1. Coexistence of Passive and Proton Antiporter-Mediated Processes in Nicotine Transport at the Mouse Blood–Brain Barrier

   • Salvatore Cisternino
   • Hélène Chapy
   • Jean-Michel Scherrmann

   Research Article 05 December 2012 Pages: 299 - 307

   

2. External Validation of the Bilirubin–Atazanavir Nomogram for Assessment of Atazanavir Plasma Exposure in HIV-1-Infected Patients

   • Dinko Rekić
   • Daniel Röshammar
   • Angela Äbelö

   Research Article Open access 07 December 2012 Pages: 308 - 315

   

3. Pharmacokinetics of Levodopa, Carbidopa, and 3-O-Methyldopa Following 16-hour Jejunal Infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients

   • Dag Nyholm
   • Per Odin
   • Ahmed A. Othman

   Research Article 11 December 2012 Pages: 316 - 323

   

4. Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

   • Kwok Kin Cheng
   • Chin Fung Yeung
   • Larry Baum

   Research Article 11 December 2012 Pages: 324 - 336

   

5. Simultaneous Analysis of Multiple Monoclonal Antibody Biotherapeutics by LC-MS/MS Method in Rat Plasma Following Cassette-Dosing

   • Hongyan Li
   • Robert Ortiz
   • Jean W. Lee

   Research Article 12 December 2012 Pages: 337 - 346

   

6. The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane

   • Arik Dahan
   • Avital Beig
   • Jonathan M Miller

   Research Article 15 December 2012 Pages: 347 - 353

   

7. Translational Pharmacokinetic-Pharmacodynamic Modeling from Nonclinical to Clinical Development: A Case Study of Anticancer Drug, Crizotinib

   • Shinji Yamazaki

   Review Article 19 December 2012 Pages: 354 - 366

   

8. Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells

   • Yoon Shin Park
   • Allan E. David
   • Victor C. Yang

   Research Article 19 December 2012 Pages: 367 - 376

   

9. Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches

   • Hannah M. Jones
   • Kapil Mayawala
   • Patrick Poulin

   Review Article 27 December 2012 Pages: 377 - 387

   

10. Regulatory Administrative Databases in FDA's Center for Biologics Evaluation and Research: Convergence Toward a Unified Database

    • Jeffrey K. Smith

    Commentary 27 December 2012 Pages: 388 - 394

    

11. TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

    • Lirong Wang
    • Chao Ma
    • Xiang-Qun Xie

    Research Article 05 January 2013 Pages: 395 - 406

    

12. Improper Selection of a Pre-specified Primary Dose–Response Analysis Delays Regulatory Drug Approval

    • Jiang Liu
    • Pravin Jadhav
    • Jogarao Gobburu

    Research Article 10 January 2013 Pages: 407 - 414

    

13. In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates

    • Sylvain Goutelle
    • Laurent Bourguignon
    • Genophar II Working Group

    Research Article 15 January 2013 Pages: 415 - 426

    

14. Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside

    • Jane P. F. Bai
    • Alexander V. Alekseyenko
    • Peggy H. Wong

    Review Article 15 January 2013 Pages: 427 - 437

    

15. Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

    • Erin Teeple
    • Gregory D. Jay
    • Braden C. Fleming

    Review Article 18 January 2013 Pages: 438 - 446

16. Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants

    • Jane P. F. Bai
    • Jeffrey S. Barrett
    • Lynne Yao

    Review Article 19 January 2013 Pages: 447 - 454

17. A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam

    • A. R. Maharaj
    • J. S. Barrett
    • A. N. Edginton

    Research Article 24 January 2013 Pages: 455 - 464

    

18. A Sensitivity Analysis of the Modified Chi-square Ratio Statistic for Equivalence Testing of Aerodynamic Particle Size Distribution

    • Benjamin Weber
    • Sau L. Lee
    • Guenther Hochhaus

    Research Article 24 January 2013 Pages: 465 - 476

    

19. The Interaction of Fatty Acid Amide Hydrolase (FAAH) Inhibitors with an Anandamide Carrier Protein Using ¹⁹ F-NMR

    • Jianqin Zhuang
    • De-Ping Yang
    • Alexandros Makriyannis

    Research Article 24 January 2013 Pages: 477 - 482

    

20. Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

    • Caroline A. Larregieu
    • Leslie Z. Benet

    Research Article 24 January 2013 Pages: 483 - 497

    

21. Simultaneous Pharmacokinetic Model for Rolofylline and both M1-trans and M1-cis Metabolites

    • Mark Stroh
    • Matthew M. Hutmacher
    • Julie Stone

    Research Article 25 January 2013 Pages: 498 - 504

    

22. Chemical Imaging of Drug Delivery Systems with Structured Surfaces–a Combined Analytical Approach of Confocal Raman Microscopy and Optical Profilometry

    • Birthe Kann
    • Maike Windbergs

    Research Article 29 January 2013 Pages: 505 - 510

    

23. Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer^® Foradile^®

    • Qi Tony Zhou
    • Zhenbo Tong
    • Hak-Kim Chan

    Research Article 01 February 2013 Pages: 511 - 522

    

24. Nonaqueous Gel for the Transdermal Delivery of a DTPA Penta-ethyl Ester Prodrug

    • Yong Zhang
    • Matthew P. Sadgrove
    • Michael Jay

    Research Article 07 February 2013 Pages: 523 - 532

    

25. Predictions of In Vivo Prolactin Levels from In Vitro K _i Values of D₂ Receptor Antagonists Using an Agonist–Antagonist Interaction Model

    • Klas J. Petersson
    • An M. Vermeulen
    • Lena E. Friberg

    Research Article 08 February 2013 Pages: 533 - 541

    

26. Modeling NSCLC Progression: Recent Advances and Opportunities Available

    • Ahmed Abbas Suleiman
    • Lucia Nogova
    • Uwe Fuhr

    Review Article 13 February 2013 Pages: 542 - 550

    

27. Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies

    • Kenneth T. Luu
    • Eugenia Kraynov
    • Wei-Zhu Zhong

    Review Article 14 February 2013 Pages: 551 - 558

    

28. Population-Based Efficacy Modeling of Omalizumab in Patients with Severe Allergic Asthma Inadequately Controlled with Standard Therapy

    • Rui Zhu
    • Yanan Zheng
    • David Z. D’Argenio

    Research Article 15 February 2013 Pages: 559 - 570

    

29. Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects

    • Hwa Yoon
    • Hea-Young Cho
    • Yong-Bok Lee

    Research Article 16 February 2013 Pages: 571 - 580

    

30. Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney

    • Hideyuki Motohashi
    • Ken-ichi Inui

    Review Article 22 February 2013 Pages: 581 - 588

    

31. Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

    • Moran Fairstein
    • Rotem Swissa
    • Arik Dahan

    Research Article 26 February 2013 Pages: 589 - 597

    

32. The Challenges of Assessing Osteoarthritis and Postoperative Pain in Dogs

    • Michele Sharkey

    Review Article 02 March 2013 Pages: 598 - 607

33. In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

    • Po-Chang Chiang
    • Yong Cui
    • Harvey Wong

    Research Article 02 March 2013 Pages: 608 - 617

    

34. Direct and Rapid Genotyping of SLCO1B1 388A>G and 521T>C in Human Blood Specimens Using the SmartAmp-2 Method

    • Kenta Yoshida
    • Junichi Takano
    • Yuichi Sugiyama

    Brief/Technical Note 08 March 2013 Pages: 618 - 622