1. Drug discovery for Alzheimer’s disease

   • Lorenzo M. Refolo
   • Howard M. Fillit

   Introduction Pages: 1 - 8

2. Neurocognitive aging and cardiovascular fitness

   • Stan J. Colcombe
   • Arthur F. Kramer
   • Paige Scalf

   Prevention Pages: 9 - 14

3. Cell cultures from animal models of Alzheimer’s disease as a tool for faster screening and testing of drug efficacy

   • Fabrizio Trinchese
   • Shumin Liu
   • Ottavio Arancio

   Assay And Animal Model Development Pages: 15 - 21

4. Novel approaches to models of Alzheimer’s disease pathology for drug screening and development

   • Laura Shaughnessy
   • Beth Chamblin
   • Ram Ramabhadran

   Assay And Animal Model Development Pages: 23 - 32

5. Validity of the Mindstreams™ computerized cognitive battery for mild cognitive impairment

   • Tzvi Dwolatzky
   • Victor Whitehead
   • Howard Chertkow

   Early Detection Pages: 33 - 44

6. Quantitative MRI assessment of Alzheimer’s disease

   • Joseph A. Helpern
   • Jens Jensen
   • Maria F. Falangola

   Early Detection Pages: 45 - 48

7. Development and evaluation of iodinated tracers targeting amyloid plaques for SPECT imaging

   • Mei-Ping Kung
   • Zhi-Ping Zhuang
   • Hank F. Kung

   Early Detection Pages: 49 - 53

8. Development of a PET/SPECT agent for amyloid imaging in Alzheimer’s disease

   • Yanming Wang
   • William E. Klunk
   • Chester A. Mathis

   Early Detection Pages: 55 - 62

9. Mapreg

   • Etienne-Emile Baulieu
   • Paul Robel
   • Sebastien David

   Neuroprotection Pages: 63 - 65

10. NAP mechanisms of neuroprotection

    • Illana Gozes
    • Ruth A. Steingart
    • Avron D. Spier

    Neuroprotection Pages: 67 - 72

11. Progress toward identification of protease activity involved in proteolysis of apolipoprotein E in human brain

    • Marcos A. Marques
    • Phillip A. Owens
    • Keith A. Crutcher

    Neuroprotection Pages: 73 - 80

12. Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors

    • Lei Zeng
    • Ken Chen
    • Ming-Ming Zhou

    Neuroprotection Pages: 81 - 84

13. Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys

    • Jerry J. Buccafusco
    • Alvin V. Terry

    Cognitive Enhancers Pages: 85 - 91

14. Role of acyl-coenzyme A

    • Luigi Puglielli
    • Blake C. Ellis
    • Dora M. Kovacs

    Lipid-Lowering Therapies Pages: 93 - 96

15. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer’s-like amyloid β in rabbit brain

    • D. Larry Sparks

    Lipid-Lowering Therapies Pages: 97 - 104

16. EFRH-phage immunization of Alzheimer’s disease animal model improves behavioral performance in morris water maze trials

    • Vered Lavie
    • Maria Becker
    • Beka Solomon

    Immunotherapy Pages: 105 - 113

17. Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation

    • Jeffrey M. Craft
    • Linda J. Van Eldik
    • D. Martin Watterson

    Neuroinflammation Pages: 115 - 122

18. Down-regulation of amyloid precursor protein by peptide nucleic acid in vivo

    • Mona Boules
    • Katrina Williams
    • Elliott Richelson

    Anti-Amyloid Pages: 123 - 128

19. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein

    • Lee Jae Morse
    • Sandra M. Payton
    • Jack T. Rogers

    Anti-Amyloid Pages: 129 - 136

20. Amyloid precursor protein compartmentalization restricts β-amyloid production

    • Swetal Gandhi
    • Lorenzo M. Refolo
    • Kumar Sambamurti

    Anti-Amyloid Pages: 137 - 143

21. Drug discovery

    • Jonathan D. Smith
    • Enakshi Chakrabarti
    • Justine A. Levin-Allerhand

    Anti-Amyloid Pages: 145 - 147

22. Transforming growth factor-β signaling pathway as a therapeutic target in neurodegeneration

    • Tony Wyss-Coray

    Anti-Amyloid Pages: 149 - 153

23. β-synuclein-derived peptides with neuroprotective activity

    • Manfred Windisch
    • Birgit Hutter-Paier
    • Robert Wronski

    Anti-Amyloid Pages: 155 - 165

24. Novel glycosaminoglycan precursors as antiamyloid agents

    • Robert Kisilevsky
    • Walter A. Szarek
    • Sandra Marone

    Anti-Amyloid Pages: 167 - 172