Relative Performance of Volume of Distribution Prediction Methods for Lipophilic Drugs with Uncertainty in LogP Value Ana L. CoutinhoRodrigo CristofolettiJames E. Polli Original Research Article Open access 08 May 2024
Observations on the Tritiated Water and TEWL Skin Integrity Tests: Relevance to In Vitro Permeation Testing (IVPT) Paul A. LehmanThomas J. Franz Original Research Article 08 May 2024
Accelerating Process Development and Product Formulation Mauricio FutranFernando MuzzioBikash Chatterjee Perspective 02 May 2024
Solubility vs Dissolution in Physiological Bicarbonate Buffer Felix ClaussenJozef Al-GousousPeter Langguth Original Research Article Open access 02 May 2024
Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms Nazli Pinar ArslanMesut TaskinOsman Nuri Keles Original Research Article Open access 29 April 2024
Evaluation of Various Approaches to Estimate Transplacental Clearance of Vancomycin for Predicting Fetal Concentrations using a Maternal–Fetal Physiologically Based Pharmacokinetic Model Yunan YanQiushi WangFeifan Xie Original Research Article 29 April 2024
Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer Nanami OkamotoMasaki HigashinoKiyohiko Sugano Original Research Article Open access 23 April 2024
Assessment of Tunable Resistive Pulse Sensing (TRPS) Technology for Particle Size Distribution in Vaccine Formulations – A Comparative Study with Dynamic Light Scattering Rahul MisraGinny FungMarina Kirkitadze Original Research Article 22 April 2024
Selective Delivery of Clindamycin Using a Combination of Bacterially Sensitive Microparticle and Separable Effervescent Microarray Patch on Bacteria Causing Diabetic Foot Infection Nurul FauziahNur Annisa SafirahAndi Dian Permana Original Research Article 18 April 2024
Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks Andżelika LorencAnna BaduraAdam Buciński Original Research Article Open access 17 April 2024
Machine Learning Exploration of the Relationship Between Drugs and the Blood–Brain Barrier: Guiding Molecular Modification Qi YangLili FanZhengcai Du Original Research Article 11 April 2024
A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution Karthik SalishChi SoChen Mao Original Research Article 08 April 2024
Development and Validation of Matrix of Chemistry, Manufacturing, and Control (MoCMC) System for Intramammary Drug Products (IMM) Nada A. HelalMarilyn N. MartinezMansoor A. Khan Original Research Article 01 April 2024
Antibiotic Development: Lessons from the Past and Future Opportunities Michael S. KinchZachary KraftTyler Schwartz Review Article 01 April 2024
Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control Vasanthakumar SekarDevarajan VedhachalamJean-Marie M. Geoffroy Original Research Article 01 April 2024
Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850) Toshifumi KimuraKen OkadaSusumu Shimoyama Original Research Article Open access 27 March 2024 Pages: 795 - 806
Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia Leiah J. BrigithaVeerle MondelaersInge M. van der Sluis Original Research Article 27 March 2024 Pages: 711 - 720
The Use of Global Sensitivity Analysis to Assess the Oral Absorption of Weakly Basic Compounds: A Case Example of Dipyridamole Siddharth S. KesharwaniGuillaume LouitFady Ibrahim Original Research Article 27 March 2024
Identification of Surfactant Impact on a Monoclonal Antibody Characterization via HPLC-Separation Based and Biophysical Methods Kaizhu GuoJing SongRico C. Gunawan Original Research Article 22 March 2024 Pages: 779 - 793
Predicting Drug-Drug Interactions Involving Rifampicin Using a Semi-mechanistic Hepatic Compartmental Model Jingxi LiXue LiBo Liu Original Research Article 22 March 2024 Pages: 699 - 709
Evaluation of Pharmacokinetic and Pharmacodynamic (PK/PD) of Novel Fluorenylmethoxycarbonyl- Phenylalanine Antimicrobial Agent Avinash Y. GahaneDevesh Pratap VermaAshwani K. Thakur Original Research Article 22 March 2024 Pages: 687 - 698
A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic Joseph R. CohenStephen R. BrychMarisa K. Joubert Original Research Article 22 March 2024 Pages: 651 - 672
Pharmacokinetic Profile of Brepocitinib with Topical Administration in Atopic Dermatitis and Psoriasis Populations: Strategy to Inform Clinical Trial Design in Adult and Pediatric Populations Farzaneh MalekiCheng ChangTimothy Nicholas Original Research Article Open access 22 March 2024 Pages: 623 - 636
