The Role of Intramolecular Nucleophilic Catalysis and the Effects of Self-Association on the Deamidation of Human Insulin at Low pH Richard T. DarringtonBradley D. Anderson OriginalPaper Pages: 784 - 793
Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion Abraham RubinsteinBoaz Tirosh OriginalPaper Pages: 794 - 799
Predictions of in Vivo Plasma Concentrations from in Vitro Release Kinetics: Application to Doxepin Parenteral (I.M.) Suspensions in Lipophilic Vehicles in Dogs Christina GidoPeter LangguthErnst Mutschler OriginalPaper Pages: 800 - 808
Percutaneous Absorption of 2′,3′-Dideoxyinosine in Rats Elora MukherjiNancy J. MillenbaughJessie L.-S. Au OriginalPaper Pages: 809 - 815
Pharmacodynamic Models of Nitroglycerin-Induced Hemodynamic Tolerance in Experimental Heart Failure John Anthony BauerHo-Leung Fung OriginalPaper Pages: 816 - 823
Pharmacokinetics and Bioinversion of Ibuprofen Enantiomers in Humans Haiyung ChengJ. Douglas RogersElizabeth Depuy OriginalPaper Pages: 824 - 830
The Cutoff Time Point of the Partial Area Method for Assessment of Rate of Absorption in Bioequivalence Studies Panos MacherasMira SymillidesChristos Reppas OriginalPaper Pages: 831 - 834
Microdialysis: An Alternative for in Vitro and in Vivo Protein Binding Studies Anne Le QuellecSylvie DupinGeorges Houin OriginalPaper Pages: 835 - 838
Oral Bioavailability of the Antiretroviral Agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from Three Formulations of the Prodrug Bis(pivaloyloxymethyl)-PMEA in Fasted Male Cynomolgus Monkeys Kenneth C. CundyJames A. FishbackWilliam A. Lee OriginalPaper Pages: 839 - 843
HPLC Assay for FK 506 and Two Metabolites in Isolated Rat Hepatocytes and Rat Liver Microsomes Beatrice Y. T. PerottiThomayant PrueksaritanontLeslie Z. Benet OriginalPaper Pages: 844 - 847
Inhibition of Rat Splenocyte Proliferation with Methylprednisolone: In Vivo Effect of Liposomal Formulation Elena V. MishinaWilliam J. Jusko OriginalPaper Pages: 848 - 854
Comparison of Two Otitis Media Models for the Study of Middle Ear Antimicrobial Pharmacokinetics Daniel M. CanafaxHenry RusslieG. Scott Giebink OriginalPaper Pages: 855 - 859
Effect of Streptococcus pneumoniae and Influenza A Virus on Middle Ear Antimicrobial Pharmacokinetics in Experimental Otitis Media Gregg H. JossartDaniel M. CanafaxG. Scott Giebink OriginalPaper Pages: 860 - 864
Chemical Interactions Between Drugs Containing Reactive Amines with Hydrolyzable Insoluble Biopolymers in Aqueous Solutions Abraham J. DombLudmila TurovskyRaphael Nudelman OriginalPaper Pages: 865 - 868
Poly(Alkylcyanoacrylate) Nanocapsules: Physicochemical Characterization and Mechanism of Formation François ChouinardStéphane BuczkowskiVincent Lenaerts OriginalPaper Pages: 869 - 874
Structural Rheology of a Model Ointment Lorraine E. PenaBarbara L. LeeJames F. Stearns OriginalPaper Pages: 875 - 881
Mechanical Properties of Dry and Wet Cellulosic and Acrylic Films Prepared from Aqueous Colloidal Polymer Dispersions Used in the Coating of Solid Dosage Forms Roland BodmeierOrnlaksana Paeratakul OriginalPaper Pages: 882 - 888
Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes Amarnath SharmaRobert M. Straubinger OriginalPaper Pages: 889 - 896
Distribution of Brush-Border Membrane Peptidases Along the Rat Intestine Jane P. F. Bai OriginalPaper Pages: 897 - 900
Chemical Pathways of Peptide Degradation. VII. Solid State Chemical Instability of an Aspartyl Residue in a Model Hexapeptide Cecilia OliyaiJitendra P. PatelRonald T. Borchardt OriginalPaper Pages: 901 - 908
Improvement of the Pulmonary Absorption of (Asu1,7)-Eel Calcitonin by Various Protease Inhibitors in Rats Takahiro MoritaAkira YamamotoHitoshi Sezaki OriginalPaper Pages: 909 - 913
Geometric Approach for Zero-Order Release of Drugs Dispersed in an Inert Matrix Mohsen A. Bayomi Note Pages: 914 - 916
Interaction Between Ciprofloxacin and Metal Cations: Its Influence on Physicochemical Characteristics and Antibacterial Activity Ronald C. LiDavid E. NixJerome J. Schentag Note Pages: 917 - 920
Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and Nizatidine Steven A. WrightonBarbara J. Ring Note Pages: 921 - 924
A Regulatory and Industrial Perspective of the Use of Carbon-14 and Tritium Isotopes in Human ADME Studies Jeremy G. DainJerry M. CollinsWilliam T. Robinson Commentary Pages: 925 - 928