1. Foreword

   • Toby G. Rossman
   • Max Costa

   EditorialNotes Pages: i - ii

2. The effect of Ni(II) on DNA replication

   • Nelwyn T. Christie
   • Donna M. Tummolo

   Section 1 Metal-Nucleic Acid Interactions Pages: 3 - 12

3. Effect of nickel(II) on DNA-protein interactions

   • Timothy P. Coogan
   • Dorothy M. Latta
   • Max Costa

   Section 1 Metal-Nucleic Acid Interactions Pages: 13 - 21

4. Superoxide dismutase activity and novel reactions with hydrogen peroxide of histidine-containing nickel(II)-oligopeptide complexes and nickel(II)-induced structural changes in synthetic DNA

   • E. Nieboer
   • R. T. Tom
   • F. E. Rossetto

   Section 1 Metal-Nucleic Acid Interactions Pages: 23 - 33

5. Effect of chromium(III) on nucleolar RNA synthesis

   • Shoji Okada
   • Hideo Tsukada
   • Masakatsu Tezuka

   Section 1 Metal-Nucleic Acid Interactions Pages: 35 - 39

6. Models for enzyme-copper-nucleic acid interaction

   • Mallayan Palaniandavar

   Section 1 Metal-Nucleic Acid Interactions Pages: 41 - 48

7. Self-association of nucleotides

   • Helmut Sigel

   Section 1 Metal-Nucleic Acid Interactions Pages: 49 - 59

8. Effects of chromium(III) on DNA replication in vitro

   • Elizabeth T. Snow
   • Li-Sha Xu

   Section 1 Metal-Nucleic Acid Interactions Pages: 61 - 71

9. Cadmium binding proteins induced in exposed freshwater crayfishProcambarus clarkii

   • J. Del Ramo
   • A. Pastor
   • J. Diaz-Mayans

   Section 2 Metal Binding Proteins and Metal Resistance Pages: 75 - 80

10. Cadmium-induced metallothionein in earthworms (Lumbricus terrestris)

    • Arthur Furst
    • Quan Nguyen

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 81 - 85

11. The effect of lead on protein and DNA metabolism of normal and lead-adapted rat kidney cells in culture

    • B. Hitzfeld
    • F. Planas-Bohne
    • D. Taylor

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 87 - 95

12. Characterization of a nickel resistant mouse cell line

    • Richard J. Imbra
    • Xin-Wei Wang
    • Max Costa

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 97 - 103

13. Ferritin—A general metal detoxicant

    • J. G. Joshi
    • S. R. Sczekan
    • J. T. Fleming

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 105 - 110

14. Mammalian metallothionein

    • Jeremias H. R. Kägi
    • Peter Hunziker

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 111 - 118

15. Regulation of the isoforms of metallothionein

    • Curtis D. Klaassen
    • Lois D. Lehman-McKeeman

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 119 - 129

16. Modulation of metal toxicity by metallothionein

    • Gunnar F. Nordberg

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 131 - 135

17. Metal-protein interactions in transport, accumulation, and excretion of metals

    • Bibudhendra Sarkar

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 137 - 144

18. DNA sequence analysis of bacterial toxic heavy metal resistances

    • Simon Silver
    • Tapan K. Misra
    • Richard A. Laddaga

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 145 - 163

19. Metallothionein induction by nonsteroidal antiinflammatory drugs

    • Karl H. Summer
    • Dominik Klein
    • Josef Abel

    Section 2 Metal Binding Proteins and Metal Resistance Pages: 165 - 169

20. Dietary intake and bioavailability of trace elements

    • Mohamed Abdulla
    • Abdulla Behbehani
    • Hussein Dashti

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 173 - 178

21. Metabolic reduction of chromium, as related to its carcinogenic properties

    • Silvio De Flora
    • Domizio Serra
    • Patrizia Zanacchi

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 179 - 187

22. Interaction of lead with some essential elements in rat’s kidney in relation to age

    • M. Blanuša
    • M. Piasek
    • K. Kostial

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 189 - 193

23. On the mechanism of cellular cadmium uptake

    • E. C. Foulkes

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 195 - 200

24. Accumulation of methylmercury and inorganic mercury in the brain

    • Lars Friberg
    • N. Karle Mottet

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 201 - 206

25. The effects of cadmium on zinc absorption in isolated rat intestinal preparations

    • Daphne E. Coppen-Jaeger
    • Michael Wilhelm

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 207 - 212

