The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts Priyamvada ChandraKim L. R. Brouwer OriginalPaper Pages: 719 - 735
Sp1-Dependent Regulation of the RTP801 Promoter and Its Application to Hypoxia-Inducible VEGF Plasmid for Ischemic Disease Minhyung LeeMalavosklish BikramSung Wan Kim OriginalPaper Pages: 736 - 741
Characterization of the Cellular Localization, Expression Level, and Function of SNP Variants of MRP2/ABCC2 Masakazu HirouchiHiroshi SuzukiYuichi Sugiyama OriginalPaper Pages: 742 - 748
Correction of Permeability with Pore Radius of Tight Junctions in Caco-2 Monolayers Improves the Prediction of the Dose Fraction of Hydrophilic Drugs Absorbed by Humans Ryoichi SaitohKiyohiko SuganoYoshinori Aso OriginalPaper Pages: 749 - 755
Transport Screening of Drug Cocktails Through an in Vitro Blood-Brain Barrier: Is It a Good Strategy for Increasing the Throughput of the Discovery Pipeline? V. BerezowskiC. LandryL. Fenart OriginalPaper Pages: 756 - 760
Characterization and Modulation of the Transferrin Receptor on Brain Capillary Endothelial Cells Corine C. VisserL. Heleen VoorwindenAlbertus G. de Boer OriginalPaper Pages: 761 - 769
Ocular Pharmacokinetic/Pharmacodynamic Modeling for Bunazosin After Instillation into Rabbits Koji SakanakaKouichi KawazuHitoshi Sasaki OriginalPaper Pages: 770 - 776
Analysis of Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics Data Sets Using VizStruct, a Novel Multidimensional Visualization Technique Kavitha BhasiLi ZhangMurali Ramanathan OriginalPaper Pages: 777 - 780
Urinary Excretion: Does It Accurately Reflect Relative Differences in Bioavailability/Systemic Exposure When Renal Clearance Is Nonlinear? Gary A. ThompsonRoger D. Toothaker OriginalPaper Pages: 781 - 784
Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes Kiyomi ItoJ. Brian Houston OriginalPaper Pages: 785 - 792
In Vitro and in Vivo Pharmacoscintigraphic Evaluation of Ibuprofen Hypromellose and Gelatin Capsules Ewart T. ColeRobert A. ScottIan R. Wilding OriginalPaper Pages: 793 - 798
Uptake of Melatonin into the Cerebrospinal Fluid After Nasal and Intravenous Delivery: Studies in Rats and Comparison with a Human Study Mascha P. van den BergPaul MerkusFrans W. H. M. Merkus OriginalPaper Pages: 799 - 802
Chitosan Nanoparticles as New Ocular Drug Delivery Systems: in Vitro Stability, in Vivo Fate, and Cellular Toxicity Angela M. de CamposYolanda DieboldMaria José Alonso OriginalPaper Pages: 803 - 810
Involvement of P-Glycoprotein in the Transport of Saquinavir and Indinavir in Rat Brain Microvessel Endothelial and Microglia Cell Lines Patrick T. RonaldsonGloria LeeReina Bendayan OriginalPaper Pages: 811 - 818
Predicting P-Glycoprotein Effects on Oral Absorption: Correlation of Transport in Caco-2 with Drug Pharmacokinetics in Wild-Type and mdr1a(-/-) Mice in Vivo Andrew CollettJolanta Tanianis-HughesGeoff Warhurst OriginalPaper Pages: 819 - 826
Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats Suna ChoiMiroslav BaudysSung Wan Kim OriginalPaper Pages: 827 - 831
Sustained Intravesical Drug Delivery Using Thermosensitive Hydrogel Pradeep TyagiZhenhua LiLeaf Huang OriginalPaper Pages: 832 - 837
A Method for Oral DNA Delivery with N-Acetylated Chitosan Eriko KaiTakahiro Ochiya OriginalPaper Pages: 838 - 843
Transdermal Iontophoresis of Rotigotine Across Human Stratum Corneum in Vitro: Influence of pH and NaCl Concentration Akhmad Kharis NugrohoGai Ling LiJoke A. Bouwstra OriginalPaper Pages: 844 - 850
On-Line Visualization of Dye Diffusion in Fresh Unfixed Human Skin Ylva Y. GramsLynne WhiteheadJoke A. Bouwstra OriginalPaper Pages: 851 - 859
Modeling and Monitoring of Polymorphic Transformations During the Drying Phase of Wet Granulation Tiffani D. DavisGarnet E. PeckStephen R. Byrn OriginalPaper Pages: 860 - 866
Effect of Aging on the Physical Properties of Amorphous Trehalose Rahul SuranaAbira PyneRaj Suryanarayanan OriginalPaper Pages: 867 - 874
A New Wet Conductivimetric Method to Estimate the Drug Percolation Threshold Álvaro Espina-MárquezIsidoro Caraballo OriginalPaper Pages: 875 - 881
Polymer Blends Used for the Coating of Multiparticulates: Comparison of Aqueous and Organic Coating Techniques Florence LecomteJuergen SiepmannRoland Bodmeier OriginalPaper Pages: 882 - 890
Oxaliplatin Degradation in the Presence of Chloride: Identification and Cytotoxicity of the Monochloro Monooxalato Complex Elin JerremalmMikael HedelandHans Ehrsson OriginalPaper Pages: 891 - 894