News from the National Institute of General Medical Sciences (NIGMS) Rochelle M. Long News Pages: 1149 - 1151
The Use of Modulated Temperature DSC for the Study of Pharmaceutical Systems: Potential Uses and Limitations Duncan Q. M. CraigPaul G. Royall Commentary Pages: 1152 - 1153
5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter Hyo-kyung HanRemco L. A. de VruehGordon L. Amidon1 Legacy Pages: 1154 - 1159
Characterization of the Regional Intestinal Kinetics of Drug Efflux in Rat and Human Intestine and in Caco-2 Cells Vijaya D. MakheyAilan GuoPatrick J. Sinko OriginalPaper Pages: 1160 - 1167
Carrier Mechanisms Involved in the Transepithelial Transport of bis(POM)-PMEA and Its Metabolites Across Caco-2 Monolayers P. AnnaertJ. Van GelderP. Augustijns OriginalPaper Pages: 1168 - 1173
A Comparison of the Bioconversion Rates and the Caco-2 Cell Permeation Characteristics of Coumarin-Based Cyclic Prodrugs and Methylester-Based Linear Prodrugs of RGD Peptidomimetics Gian P. CamenischWei WangRonald T. Borchardt OriginalPaper Pages: 1174 - 1181
Transbuccal Delivery of Acyclovir: I. In Vitro Determination of Routes of Buccal Transport Amir H. ShojaeiBret BernerXiaoling Li OriginalPaper Pages: 1182 - 1188
In Vivo Properties of an In Situ Forming Gel for Parenteral Delivery of Macromolecular Drugs Rajashree JoshiVikram AroraPatrick L. Iversen OriginalPaper Pages: 1189 - 1195
Guar Gum-Based Sustained Release Diltiazem Syed A. AltafKaren YuDavid R. Friend OriginalPaper Pages: 1196 - 1201
Phase Behavior of Binary and Ternary Amorphous Mixtures Containing Indomethacin, Citric Acid, and PVP Qun LuGeorge Zografi OriginalPaper Pages: 1202 - 1206
Particle Size Dependent Molecular Rearrangements During the Dehydration of Trehalose Dihydrate-In Situ FT-Raman Spectroscopy Lynne S. TaylorAdrian C. WilliamsPeter York OriginalPaper Pages: 1207 - 1214
Stabilization of Lactate Dehydrogenase Following Freeze-Thawing and Vacuum-Drying in the Presence of Trehalose and Borate Danforth P. MillerRebeccah E. AndersonJuan J. de Pablo OriginalPaper Pages: 1215 - 1221
Fractal Analysis of Pharmaceutical Particles by Atomic Force Microscopy Tonglei LiKinam Park OriginalPaper Pages: 1222 - 1232
Process Variable Implications for Residual Solvent Removal and Polymer Morphology in the Formation of Gentamycin-Loaded Poly (L-lactide) Microparticles Rick F. FalkTheodore W. Randolph OriginalPaper Pages: 1233 - 1237
Rate Control in Transdermal β-Estradiol Reservoir Membrane Systems: The Role of Membrane and Adhesive Layer Ralf AltenburgerUwe D. RohrThomas Kissel OriginalPaper Pages: 1238 - 1243
Tubular Localization and Tissue Distribution of Peptide Transporters in Rat Kidney David E. SmithAnna PavlovaJürgen B. Schnermann OriginalPaper Pages: 1244 - 1249
Enantioselective Tissue Distribution of the Basic Drugs Disopyramide, Flecainide and Verapamil in Rats: Role of Plasma Protein and Tissue Phosphatidylserine Binding Kazuhiko HanadaSatoko AkimotoHiroyasu Ogata OriginalPaper Pages: 1250 - 1256
Continuous Blood Withdrawal as a Rapid Screening Method for Determining Clearance and Oral Bioavailability in Rats W. Griffith HumphreysMary T. ObermeierRichard A. Morrison OriginalPaper Pages: 1257 - 1261
Investigation of Absorption Kinetics by the Phase Plane Method Aristides DokoumetzidisPanos Macheras OriginalPaper Pages: 1262 - 1269
Potential of Immobilized Artificial Membranes for Predicting Drug Penetration Across the Blood−Brain Barrier Andreas ReichelDavid J. Begley OriginalPaper Pages: 1270 - 1274
Evaluation of Cytotoxicity of Various Ophthalmic Drugs, Eye Drop Excipients and Cyclodextrins in an Immortalized Human Corneal Epithelial Cell Line Paula Saarinen-SavolainenTomi JärvinenArto Urtti OriginalPaper Pages: 1275 - 1280
Effect of Pancreatico-Biliary Secretions and GI Transit Time on the Absorption and Pharmacokinetic Profile of Ranitidine in Humans Kellie S. ReynoldsMin H. SongKim L. R. Brouwer OriginalPaper Pages: 1281 - 1285
Single-dose Pharmacokinetics of Rifapentine in Elderly Men Anther C. F. KeungMark G. EllerScott J. Weir OriginalPaper Pages: 1286 - 1291
Metrics Comparing Simulated Early Concentration Profiles for the Determination of Bioequivalence Laszlo EndrenyiFerenc CsizmadiaMei-Ling Chen OriginalPaper Pages: 1292 - 1299
Biexponential Decomposition of a Neuraminidase Inhibitor Prodrug (GS-4104) in Aqueous Solution Reza OliyaiLung-Chi YuanWilliam A. Lee OriginalPaper Pages: 1300 - 1304
Adsorptive-Mediated Transcytosis of a Synthetic Basic Peptide, 001-C8 in Caco-2 Cells Yoshimichi SaiMasahiro KajitaAkira Tsuji BriefCommunication Pages: 1305 - 1309
Considerations on the Potentiometric Log P Determination Stefanie D. KrämerJean-Claude GautierPhilippe Saudemon BriefCommunication Pages: 1310 - 1313
Assessment of Regional Differences in Intestinal Fluid Movement in the Rat Using a Modified In Situ Single Pass Perfusion Model Araz A. RaoofJackie ButlerJohn G. Devane BriefCommunication Pages: 1314 - 1316