Nonlinear Pharmacokinetics of Topical Flurbiprofen Gel in a Phase I Study Among Chinese Healthy Adults Wending XiaoZhihong ZhuZeneng Cheng Original Research Article 20 March 2024
Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies Mojgan SheikhiNasrin NemayandehMehrnoosh Shirangi Review Article 19 March 2024 Pages: 765 - 778
Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1 Naomi FukazawaTomohiro NishimuraMasatoshi Tomi Original Research Article 14 March 2024
Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs Kohei NakamuraAtsushi KambayashiSatomi Onoue Original Research Article Open access 12 March 2024 Pages: 673 - 685
When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers? Yunjiao WuKarel AllegaertSwantje Völler Original Research Article Open access 12 March 2024 Pages: 637 - 649
A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution Mika FutakiKazuya InamuraHiroaki Todo Original Research Article 05 March 2024 Pages: 819 - 831
Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease Da SunWenyu SunZheng-Rong Lu Original Research Article 05 March 2024 Pages: 807 - 817
Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects Xiangnan DangHan ShihDavid S. Collins Original Research Article 05 March 2024 Pages: 751 - 763
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms Chaozhuang ShenHongyi YangLing Wang Original Research Article 05 March 2024 Pages: 731 - 749
Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework Alessia RomagnoliFrancesco FerraraAndrea Zovi Perspectives 05 March 2024 Pages: 721 - 730
An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat Freddy ArceYue SchumanDivyakant Desai Original Research Article 21 February 2024 Pages: 595 - 607
Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng Ying YuLi Yun WangCheng Xiao Wang Original Research Article 21 February 2024 Pages: 513 - 529
Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999–2023) Xin WangJiangfan WuShenyin Zhu Original Research Article 21 February 2024 Pages: 609 - 622
Antibody-Drug Conjugate Overview: a State-of-the-art Manufacturing Process and Control Strategy Meng LiXueyu ZhaoLan Wang Review Article 17 February 2024 Pages: 419 - 440
Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation Hongyu YangFaxing ZhangJi Li Original Research Article 16 February 2024 Pages: 531 - 546
Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants Nitika NitikaB. KeerthiveenaAnurag S. Rathore Original Research Article 16 February 2024 Pages: 463 - 479
Medicinal Polypharmacology in the Clinic – Translating the Polypharmacolome into Therapeutic Benefit Muhammad RafehiMarius MöllerSven Marcel Stefan Perspectives Open access 16 February 2024 Pages: 411 - 417
In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules Daniel Sebastia-SaezGuoping LianTao Chen Original Research Article Open access 13 February 2024 Pages: 567 - 576
Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) Jeffry AdiwidjajaJessica SpiresKim L. R. Brouwer Original Research Article 13 February 2024 Pages: 441 - 462
Monte Carlo Optimization Method Based QSAR Modeling of Placental Barrier Permeability Predrag VukomanovićMilan StefanovićAleksandar M. Veselinović Original Research Article 09 February 2024 Pages: 493 - 500
Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule Qiannan YangTingting ZhangXin Jin Review Article 09 February 2024 Pages: 203 - 222
Structure Based Machine Learning Prediction of Retention Times for LC Method Development of Pharmaceuticals Jonathan FineAmanda K. Peterson MannPankaj Aggarwal Original Research Article 08 February 2024 Pages: 365 - 374
Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles Jihui LeeMalene A. NeustrupKoen van der Maaden Original Research Article Open access 08 February 2024 Pages: 305 - 319
Unraveling Pre-filled Syringe Needle Clogging: Exploring a Fresh Outlook Through Innovative Techniques Guangli HuDaniel BonannoVladimir Novak Original Research Article 07 February 2024 Pages: 547 - 556
Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm Huy M. DaoKhaled AboulFotouhRobert O. Williams III Original Research Article 07 February 2024 Pages: 501 - 512
Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice Victoria O. OyannaBaron J. BechtoldJohn D. Clarke Original Research Article 01 February 2024 Pages: 557 - 566
Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies Haoran MeiNa WangHongxun Hao Original Research Article 30 January 2024 Pages: 577 - 593