Volume 44, Issue 1

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February 2022

Special Issue: UW-NSC geroscience symposium and Special Issue: White matter lesions/cognitive decline

Issue Editors:

Matt Kaeberlein,
Alessandro Bitto,
Mitchell Lee,
Farzaneh Sorond,
Anna Csiszar,
Zoltan Ungvari

36 articles in this issue

Slowing down as we age: aging of the cardiac pacemaker’s neural control
Sabrina Choi
Matthias Baudot
Claudia M. Moreno
Original Article Open access 22 July 2021 Pages: 1 - 17
Part of 1 collection:

UW-NSC geroscience symposium
The understudied links of the retromer complex to age-related pathways
Kenneth A. Wilson
Original Article Open access 09 August 2021 Pages: 19 - 24
Part of 1 collection:

UW-NSC geroscience symposium
Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition
Shawn N. Whitehead
Askiel Bruno
Frank C. Barone
Original Article 04 October 2021 Pages: 25 - 37
Part of 1 collection:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair
Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49^th Annual Meeting of the American Aging Association
Michaela E. Murphy
Akilavalli Narasimhan
Yun Zhu
Editorial 29 October 2021 Pages: 39 - 52
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load
Jorge Quarleri
Veronica Galvan
M. Victoria Delpino
Editorial 18 December 2021 Pages: 53 - 56
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans
Veronica Galvan
Jorge Quarleri
Editorial 21 December 2021 Pages: 57 - 61
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
Editorial Focus: White matter-associated microglia (WAMs) represent an important link between aging, white matter disease and microglial activity
A. D. Roseborough
V. M. Jaremek
S. N. Whitehead
Editorial 12 August 2021 Pages: 63 - 65
Part of 1 collection:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair
Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice
Katarzyna M. Piekarz
Constantin Georgescu
Holly Van Remmen
Original Article 04 January 2022 Pages: 67 - 81
Part of 2 collections:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications

Understanding and overcoming the mechanisms driving age-related sarcopenia
Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury
David J. Robles
Ammar Dharani
Andrei Irimia
Original Article 26 October 2021 Pages: 83 - 102
Part of 1 collection:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
Ines Sanchez-Roman
Beatriz Ferrando
Tinna Stevnsner
Original Article 29 December 2021 Pages: 103 - 125
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?
Huawei Zhang
Richard J. Roman
Fan Fan
Commentary 28 August 2021 Pages: 127 - 130
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Higher-order resting state network association with the useful field of view task in older adults
Cheshire Hardcastle
Hanna K. Hausman
Adam J. Woods
Original Article 25 August 2021 Pages: 131 - 145
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study
Maud van Dinther
Miranda T. Schram
Julie Staals
Original Article Open access 23 November 2021 Pages: 147 - 157
Part of 2 collections:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair

Cell Biology of Vascular Aging
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study
Fabrizio Vecchio
Davide Quaranta
Paolo Maria Rossini
Original Article 31 December 2021 Pages: 159 - 172
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice
Anjanet Loon
Frank Zamudio
Maj-Linda B. Selenica
Original Article 19 August 2021 Pages: 173 - 194
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum
Alberto Fernández
Lucía Vaquero
ADNI–Alzheimer’s Disease Neuroimaging Initiative
Original Article Open access 30 September 2021 Pages: 195 - 209
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats
Andrei Gresita
Ruscu Mihai
Aurel Popa-Wagner
Original Article Open access 12 August 2021 Pages: 211 - 228
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet
Rita Cervera-Juanes
Priscila Darakjian
Henryk F. Urbanski
Original Article 13 October 2021 Pages: 229 - 252
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary
Nóra Balázs
Dániel Bereczki
Tibor Kovács
Original Article Open access 15 October 2021 Pages: 253 - 263
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis
Alexander M. Kulminski
Elena Loiko
Irina Culminskaya
Original Article 06 November 2021 Pages: 265 - 280
Seasonality of cognitive function in the general population: the Rotterdam Study
Sanne S. Mooldijk
Silvan Licher
M. Arfan Ikram
Original Article Open access 08 November 2021 Pages: 281 - 291
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats
Danut-Adrian Dumbrava
Roxana Surugiu
Aurel Popa-Wagner
Original Article Open access 10 November 2021 Pages: 293 - 310
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Early onset of aging phenotype in vascular repair by Mas receptor deficiency
Goutham Vasam
Shrinidh Joshi S
Yagna P. Jarajapu
Original Article 18 October 2021 Pages: 311 - 327
Part of 1 collection:

Cell Biology of Vascular Aging
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation
Gabrielle Rowe
Evan Tracy
Amanda J. LeBlanc
Original Article 04 October 2021 Pages: 329 - 348
Part of 1 collection:

Cell Biology of Vascular Aging
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17
Yanna Tian
Katie Anne Fopiano
Zsolt Bagi
Original Article 30 October 2021 Pages: 349 - 369
Part of 1 collection:

Cell Biology of Vascular Aging
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components
Partha K. Chandra
Sinisa Cikic
David W. Busija
Original Article Open access 28 October 2021 Pages: 371 - 388
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study
Lilla István
Cecilia Czakó
Illés Kovács
Original Article Open access 27 November 2021 Pages: 389 - 401
Part of 1 collection:

Cell Biology of Vascular Aging
Cardiovascular risk prediction in healthy older people
Johannes T. Neumann
Le T. P. Thao
John J. McNeil
Original Article Open access 11 November 2021 Pages: 403 - 413
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers
Nadine Bahour
Briana Cortez
Cristina Aguayo-Mazzucato
Original Article Open access 12 November 2021 Pages: 415 - 427
Divergent regulation of lncRNA expression by ischemia in adult and aging mice
Tamás Kaucsár
Beáta Róka
Péter Hamar
Original Article Open access 26 October 2021 Pages: 429 - 445
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy
Steve Horvath
Amin Haghani
Hippokratis Kiaris
Original Article Open access 26 October 2021 Pages: 447 - 461
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
Marco Raffaele
Kristina Kovacovicova
Manlio Vinciguerra
Original Article 24 November 2021 Pages: 463 - 483
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease
Mariam El Assar
Javier Angulo
Leocadio Rodríguez-Mañas
Original Article 28 December 2021 Pages: 485 - 501
Part of 1 collection:

Cell Biology of Vascular Aging
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes
Allancer D. C. Nunes
Moritz Weigl
Michal M. Masternak
Original Article 25 November 2021 Pages: 503 - 518
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants
Setor K. Kunutsor
Samuel Seidu
Jari A. Laukkanen
Original Article Open access 25 November 2021 Pages: 519 - 532
Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan
Chatrawee Duangjan
Sean P. Curran
Original Article Open access 12 October 2021 Pages: 533 - 545
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions

Volume 44, Issue 1

Slowing down as we age: aging of the cardiac pacemaker’s neural control

The understudied links of the retromer complex to age-related pathways

Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition

Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49^th Annual Meeting of the American Aging Association

Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load

Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans

Editorial Focus: White matter-associated microglia (WAMs) represent an important link between aging, white matter disease and microglial activity

Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice

Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury

Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians

Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?

Higher-order resting state network association with the useful field of view task in older adults

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study

Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice

Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum

Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats

Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet

Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis

Seasonality of cognitive function in the general population: the Rotterdam Study

Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats

Early onset of aging phenotype in vascular repair by Mas receptor deficiency

Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation

Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17

Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components

The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study

Cardiovascular risk prediction in healthy older people

Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers

Divergent regulation of lncRNA expression by ischemia in adult and aging mice

Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects

Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease

miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes

Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants

Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan

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