WHAT ARE “REINVENTION ACTIVITIES”? HOW IS THE NIH PARTICIPATING? WHAT CHANGES CAN BE EXPECTED AT THE NIH? HOW CAN I GET CURRENT INFORMATION? Rochelle M. Long Ph.D News Pages: 813 - 814
Biomaterials Science at a Crossroads: Are Current Product Liability Laws in the United States Hampering Innovation and the Development of Safer Medical Implants? Joachim Kohn Commentary Pages: 815 - 819
Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution Yoshinobu TakakuraMitsuru Hashida ReviewPaper Pages: 820 - 831
Population Pharmacokinetics of Terfenadine Richard L. LalondeDenis LessardJacques Gaudreault OriginalPaper Pages: 832 - 838
Evaluation of Pharmacokinetic Studies: Is It Useful to Take into Account Concentrations Below the Limit of Quantification? Henri HumbertMarie Danièle CabiacChristophe Gerbeau OriginalPaper Pages: 839 - 845
High Variability in Drug Pharmacokinetics Complicates Determination of Bioequivalence: Experience with Verapamil Yu Chung TsangRadu PopMichael Spino OriginalPaper Pages: 846 - 850
lontophoretic Delivery of a Telomeric Oligonucleotide Rhonda M. BrandPatrick L. Iversen OriginalPaper Pages: 851 - 854
Analysis of Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat Skin Kenji SugibayashiTeruaki HayashiYasunori Morimoto OriginalPaper Pages: 855 - 860
Targeted Delivery of Doxorubicin via Sterically Stabilized Immunoliposomes: Pharmacokinetics and Biodistribution in Tumor-bearing Mice Noam EmanuelEli KedarYechezkel Barenholz OriginalPaper Pages: 861 - 868
Erythrocytes as Carriers for Recombinant Human Erythropoietin Marina-Inmaculada GarínRosa-María LópezJosé Luque OriginalPaper Pages: 869 - 874
Formulation of Polyiodinated Triglyceride Analogues in a Chylomicron Remnant-Like Liver-Selective Delivery Vehicle Marc A. LonginoDouglas A. BakanRaymond E. Counsell OriginalPaper Pages: 875 - 879
Development and Pharmacokinetics of Galactosylated Poly-L-Glutamic Acid as a Biodegradable Carrier for Liver-Specific Drug Delivery Hideki HirabayashiMakiya NishikawaMitsuru Hashida OriginalPaper Pages: 880 - 884
Age-dependent Expression of P-Glycoprotein gp17O in Caco-2 Cell Monolayers Ken-ichi HosoyaKwang-Jin KimVincent H. L. Lee OriginalPaper Pages: 885 - 890
In Vivo Assessment of Intestinal, Hepatic, and Pulmonary First Pass Metabolism of Propofol in the Rat Araz A. RaoofPatrick R AugustijnsRoger K. Verbeeck OriginalPaper Pages: 891 - 895
Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes Hirofumi TakeuchiHiromitsu YamamotoYoshiaki Kawashima OriginalPaper Pages: 896 - 901
Contribution of Lysosomes to the Subcellular Distribution of Basic Drugs in the Rat Liver Junko IshizakiKoichi YokogawaFujio Ichimura OriginalPaper Pages: 902 - 906
Solubilization of Retinoids by Bile Salt/ Phospholipid Aggregates Ching-Yuan LiCheryl L. ZimmermanTimothy S. Wiedmann OriginalPaper Pages: 907 - 913
Permeation Behavior of Salbutamol Sulfate Through Hydrophilic and Hydrophobic Membranes Embedded by Thermo-responsive Cholesteryl Oleyl Carbonate Shan-Yang LinYih-Yih LinKo-Shao Chen OriginalPaper Pages: 914 - 919
The Effect of Hydrophobic Character of Drugs and Helix-coil Transition of κ-Carrageenan on the Polyelectrolyte-drug Interaction Ninus Caram-LelhamLars-Olof Sundelöf OriginalPaper Pages: 920 - 925
Determination of Molecular Mobility of Lyophilized Bovine Serum Albumin and γ-Globulin by Solid-State 1H NMR and Relation to Aggregation-Susceptibility Suraie YoshiokaYukio AsoShigeo Kojima OriginalPaper Pages: 926 - 930
Effects of Polyaminocarboxylate Metal Chelators on Iron-thiolate Induced Oxidation of Methionine- and Histidine-Containing Peptides Fang ZhaoJian YangChristian Schöneich OriginalPaper Pages: 931 - 938
Synthesis and Anti-proliferative Activity of 2-Hydroxy-l,2-dihydroacronycine Glycosides Sofia MitakuAlexios-Léandros SkaltsounisGhanem Atassi OriginalPaper Pages: 939 - 943
Investigations into the Relationship Between Drug Properties, Filling, and the Release of Drugs from Hard Gelatin Capsules Using Multivariate Statistical Analysis James HoganPei-Inn ShueJ. Michael Newton OriginalPaper Pages: 944 - 949
Effect of the Spermicide, Nonoxynol 9, on Vaginal Permeability in Normal and Ovariectomized Rabbits Füsun AcatürkJoseph R. Robinson Note Pages: 950 - 951
Primary Cell Culture of the Rabbit Choroid Plexus: An Experimental System to Investigate Membrane Transport Vikram K. RamanathanAndrew C. HuiKathleen M. Giacomini Note Pages: 952 - 956
The Effect of Iontophoresis on Skin Barrier Integrity: Non-invasive Evaluation by Impedance Spectroscopy and Transepidermal Water Loss Yogeshvar N. KaliaLourdes B. NonatoRichard H. Guy Note Pages: 957 - 960