26. Gut retention of metals in rats

    • K. Kostial
    • B. Kargačin
    • M. Landeka

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 213 - 218

27. Metabolism of methylmercury in rabbits and hamsters

    • Kierstin Petersson
    • Lennart Dock
    • Marie Vahter

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 219 - 226

28. Enhancement of the kidney Cd burden by SH-containing chelating agents

    • Waltraud Rau
    • Felicitas Planas-Bohne

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 227 - 231

29. Intracellular distribution and chemical forms of arsenic in rabbits exposed to arsenate

    • Marie Vahter
    • Erminio Marafante

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 233 - 239

30. Renal aluminum excretion

    • Michael Wilhelm
    • Doris Höhr
    • Friedrich K. Ohnesorge

    Section 3 Bioavailability, Metabolism, and Distribution Pages: 241 - 245

31. Interference of Manganese on neuroendocrinal system in exposed workers

    • L. Alessio
    • P. Apostoli
    • S. Lombardi

    Section 4 Mechanisms of Metal Toxicity Pages: 249 - 253

32. Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice

    • Helle Raun Andersen
    • Ole Andersen

    Section 4 Mechanisms of Metal Toxicity Pages: 255 - 261

33. Chromate effects on red cells membranes

    • Detmar Beyersmann
    • Barbara Buttner

    Section 4 Mechanisms of Metal Toxicity Pages: 263 - 270

34. The effect of K₂Cr₂O₇ on the growth and morphology ofEscherichia coli

    • Giorgio Brandi
    • Giuditta F. Schiavano
    • Orazio Cantoni

    Section 4 Mechanisms of Metal Toxicity Pages: 271 - 275

35. Role of metal ions in oxidant cell injury

    • Orazio Cantoni
    • Matteo Fumo
    • Flaminio Cattabeni

    Section 4 Mechanisms of Metal Toxicity Pages: 277 - 281

36. Induction of rat liver glutathione transferase isoenzyme 7-7 by lead nitrate

    • Lennart Dock

    Section 4 Mechanisms of Metal Toxicity Pages: 283 - 288

37. Alteration of steroid hormone sulfation andd-glucaric acid excretion in lead workers

    • A. Ferioli
    • P. Apostoli
    • L. Romeo

    Section 4 Mechanisms of Metal Toxicity Pages: 289 - 294

38. Complexation of labile metal ions and effect on toxicity

    • Arthur E. Martell

    Section 4 Mechanisms of Metal Toxicity Pages: 295 - 303

39. Fixation of the plasma membrane/cytoplasm complex: A mechanism of toxic interaction of tributyltin with the cell

    • Edward J. Massaro
    • Robert M. Zucker
    • Robert E. Easterling

    Section 4 Mechanisms of Metal Toxicity Pages: 305 - 312

40. Mechanism of cytotoxicity of methylmercury

    • Kyoko Miura
    • Nobumasa Imura

    Section 4 Mechanisms of Metal Toxicity Pages: 313 - 316

41. Subclinical response to cadmium in liver cells

    • Ludwig Müller
    • Neill H. Stacey

    Section 4 Mechanisms of Metal Toxicity Pages: 317 - 323

42. Lead-dithiocarbamate interaction

    • Agneta Oskarsson
    • Ewa Hellström-Lindahl

    Section 4 Mechanisms of Metal Toxicity Pages: 325 - 330

43. Multiple mechanisms of vanadate-induced cell killing

    • P. Richelmi
    • F. Berté
    • G. Bellomo

    Section 4 Mechanisms of Metal Toxicity Pages: 331 - 335

44. Effect of some nickel compounds on red blood cell characteristics

    • L. K. Tkeshelashvili
    • K. J. Tsakadze
    • O. V. Khulusauri

    Section 4 Mechanisms of Metal Toxicity Pages: 337 - 342

45. Cadmium, mercury, and lead effects on gill tissue of freshwater crayfishProcambarus clarkii (girard)

    • A. Torreblanca
    • J. Del Ramo
    • J. Diaz-Mayans

    Section 4 Mechanisms of Metal Toxicity Pages: 343 - 347

46. Decomposition of nucleoside hydroperoxide by metals and metalloproteins

    • Krystyna Frenkel
    • Soosan Tofigh

    Section 5 Genetic Effects Pages: 351 - 357

47. Comutagenicity and inhibition of DNA repair by metal ions in mammalian cells

    • Andrea Hartwig
    • Detmar Beyersmann

    Section 5 Genetic Effects Pages: 359 - 365

48. Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide

    • Shosuke Kawanishi
    • Sumiko Inoue
    • Koji Yamamoto

    Section 5 Genetic Effects Pages: 367 - 372

49. Mechanism of comutagenesis of sodium arsenite withn-methyl-n-nitrosourea

    • J. -H. Li
    • T. G. Rossman

    Section 5 Genetic Effects Pages: 373 - 381

50. On the mechanism of the comutagenic effect of Cu(II) with ultraviolet light

    • T. G. Rossman

    Section 5 Genetic Effects Pages: 383 - 388