News from the National Institute of General Medical Sciences (NIGMS) Alisa Zapp Machalek News Pages: 1147 - 1148
An Interview with a Distinguished Pharmaceutical Scientist: Sung Wan Kim To whom correspondence should be addressed at Biomedical Polymers Research Building, Room 205, University of Utah, Salt Lake City, Utah 84112. Legacy Pages: 1149 - 1152
Fluorescence Recovery After Photobleaching: A Versatile Tool for Mobility and Interaction Measurements in Pharmaceutical Research Tom K. L. MeyvisStefaan C. De SmedtJoseph Demeester ReviewPaper Pages: 1153 - 1162
Design of Potent Phosphorothioate Antisense Oligonucleotides Directed to Human Interleukin 10 Gene Product and Their Evaluation of Antisense Activity in U937 Cells Hidetoshi ArimaMamiko TakahashiSeishi Tsuchiya OriginalPaper Pages: 1163 - 1171
Synthesis and In Vitro Evaluation of Aminoacyloxyalkyl Esters of 2-(6-methoxy-2-naphthyl)propionic Acid as Novel Naproxen Prodrugs for Dermal Drug Delivery Jarkko RautioTapio NevalainenTomi Järvinen OriginalPaper Pages: 1172 - 1178
Synthesis of a Lipophilic Prodrug of 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) and Its Incorporation into a Hepatocyte-Specific Lipidic Carrier Remco L. A. de VruehErik T. RumpMartin K. Bijsterbosch OriginalPaper Pages: 1179 - 1185
Solid-State Characteristics of Amorphous Sodium Indomethacin Relative to Its Free Acid Ping TongGeorge Zografi OriginalPaper Pages: 1186 - 1192
Compaction Properties of Composite Particles Consisting of Lactose with Sodium Alginate Prepared by Spray-Drying Hirofumi TakeuchiTakehiko YasujiYoshiaki Kawashima OriginalPaper Pages: 1193 - 1198
Comparison of CYP2D6 Content and Metoprolol Oxidation Between Microsomes Isolated from Human Livers and Small Intestines Soraya MadaniMary F. PaineDanny D. Shen OriginalPaper Pages: 1199 - 1205
Role of P-Glycoprotein on the CNS Disposition of Amprenavir (141W94), an HIV Protease Inhibitor Joseph W. PolliJeanne L. JarrettJoseph L. Woolley OriginalPaper Pages: 1206 - 1212
P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice Koichi YokogawaMegumi TakahashiAkira Tsuji OriginalPaper Pages: 1213 - 1218
Pharmacokinetics of Methotrexate in the Extracellular Fluid of Brain C6-Glioma After Intravenous Infusion in Rats Sylvain DukicTony HeurtauxRichard Vistelle OriginalPaper Pages: 1219 - 1225
Evaluation of the Pharmacokinetic Features and Tissue Distribution of the Potent Nonnucleoside Inhibitor of HIV-1 Reverse Transcriptase, N-[2-(2-fluorophenethyl)]-N′-[2-(5-bromopyridyl)]-thiourea (HI-240) with an Analytical HPLC Method Chun-Lin ChenFatih M. Uckun OriginalPaper Pages: 1226 - 1232
Impact of Regional Intestinal pH Modulation on Absorption of Peptide Drugs: Oral Absorption Studies of Salmon Calcitonin in Beagle Dogs Yong-Hee LeeBarbara A. PerryPatrick J. Sinko OriginalPaper Pages: 1233 - 1239
Gastropods as an Evaluation Tool for Screening the Irritating Potency of Absorption Enhancers and Drugs Els AdriaensJean Paul Remon OriginalPaper Pages: 1240 - 1244
Membrane-Interaction QSAR Analysis: Application to the Estimation of Eye Irritation by Organic Compounds Amit S. KulkarniA. J. Hopfinger OriginalPaper Pages: 1245 - 1253
Stool Water Content and Colonic Drug Absorption: Contrasting Effects of Lactulose and Codeine John M. HebdenPeter J. GilchristRobin C. Spiller OriginalPaper Pages: 1254 - 1259
Likelihood-Based Diagnostics for Influential Individuals in Non-Linear Mixed Effects Model Selection Sima SadrayE. Niclas JonssonMats O. Karlsson OriginalPaper Pages: 1260 - 1265
Transcellular and Lipophilic Complex-Enhanced Intestinal Absorption of Human Growth Hormone Sy-Juen WuJoseph R. Robinson OriginalPaper Pages: 1266 - 1272
A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity Dagmar FischerThorsten BieberThomas Kissel OriginalPaper Pages: 1273 - 1279
Organic Cation Transport in Rabbit Alveolar Epithelial Cell Monolayers Jie ShenKatharina J. ElbertVincent H. L. Lee OriginalPaper Pages: 1280 - 1287
Chemical Uptake Into Human Stratum Corneum In Vivo from Volatile and Non-Volatile Solvents Audra L. StinchcombFabrice PirotRichard H. Guy OriginalPaper Pages: 1288 - 1293
Why Does PEG 400 Co-Encapsulation Improve NGF Stability and Release from PLGA Biodegradable Microspheres? Jean-Manuel PéanFranck BouryJean-Pierre Benoit OriginalPaper Pages: 1294 - 1299
Controlled DNA Delivery Systems Dan LuoKim Woodrow-MumfordW. Mark Saltzman OriginalPaper Pages: 1300 - 1308
Pharmacokinetics and Tissue Disposition in Monkeys of an Antisense Oligonucleotide Inhibitor of Ha-Ras Encapsulated in Stealth Liposomes Rosie Z. YuRichard S. GearyArthur A. Levin OriginalPaper Pages: 1309 - 1315
Determination of Air Content in Protein Microspheres Svein KvåleKnut R. DyrstadOdd A. Asbjørnsen BriefCommunication Pages: 1316 - 1319