1. Symposium on novel therapeutic opportunities for neurodegenerative disease

   • Edgar F. da Cruz e Silva
   • Tiago Fleming Outeiro
   • Odete A. B. da Cruz e Silva

   Editorial Pages: 1 - 2

2. Current concepts and controversies in prion immunopathology

   • Mathias Heikenwalder
   • Marco Prinz
   • Adriano Aguzzi

   Review Article Pages: 3 - 11

3. Amyloid formation of a yeast prion determinant

   • Thomas Scheibel

   Review Article Pages: 13 - 22

4. Interactions among α-synuclein, dopamine, and biomembranes

   • Jean-Christophe Rochet
   • Tiago Fleming Outeiro
   • Peter T. Lansbury

   Review Article Pages: 23 - 33

5. Familial amyloidotic polyneuropathy

   • Maria João Saraiva
   • Mónica Mendes Sousa
   • Rui Fernandes

   Review Article Pages: 35 - 40

6. CFTR and chaperones

   • Margarida D. Amaral

   Review Article Pages: 41 - 48

7. Molecular genetics approaches in yeast to study amyloid diseases

   • Tiago Fleming Outeiro
   • Paul J. Muchowski

   Review Article Pages: 49 - 59

8. Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans

   • J. Alex Parker
   • Sébastien Holbert
   • Christian Néri

   Review Article Pages: 61 - 67

9. Role of heat shock proteins during polyglutamine neurodegeneration

   • Andreas Wyttenbach

   Review Article Pages: 69 - 95

10. Cell degeneration induced by amyloid-β peptides

    • Cláudia Pereira
    • Elisabete Ferreiro
    • Catarina Resende de Oliveira

    Review Article Pages: 97 - 104

11. Bace 1

    • Robert Vassar

    Review Article Pages: 105 - 113

12. Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer’s disease

    • Piotr Lewczuk
    • Hermann Esselmann
    • Jens Wiltfang

    Original Article Pages: 115 - 122

13. Signal transduction therapeutics

    • Odete A. B. da Cruz e Silva
    • Margarida Fardilha
    • Edgar F. Da Cruz e Silva

    Review Article Pages: 123 - 142

14. Mild cognitive impairment

    • Alexandre de Mendonça
    • Manuela Guerreiro
    • Carlos Garcia

    Review Article Pages: 143 - 147