1. The Immunobiology of leukotriene inhibitors

   • Ronald A. Simon
   • Sally E. Wenzel

   Introduction Pages: 1 - 2

2. Regulation and metabolism of arachidonic acid

   • Michael C. Seeds
   • David A. Bass

   Basic Sciences Pages: 5 - 26

3. Biochemistry and physiology of the leukotrienes

   • Neil C. Barnes
   • Lewis J. Smith

   Basic Sciences Pages: 27 - 42

4. Regulation of expression of the 5-lipoxygenase pathway

   • Timothy D. Bigby

   Basic Sciences Pages: 43 - 58

5. Mutations in the human 5-lipoxygenase gene

   • Kwang-Ho In
   • Eric S. Silverman
   • Jeffrey M. Drazen

   Basic Sciences Pages: 59 - 69

6. The arachidonate 12/15 lipoxygenases

   • Douglas J. Conrad

   Basic Sciences Pages: 71 - 89

7. The enzymology and pharmacology of 5-lipoxygenase and 5-lipoxygenase activating protein

   • Randy L. Bell
   • Richard R. Harris

   Basic Sciences Pages: 91 - 109

8. Leukotrien A₄ hydrolase and the committed step in leukotriene B₄ biosynthesis

   • Jesper Z. Haeggström

   Basic Sciences Pages: 111 - 131

9. LTC₄ synthase

   • John F. Penrose

   Basic Sciences Pages: 133 - 152

10. The measurement of leukotrienes in human fluids

    • Jay Y. Westcott

    Basic Sciences Pages: 153 - 177

11. Leukotriene receptors

    • Sven-Erik Dahlén

    Basic Sciences Pages: 179 - 191

12. Pharmacology and safety of the leukotriene antagonists

    • Lewis J. Smith

    Clinical Sciences Pages: 195 - 212

13. Zileuton, a leukotriene synthesis inhibitor in the management of chronic asthma

    • Louise M. Dubé
    • Linda J. Swanson
    • Walid Awni

    Clinical Sciences Pages: 213 - 221

14. Antileukotrienes and laboratory models of asthma

    • Stephen C. Lazarus

    Clinical Sciences Pages: 223 - 233

15. Efficacy of anti-LT agents in the treatment of chronic asthma

    • Sheldon L. Spector

    Clinical Sciences Pages: 235 - 246

16. Pulmonary diseases other than asthma as potential targets for antileukotriene therapy

    • Marc Peters-Golden

    Clinical Sciences Pages: 247 - 260

17. Role of leukotrienes in antimicrobial host defense of the lung

    • Marc Peters-Golden
    • Michael Coffey

    Clinical Sciences Pages: 261 - 269

18. The role of leukotrienes and antileukotriene agents in the pathogenesis and treatment of allergic rhinitis

    • Ronald A. Simon

    Clinical Sciences Pages: 271 - 275