1. Beginning a new Period celebrating the 60^th anniversary of the journal Scientia Sinica—(Science China)

   • Da-Cheng Wang

   Editorial 12 February 2010 Pages: 1 - 1

2. Life Science: Innovation and prosperity—commemorating the 60^th anniversary of the Chinese Academy of Sciences

   • JiaYang Li

   Article 12 February 2010 Pages: 2 - 12

3. A brief account on the study of the insulin crystal structure

   • Da-Cheng Wang
   • XiaoCheng Gu

   OriginalPaper 12 February 2010 Pages: 13 - 15

4. The first protein ever synthesized in vitro—a personal reminiscence of the total synthesis of crystalline insulin

   • YouShang Zhang

   Article 12 February 2010 Pages: 16 - 18

5. The background of the total synthesis of yeast alanine transfer RNA

   • GuoRong Qi

   Article 12 February 2010 Pages: 19 - 21

6. Proteomics in China: Ready for prime time

   • Xue Gao
   • XueLi Zhang
   • FuChu He

   Review 12 February 2010 Pages: 22 - 33

7. Regulation of Toll-like receptor signaling in the innate immunity

   • HuaZhang An
   • Cheng Qian
   • XueTao Cao

   Review 12 February 2010 Pages: 34 - 43

8. The next-generation sequencing technology: A technology review and future perspective

   • XiaoGuang Zhou
   • LuFeng Ren
   • Jun Yu

   Review 12 February 2010 Pages: 44 - 57

9. Intrinsically photosensitive retinal ganglion cells

   • Gary E. Pickard
   • Patricia J. Sollars

   Review 12 February 2010 Pages: 58 - 67

10. Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK

    • Li Yang
    • Min Liang
    • FanFan Hou

    Cover Article 12 February 2010 Pages: 68 - 77

11. Interrogating cell signalling network sensitively monitors cell fate transition during early differentiation of mouse embryonic stem cells

    • ZhiCao Yue
    • FengFeng Zhuang
    • Chih-ming Ho

    Research Paper 12 February 2010 Pages: 78 - 86

12. Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell line

    • Ran Meng
    • Jin Zhou
    • BaoFeng Yang

    Research Paper 12 February 2010 Pages: 87 - 93

13. A “GC-rich” method for mammalian gene expression: A dominant role of non-coding DNA GC content in regulation of mammalian gene expression

    • Qian Jia
    • HongTao Wu
    • Matthew (Mizhou) Hui

    Research Paper 12 February 2010 Pages: 94 - 100

14. microRNA-181b targets MLK2 in HL-60 cells

    • Hong Chen
    • Qun Chen
    • Yan Mi

    Research Paper 12 February 2010 Pages: 101 - 106

15. Sequencing, annotation and comparative analysis of nine BACs of giant panda (Ailuropoda melanoleuca)

    • Yang Zheng
    • Jing Cai
    • Jun Wang

    Research Paper 12 February 2010 Pages: 107 - 111

16. A meta-analysis of oxidative stress markers in schizophrenia

    • Ming Zhang
    • ZhongMing Zhao
    • ChunLing Wan

    Research Paper 12 February 2010 Pages: 112 - 124

17. Chloride channel-dependent copper acquisition of laccase in the basidiomycetous fungus Cryptococcus neoformans

    • ChangWei Zhu
    • Nan Jiang
    • XuDong Zhu

    Research Paper 12 February 2010 Pages: 125 - 130

18. Protocruzia, a highly ambiguous ciliate (Protozoa; Ciliophora): Very likely an ancestral form for Heterotrichea, Colpodea or Spirotrichea? With reevaluation of its evolutionary position based on multigene analyses

    • LiFang Li
    • Stoeck Thorsten
    • WeiBo Song

    Research Paper 12 February 2010 Pages: 131 - 138

19. The evolution of cooperation in asymmetric systems

    • RuiWu Wang
    • Lei Shi

    Research Paper 12 February 2010 Pages: 139 - 149

20. Science China In-Sight

    • ShiGang He

    In-Sight 12 February 2010 Pages: 150 - 150

21. It is not just AIV: From avian to swine-origin influenza virus

    • George F. Gao
    • YePing Sun

    In-Sight 12 February 2010 Pages: 151 - 153

22. iPS cells—Alternative pluripotent cells to embryo stem cells

    • XueTao Pei

    In-Sight 12 February 2010 Pages: 154 - 156