1. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer’s disease

   • Kumar Sambamurti
   • Nigel H. Greig
   • Debomoy K. Lahiri

   Review Pages: 1 - 31

2. Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice

   • Pamela J. Skinner
   • Cynthia A. Vierra-Green
   • Harry T. Orr

   Original Research Pages: 33 - 42

3. Cell-free generation of the Notch1 intracellular domain (NICD) and APP-CTFγ

   • Takeshi Ikeuchi
   • Sangram S. Sisodia

   Original Research Pages: 43 - 54

4. Numb modifies neuronal vulnerability to amyloid β-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis

   • Sic L. Chan
   • Ward A. Pedersen
   • Mark P. Mattson

   Original Research Pages: 55 - 67

5. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3

   • Chengbiao Lu
   • Weiming Fu
   • Mark P. Mattson

   Original Research Pages: 69 - 79

6. The influence of the carboxyl terminus of the Alzheimer Aβ peptide on its conformation, aggregation, and neurotoxic properties

   • Brian Soreghan
   • Christian Pike
   • Charles G. Glabe

   Original Research Pages: 81 - 94