1. Platinum antitumour agents: A review of (bio)analysis

   • T. J. M. Hodes
   • W. J. M. Underberg
   • J. H. Beijnen

   Reviews Pages: 61 - 77

2. Clinical and pharmaceutical aspects in acute poisoning

   • R. G. Van Kesteren
   • D. R. A. Uges

   Reviews Pages: 78 - 82

3. Direct measurement of probenecid and its glucuronide conjugate by means of high pressure liquid chromatography in plasma and urine of humans

   • T. B. Vree
   • E. W. J. Beneken Kolmer

   Articles Pages: 83 - 87

4. Centralized preparation of hazardous drugs

   • P. Larrouturou
   • J. Huchet
   • M. -C. Taugourdeau

   Practice/Case Reports Pages: 88 - 92

5. Hydrocortisone anaphylaxis: A new case report

   • N. Corominas
   • J. M. Mañé
   • J. Ribas

   Practice/Case Reports Pages: 93 - 94

6. Abstracts of doctoral theses

   • C. -M. Lehr

   Abstract Pages: 95 - 96

7. Introduction

   • Harry Meinardi
   • Eppo Van der Kleijn

   EditorialNotes Pages: 97 - 97

8. Enzymes involved in the metabolism of valproate

   • J. Hulsman

   OriginalPaper Pages: 98 - 100

9. Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity

   • Heinz Nau
   • H. Siemes

   OriginalPaper Pages: 101 - 107

10. Influence of co-medication on the metabolism of valproate

    • Francesco Pisani

    OriginalPaper Pages: 108 - 113

11. Pharmacokinetics of valproate in pregnancy: Mother-foetus-newborn

    • Svein I. Johannessen

    OriginalPaper Pages: 114 - 117

12. Valproate hepatotoxicity syndrome: Hypotheses of pathogenesis

    • Jeffrey R. Stephens
    • René H. Levy

    OriginalPaper Pages: 118 - 121

13. Metabolism of valproate to hepatotoxic intermediates

    • Thomas A. Baillie

    OriginalPaper Pages: 122 - 125

14. Neural tube defects in association with epilepsy and its treatment

    • D. Chadwick

    OriginalPaper Pages: 126 - 126

15. Effects of valproate on xenobiotic biotransformation in rat liver

    • V. Rogiers
    • A. Callaerts
    • I. Phillips

    OriginalPaper Pages: 127 - 131

16. Strategies for identifying and developing new anticonvulsant drugs

    • Harvey J. Kupferberg

    OriginalPaper Pages: 132 - 138

17. Pharmacological, toxicological and neurochemical effects of Δ^2(E)-valproate in animals

    • Wolfgang Löscher

    OriginalPaper Pages: 139 - 143

18. Pharmacological, toxicological and neurochemical effects of Δ^2(E)-valproate in animals

    • Peter E. Keane

    OriginalPaper Pages: 144 - 145

19. Δ²-Valproate biotransformation using human liver microsomal fractions

    • Gérard Fabre
    • Christophe Briot
    • Jean -Paul Cano

    OriginalPaper Pages: 146 - 151

20. Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (Δ^2(E)-valproate) in healthy male volunteers

    • R. H. Düsing

    OriginalPaper Pages: 152 - 158

21. Studies on 2-n-propyl-2(E)-pentenoate (Δ^2(E)-valproate) in man

    • Lennart Gram

    OriginalPaper Pages: 159 - 160