1. Guest editor’s introduction

   • Sangram S. Sisodia
   • Rudolph E. Tanzi

   EditorialNotes Pages: 99 - 99

2. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease

   • John C. Morris
   • Joseph L. Price

   OriginalPaper Pages: 101 - 118

3. Biological markers and the treatment of Alzheimer’s Disease

   • Douglas Galasko

   OriginalPaper Pages: 119 - 125

4. Dancing in the dark?

   • Lars Bertram
   • Rudolph E. Tanzi

   OriginalPaper Pages: 127 - 136

5. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer’s disease

   • Charles Glabe

   OriginalPaper Pages: 137 - 145

6. Role of apoE/Aβ interactions in the pathogenesis of Alzheimer’s disease and cerebral amyloid angiopathy

   • David M. Holtzman

   OriginalPaper Pages: 147 - 155

7. The β-secretase, BACE

   • Robert Vassar

   OriginalPaper Pages: 157 - 170

8. Implication of APP secretases in notch signaling

   • Dieter Hartmann
   • Jos Tournoy
   • Bart De Strooper

   OriginalPaper Pages: 171 - 181

9. Metabolism of Presenilins

   • Gopal Thinakaran

   OriginalPaper Pages: 183 - 192

10. Nuclear signaling

    • Harald Steiner
    • Christian Haass

    OriginalPaper Pages: 193 - 198

11. γ-Secretase inhibitors as molecular probes of presenilin function

    • Michael S. Wolfe

    OriginalPaper Pages: 199 - 204

12. Dysregulation of cellular calcium homeostasis in Alzheimer’s disease

    • Mark P. Mattson
    • Sic L. Chan

    OriginalPaper Pages: 205 - 224

13. Lewy body pathology in Alzheimer’s disease

    • Paul T. Kotzbauer
    • John Q. Trojanowski
    • Virginia M.-Y. Lee

    OriginalPaper Pages: 225 - 232

14. Genetically engineered models relevant to neurodegenerative disorders

    • Philip C. Wong
    • Huaibin Cai
    • Donald L. Price

    OriginalPaper Pages: 233 - 257

15. Potential treatment opportunities for Alzheimer’s disease through inhibition of secretases and Aβ immunization

    • Dale Schenk
    • Dora Games
    • Peter Seubert

    OriginalPaper Pages: 259 - 267

16. Editor’s note

    • Illana Gozes

    EditorialNotes Pages: 269 - 270