    • Jérémie Guedj

    Research Article 05 March 2015 Pages: 691 - 699

    

19. Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice

    • Mingming Gao
    • Chunbo Zhang
    • Dexi Liu

    Research Article 05 March 2015 Pages: 700 - 710

    

20. Lipidomics Revealed Idiopathic Pulmonary Fibrosis-Induced Hepatic Lipid Disorders Corrected with Treatment of Baicalin in a Murine Model

    • Changfeng Hu
    • Yiqi Wang
    • Chengping Wen

    Research Article 12 March 2015 Pages: 711 - 722

    

21. Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

    • Peimin Dai
    • Lijun Zhu
    • Zhongqiu Liu

    Research Article 12 March 2015 Pages: 723 - 736

    

22. Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family

    • Zhiwei Feng
    • Shifan Ma
    • Xiang-Qun Xie

    Research Article 12 March 2015 Pages: 737 - 753

    

23. Safety of β2-Agonists in Asthma: Linking Mechanisms, Meta-Analyses and Regulatory Practice

    • Sanjeeva. B. Dissanayake

    Meeting Report 25 February 2015 Pages: 754 - 757

24. Pharmacodynamic Studies to Demonstrate Bioequivalence of Oral Inhalation Products

    • Leslie Hendeles
    • Peter T. Daley-Yates
    • Stephen T. Horhota

    Meeting Report 26 February 2015 Pages: 758 - 768

    

25. Pharmacokinetics of Orally Inhaled Drug Products

    • Günther Hochhaus
    • Stephen Horhota
    • Juliet Rebello

    Meeting Report 12 March 2015 Pages: 769 - 775